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Personal profile

Biography

After graduating from University College London in 1996 with a BEng in Biochemical Engineering, I carried out a PhD within the Advanced Centre for Biochemical Engineering at UCL. Entitled "An Engineering Evaluation of Expanded Bed Adsorption for the Recovery of a Typical Bioproduct", the study looked at hydrodynamic and kinetic influences on the performance of this novel unit operation.   After I completed my PhD I worked for two years in purification development at Metris Therapeutics, before returning to UCL to help establish the Innovative Manufacturing Research Centre for Bioprocessing. This multi-disciplinary research group was funded by the EPSRC to facilitate rapid development and scale-up of bioprocesses.   I moved to Heriot-Watt in April 2006, as part of the ScotChem initiative, and am currently pursuing research in scale-down and rapid process development in downstream processing operations, and have particular current interest in separation techniques for so-called "megamolecular" targets such as whole cells, plasmid DNA and viruses.

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  • 2 Similar Profiles
Adsorption Medicine & Life Sciences
Particle Size Medicine & Life Sciences
Purification Chemical Compounds
Alcohol Dehydrogenase Medicine & Life Sciences
Cell Separation Medicine & Life Sciences
Microalgae Medicine & Life Sciences
byproducts Agriculture & Biology
whisky Agriculture & Biology

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Research Output 1999 2018

Batch anaerobic digestion of deproteinated malt whisky pot ale using different source inocula

Barrena, R., Traub-Modinger, J., Rodriguez Gill, C., Goodwin, J. A. S., Harper, A., Willoughby, N., Sánchez, A. & Aspray, T. J., Jan 2018, In : Waste Management. 71, p. 675-682 8 p.

Research output: Contribution to journalArticle

Open Access
File
Anaerobic digestion
Methane
Distilleries
Proteins
Centrifugation

Impact of poloxamer 188 (Pluronic F-68) additive on cell mechanical properties, quantification by real-time deformability cytometry

Guzniczak, E., Jimenez, M., Irwin, M., Otto, O., Willoughby, N. & Bridle, H., 22 Aug 2018, In : Biomicrofluidics. 12, 4, 044118.

Research output: Contribution to journalArticle

Poloxamer
cytometry
Formability
mechanical properties
Mechanical properties

Challenges and advances in scale-up of label-free downstream processing for allogeneic cell therapies

Masri, F., Hoeve, M. A., De Sousa, P. A. & Willoughby, N. A., 4 Aug 2017, In : Cell and Gene Therapy Insights. 3, 6, p. 447-467 21 p.

Research output: Contribution to journalReview article

Open Access
File
Scalability
Labels
Centrifugation
Processing
Stem cells

Effect of organic carbon enrichment on the treatment efficiency of primary settled wastewater by Chlorella vulgaris

Evans, L., Hennige, S. J., Willoughby, N., Adeloye, A., Skroblin, M. & Gutierrez, T., Jun 2017, In : Algal Research. 24, Part A, p. 368–377

Research output: Contribution to journalArticle

Open Access
File
organic carbon
wastewater
inorganic compound
bioreactor
aeration

High-throughput assessment of mechanical properties of stem cell derived red blood cells, toward cellular downstream processing

Guzniczak, E., Mohammad Zadeh, M., Dempsey, F., Jimenez, M., Bock, H., Whyte, G., Willoughby, N. & Bridle, H., 31 Oct 2017, In : Scientific Reports. 7, 14457.

Research output: Contribution to journalArticle

Open Access
File
Stem Cells
Erythrocytes
Elastic Modulus
Cell Nucleus
Atomic Force Microscopy