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2018

Laser Ablation of Poly(lactic acid) Sheets for the Rapid Prototyping of Sustainable, Single-Use, Disposable Medical Microcomponents

Ongaro, A. E., Keraite, I., Liga, A., Conoscenti, G., Coles, S., Schulze, H., Bachmann, T. T., Parvez, K., Casiraghi, C., Howarth, N., La Carubba, V. & Kersaudy-Kerhoas, M., 2 Apr 2018, In : ACS Sustainable Chemistry and Engineering. 6, 4, p. 4899–4908 10 p.

Research output: Contribution to journalArticle

Open Access
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2017

Tryptophan and Non-Tryptophan Fluorescence of the Eye Lens Proteins Provides Diagnostics of Cataract at the Molecular Level

Gakamsky, A., Duncan, R. R., Howarth, N. M., Dhillon, B., Buttenschön, K. K., Daly, D. J. & Gakamsky, D., 10 Jan 2017, In : Scientific Reports. 7, 40375.

Research output: Contribution to journalArticle

Open Access
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55 Downloads (Pure)
2014

A Low-Cost Method for Measuring the Permeability of a Pharmaceutical Drug in a Diffusion Cell

Kitson, M., Sheppard, H. N., Morris, J. C., Howarth, N. M. & Kraft, A. M., 2014, In : Chemical Educator. 19, p. 310-313 4 p.

Research output: Contribution to journalArticle

File
142 Downloads (Pure)
2013

Development of a convenient route for the preparation of the N 2-Cbz-protected guaninyl synthon required for Boc-mediated PNA synthesis

Heuer-Jungemann, A., Howarth, N. M., Ja’afaru, S. C. & Rosair, G. M., 13 Nov 2013, In : Tetrahedron Letters. 54, 46, p. 6275-6278 4 p.

Research output: Contribution to journalArticle

2011

Synthesis of N-propynyl analogues of peptide nucleic acid (PNA) monomers and their use in the click reaction to prepare N-functionalized PNAs

Howarth, N. M. & Goujon (nee Ricci), J., 9 Dec 2011, In : Tetrahedron. 67, 49, p. 9588-9594 7 p.

Research output: Contribution to journalArticle

2008

Peptides derived from nucleoside β-amino acids form an unusual 8-helix

Threlfall, R., Davies, A., Howarth, N. M., Fisher, J. & Cosstick, R., 2008, In : Chemical Communications. 8, 5, p. 585-587 3 p.

Research output: Contribution to journalArticle

2007

Foldamers derived from nucleoside β-amino acids: PNA or DNA? Can we have both in one place?

Threlfall, R., Davies, A., Howarth, N. & Cosstick, R., Jun 2007, In : Nucleosides, Nucleotides and Nucleic Acids. 26, 6-7, p. 611-614 4 p.

Research output: Contribution to journalArticle

Investigation of novel lipid-functionalized PNA monomers as potential HIV-1 non-nucleoside reverse transcriptase and/or integrase inhibitors

Thomas, M. G., Maga, G., Mouscadet, J. F. & Howarth, N. M., Aug 2007, In : Nucleosides, Nucleotides and Nucleic Acids. 26, 8-9, p. 1063-1066 4 p.

Research output: Contribution to journalArticle

N2-benzyloxycarbonylguan-9-yl acetic acid derivatives as HIV-1 reverse transcriptase non-nucleoside inhibitors with decreased loss of potency against common drug-resistance mutations

Adebambo, K. F., Zanoli, S., Thomas, M. G., Cancio, R., Howarth, N. M. & Maga, G., 8 Oct 2007, In : ChemMedChem. 2, 10, p. 1405-1409 5 p.

Research output: Contribution to journalArticle

Potentiometric determination of octanol-water and liposome-water partition coefficients (log P) of ionizable organic compounds

Barzanti, C., Evans, R., Fouquet, J., Gouzin, L., Howarth, N. M., Kean, G., Levet, E., Wang, D., Wayemberg, E., Yeboah, A. A. & Kraft, A., 7 May 2007, In : Tetrahedron Letters. 48, 19, p. 3337-3341 5 p.

Research output: Contribution to journalArticle

2006

Investigation of 1,3-dipolar cycloaddition reactions of unsaturated nitrones in ionic liquids

Hornyák, M., Kele, Z., Kovács, L., Forgó, P. & Howarth, N., 1 Sep 2006, In : Nucleosides, Nucleotides and Nucleic Acids. 25, 8, p. 867-870 4 p.

Research output: Contribution to journalArticle

Single diastereomers of polyhydroxylated 9-Oxa-1-azabicyclo[4.2.1]nonanes from intramolecular 1,3-dipolar cycloaddition of ω-unsaturated nitrones

Pádár, P., Bokros, A., Paragi, G., Forgó, P., Kele, Z., Howarth, N. M. & Kovács, L., 27 Oct 2006, In : Journal of Organic Chemistry. 71, 22, p. 8669-8672 4 p.

Research output: Contribution to journalArticle

2005

An intramolecular 1,3-dipolar cycloaddition reaction towards the synthesis of chiral azetidine nucleoside analogues: The D-gluco case

Pádár, P., Forgó, P., Kele, Z., Howarth, N. M. & Kovács, L., 2005, In : Nucleosides, Nucleotides and Nucleic Acids. 24, 5-7, p. 743-745 3 p.

Research output: Contribution to journalArticle

Benzyl 2-amino-6-chloro-9H-purine-9-carboxylate

Adebambo, K. F., Howarth, N. M. & Rosair, G. M., Feb 2005, In : Acta Crystallographica Section E: Structure Reports Online. 61, 2, p. o486-o488

Research output: Contribution to journalArticle

Intramolecular 1,3-dipolar cycloaddition of unsaturated nitrones derived from methyl α-d-glucopyranoside

Pádár, P., Hornyák, M., Forgó, P., Kele, Z., Paragi, G., Howarth, N. M. & Kovács, L., 11 Jul 2005, In : Tetrahedron. 61, 28, p. 6816-6823 8 p.

Research output: Contribution to journalArticle

Lipophilic peptide nucleic acids containing a 1,3-diyne function: Synthesis, characterization and production of derived polydiacetylene liposomes

Howarth, N. M., Lindsell, W. E., Murray, E. & Preston, P. N., 12 Sep 2005, In : Tetrahedron. 61, 37, p. 8875-8887 13 p.

Research output: Contribution to journalArticle

2004

Experimental and ab initio computational studies of self-association: 2-Aminopyridine and 3-aminopyridine

Boyd, A. S. F., Frost, M. J. & Howarth, N. M., 21 Jan 2004, In : Journal of Molecular Structure. 688, 1-3, p. 149-158 10 p.

Research output: Contribution to journalArticle

2003

a-cycloPNA: l-aminocyclopentane-l-carboxylic acid derived peptide nucleic acid

Howarth, N. M., Walker, D. M. & Wakelin, L. P. G., 2003, In : Nucleosides, Nucleotides and Nucleic Acids. 22, p. 1351-1353 3 p.

Research output: Contribution to journalArticle

Conformationally restricted chiral peptide nucleic acids derived from azetidines

Kovács, L., Hornyák, M. & Howarth, N. M., 2003, In : Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, p. 1363-1365 3 p.

Research output: Contribution to journalArticle

Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid

Howarth, N. M., Lindsell, W. E., Murray, E. & Preston, P. N., 27 Oct 2003, In : Tetrahedron Letters. 44, 44, p. 8089-8092 4 p.

Research output: Contribution to journalArticle

Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10, 12-diynoic acid

Howarth, N. M., Lindsell, E., Murray, E. & Preston, P. N., 2003, In : Tetrahedron Letters. 44, p. 8089-8092 4 p.

Research output: Contribution to journalArticle

Synthesis of the four diastereoisomers of 3-thymine-1-(tbutoxycarbonyl)aminocyclopentane-1-carboxylic acid

Howarth, N. M., Wakelin, L. P. G. & Walker, D. M., 20 Jan 2003, In : Tetrahedron Letters. 44, 4, p. 695-698 4 p.

Research output: Contribution to journalArticle

Synthesis of the four diastereoisomers of 3-thymine-l-(tbutoxycarb onyl)aminocyclopentane-l-carboxylic acid

Howarth, N. M., Walker, D. M. & Wakelin, L. P. G., 2003, In : Tetrahedron Letters. 44, p. 695-698 4 p.

Research output: Contribution to journalArticle

Synthesis of thymine derivatives of 4-hydroxyvaline

Abraham, A. & Howarth, N. M., 2003, In : Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, p. 675-677 3 p.

Research output: Contribution to journalArticle

α-cycloPNA: 1-Aminocylopentane-1-carboxylic acid-derived peptide nucleic acid

Howarth, N. M., Wakelin, L. P. G. & Walker, D. M., 2003, In : Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, p. 1351-1353 3 p.

Research output: Contribution to journalArticle

2002

Estrone 3-sulfate mimics, inhibitors of estrone sulfatase activity: Homology model construction and docking studies

Howarth, N. M., Purohit, A., Robinson, J. J., Vicker, N., Reed, M. J. & Potter, B. V. L., 17 Dec 2002, In : Biochemistry. 41, 50, p. 14801-14814 14 p.

Research output: Contribution to journalArticle

Estrone 3-Sulfate Mimics. Inhibitors of Estrone Sulfatase Activity: Homology Model Construction and Docking Studies

Howarth, N. M., Purohit, A., Robinson, J. J., Vicker, N., Reed, M. J. & Potter, B. V. L., 2002, In : Biochemistry.

Research output: Contribution to journalArticle

1998

Manipulation of Substituents at Nitrogen in Tropanes, Homotropanes and Dehydro- Derivatives

Howarth, N. M., Malpass, J. R. & Smith, C. R., 1998, In : Tetrahedron. 54, p. 10899-10914 16 p.

Research output: Contribution to journalArticle

Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase

Woo, L. W. L., Howarth, N. M., Purohit, A., Hejaz, H. A. M., Reed, M. J. & Potter, B. V. L., 26 Mar 1998, In : Journal of Medicinal Chemistry. 41, 7, p. 1068-1083 16 p.

Research output: Contribution to journalArticle

Steroidal and Non-steroidal Sulfamates as Potent Inhibitors of Steroid Sulfatase

Woo, L. W. L., Howarth, N. M., Purohit, A., Hejaz, H. A. M., Reed, M. J. & Potter, B. V. L., 1998, In : Journal of Medicinal Chemistry. 41, p. 1068-1083 16 p.

Research output: Contribution to journalArticle

1997

Alpha-PNA: A Novel Peptide Nucleic Acid Analogue of DNA

Howarth, N. M. & Wakelin, L. P. G., 1997, In : J. Org. Chem.. 62, p. 5441-5450 10 p.

Research output: Contribution to journalArticle

Estrone Sulphonates as Inhibitors of Estrone Sulphatase

Howarth, N. M., Purohit, A., Reed, M. J. & Potter, B. V. L., 1997, In : Steroids. 62, p. 346-350 5 p.

Research output: Contribution to journalArticle

1996

DNA Threading Agents. Effect of Sidechain Bulk on DNA Binding and Cytotoxicity of 9-anilinoacridine-4-carboxamides

Searcey, M., Howarth, N. M., Madden, B. & Wakelin, L. P. G., 1996, In : Bioorganic and Medicinal Chemistry Letters. 6, p. 1831-1836 6 p.

Research output: Contribution to journalArticle

1995

Inactivation of Steroid Sulfatase by an Active Site-Directed Inhibitor, Estrone-3-O-Sulfamate

PUROHIT, A., Williams, G. J., HOWARTH, N. M., Potter, B. V. L. & REED, M. J., 12 Sep 1995, In : Biochemistry. 34, 36, p. 11508-11514 7 p.

Research output: Contribution to journalArticle

1994

Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potential

HOWARTH, N. M., Purohit, A., REED, M. J. & Potter, B. V. L., 21 Jan 1994, In : Journal of Medicinal Chemistry. 37, 2, p. 219-221 3 p.

Research output: Contribution to journalArticle

INHIBITION OF STEROID SULFATASE ACTIVITY BY STEROIDAL METHYLTHIOPHOSPHONATES - POTENTIAL THERAPEUTIC AGENTS IN BREAST-CANCER

PUROHIT, A., HOWARTH, N. M., POTTER, B. V. L. & REED, M. J., Apr 1994, In : Journal of Steroid Biochemistry and Molecular Biology. 48, 5-6, p. 523-527 5 p.

Research output: Contribution to journalArticle

1993

INHIBITION OF ESTRONE SULFATASE ACTIVITY BY ESTRONE-3-METHYLTHIOPHOSPHONATE - A POTENTIAL THERAPEUTIC AGENT IN BREAST-CANCER

DUNCAN, L., PUROHIT, A., HOWARTH, N. M., POTTER, B. V. L. & REED, M. J., 15 Jan 1993, In : Cancer Research. 53, 2, p. 298-303 6 p.

Research output: Contribution to journalArticle

PHOSPHONATES AND THIOPHOSPHONATES AS SULFATE SURROGATES - SYNTHESIS OF ESTRONE 3-METHYLTHIOPHOSPHONATE, A POTENT INHIBITOR OF ESTRONE SULFATASE

HOWARTH, N. M., COOPER, G., PUROHIT, A., DUNCAN, L., REED, M. J. & POTTER, B. V. L., Feb 1993, In : Bioorganic and Medicinal Chemistry Letters. 3, 2, p. 313-318 6 p.

Research output: Contribution to journalArticle

SYNTHETIC APPROACHES TO NORTROPANES AND NORTROP-6-ENES - INTRAMOLECULAR DISPLACEMENT BY NITROGEN IN 7-MEMBERED RINGS

NAYLOR, A., HOWARTH, N. & MALPASS, J. R., 8 Jan 1993, In : Tetrahedron. 49, 2, p. 451-468 18 p.

Research output: Contribution to journalArticle