19932018

Research output per year

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Research Output

2018

Laser Ablation of Poly(lactic acid) Sheets for the Rapid Prototyping of Sustainable, Single-Use, Disposable Medical Microcomponents

Ongaro, A. E., Keraite, I., Liga, A., Conoscenti, G., Coles, S., Schulze, H., Bachmann, T. T., Parvez, K., Casiraghi, C., Howarth, N., La Carubba, V. & Kersaudy-Kerhoas, M., 2 Apr 2018, In : ACS Sustainable Chemistry and Engineering. 6, 4, p. 4899–4908 10 p.

Research output: Contribution to journalArticle

Open Access
File
48 Downloads (Pure)

Rapid prototyping for micro-engineering and microfluidic applications: Recycled pmma, a sustainable substrate material

Ongaro, A. E., Howarth, N., La Carrubba, V. & Kersaudy-Kerhoas, M., 2018, Advances in Manufacturing Technology XXXII. Thorvald, P. & Case, K. (eds.). IOS Press, p. 107-112 6 p. (Advances in Transdisciplinary Engineering; vol. 8).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
File
22 Downloads (Pure)
2017

Tryptophan and Non-Tryptophan Fluorescence of the Eye Lens Proteins Provides Diagnostics of Cataract at the Molecular Level

Gakamsky, A., Duncan, R. R., Howarth, N. M., Dhillon, B., Buttenschön, K. K., Daly, D. J. & Gakamsky, D., 10 Jan 2017, In : Scientific Reports. 7, 40375.

Research output: Contribution to journalArticle

Open Access
File
55 Downloads (Pure)

Ultra-fast-prototyping of PMMA structures for micro-engineering applications: Choosing the right material

Ongaro, A. E., Conoscenti, G., Liga, A., Brucato, V., Desmulliez, M. P. Y., Howarth, N., La Carrubba, V. & Kersaudy-Kerhoas, M., 2017, Advances in Manufacturing Technology XXXI - Proceedings of the 15th International Conference on Manufacturing Research, ICMR 2017: Incorporating the 32nd National Conference on Manufacturing Research. Gao, J., El Souri, M. & Keates, S. (eds.). IOS Press, Vol. 6. p. 181-186 6 p. (Advances in Transdisciplinary Engineering).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2014

A Low-Cost Method for Measuring the Permeability of a Pharmaceutical Drug in a Diffusion Cell

Kitson, M., Sheppard, H. N., Morris, J. C., Howarth, N. M. & Kraft, A. M., 2014, In : Chemical Educator. 19, p. 310-313 4 p.

Research output: Contribution to journalArticle

File
142 Downloads (Pure)
2013

Development of a convenient route for the preparation of the N 2-Cbz-protected guaninyl synthon required for Boc-mediated PNA synthesis

Heuer-Jungemann, A., Howarth, N. M., Ja’afaru, S. C. & Rosair, G. M., 13 Nov 2013, In : Tetrahedron Letters. 54, 46, p. 6275-6278 4 p.

Research output: Contribution to journalArticle

2011

Synthesis of N-propynyl analogues of peptide nucleic acid (PNA) monomers and their use in the click reaction to prepare N-functionalized PNAs

Howarth, N. M. & Goujon (nee Ricci), J., 9 Dec 2011, In : Tetrahedron. 67, 49, p. 9588-9594 7 p.

Research output: Contribution to journalArticle

Transition Metal Ion Complexes of N-alkylguanines

Ferenc, G., Padar, P., Szolomajer, J., Howarth, N. M. & Kovacs, L., Aug 2011, In : Current Organic Chemistry. 15, 16, p. 2871-2892 22 p.

Research output: Contribution to journalLiterature review

2009

Development of a novel triazole-containing oligonucleotide analog as a potential antigene agent

Tazioli, L. A. & Howarth, N. M., 16 Aug 2009, p. -. 1 p.

Research output: Contribution to conferenceAbstract

Synthetic approaches to novel triazole-containing nucleic acid (TCNA) analogs

Tazioli, L. A. M. & Howarth, N. M., 16 Aug 2009, p. -. 1 p.

Research output: Contribution to conferenceAbstract

2008

ANYL 37-Development of potential novel colorimetric nucleic acid biosensors.

Goujon (nee Ricci), J. & Howarth, N. M., 17 Aug 2008, p. -. 1 p.

Research output: Contribution to conferenceAbstract

MEDI 416-Synthesis of peptide nucleic acid-functionalized polydiacetylene liposomes: Potential novel colorimetric nucleic acid biosensors

Goujon (nee Ricci), J. & Howarth, N. M., 17 Aug 2008, p. -. 1 p.

Research output: Contribution to conferenceAbstract

Peptides derived from nucleoside β-amino acids form an unusual 8-helix

Threlfall, R., Davies, A., Howarth, N. M., Fisher, J. & Cosstick, R., 2008, In : Chemical Communications. 8, 5, p. 585-587 3 p.

Research output: Contribution to journalArticle

2007

Foldamers derived from nucleoside β-amino acids: PNA or DNA? Can we have both in one place?

Threlfall, R., Davies, A., Howarth, N. & Cosstick, R., Jun 2007, In : Nucleosides, Nucleotides and Nucleic Acids. 26, 6-7, p. 611-614 4 p.

Research output: Contribution to journalArticle

Investigation of novel lipid-functionalized PNA monomers as potential HIV-1 non-nucleoside reverse transcriptase and/or integrase inhibitors

Thomas, M. G., Maga, G., Mouscadet, J. F. & Howarth, N. M., Aug 2007, In : Nucleosides, Nucleotides and Nucleic Acids. 26, 8-9, p. 1063-1066 4 p.

Research output: Contribution to journalArticle

N2-benzyloxycarbonylguan-9-yl acetic acid derivatives as HIV-1 reverse transcriptase non-nucleoside inhibitors with decreased loss of potency against common drug-resistance mutations

Adebambo, K. F., Zanoli, S., Thomas, M. G., Cancio, R., Howarth, N. M. & Maga, G., 8 Oct 2007, In : ChemMedChem. 2, 10, p. 1405-1409 5 p.

Research output: Contribution to journalArticle

Potentiometric determination of octanol-water and liposome-water partition coefficients (log P) of ionizable organic compounds

Barzanti, C., Evans, R., Fouquet, J., Gouzin, L., Howarth, N. M., Kean, G., Levet, E., Wang, D., Wayemberg, E., Yeboah, A. A. & Kraft, A., 7 May 2007, In : Tetrahedron Letters. 48, 19, p. 3337-3341 5 p.

Research output: Contribution to journalArticle

Predicting drug absorption from permeability measurements across a lipid-coated membrane using a diffusion cell and a UV spectrophotometer

Kraft, A., Howarth, N. M., Sheppard, H. N., Perston, H. & Fouquet, J., 25 Mar 2007, p. 661-661. 1 p.

Research output: Contribution to conferenceAbstract

2006

ANYL 60-Liposome-water distribution coefficients of pharmaceutical drugs: Using second derivative absorption spectra and potentiometric titrations: A comparison between two methods

Kraft, A., Howarth, N. M., Wang, D., Leger, A-S., Evans, R., Gouzin, L., Yeboah, A. A. & Fouquet, J., 10 Sep 2006, In : Abstracts of Papers: American Chemical Society Meetings. 232, p. - 1 p.

Research output: Contribution to journalMeeting abstract

Investigation of 1,3-dipolar cycloaddition reactions of unsaturated nitrones in ionic liquids

Hornyák, M., Kele, Z., Kovács, L., Forgó, P. & Howarth, N., 1 Sep 2006, In : Nucleosides, Nucleotides and Nucleic Acids. 25, 8, p. 867-870 4 p.

Research output: Contribution to journalArticle

Recent advances in the field of peptide nucleic acids

Howarth, N. M., Jul 2006, In : Letters in Organic Chemistry. 3, 7, p. 495-503 9 p.

Research output: Contribution to journalLiterature review

Single diastereomers of polyhydroxylated 9-Oxa-1-azabicyclo[4.2.1]nonanes from intramolecular 1,3-dipolar cycloaddition of ω-unsaturated nitrones

Pádár, P., Bokros, A., Paragi, G., Forgó, P., Kele, Z., Howarth, N. M. & Kovács, L., 27 Oct 2006, In : Journal of Organic Chemistry. 71, 22, p. 8669-8672 4 p.

Research output: Contribution to journalArticle

2005

An intramolecular 1,3-dipolar cycloaddition reaction towards the synthesis of chiral azetidine nucleoside analogues: The D-gluco case

Pádár, P., Forgó, P., Kele, Z., Howarth, N. M. & Kovács, L., 2005, In : Nucleosides, Nucleotides and Nucleic Acids. 24, 5-7, p. 743-745 3 p.

Research output: Contribution to journalArticle

Benzyl 2-amino-6-chloro-9H-purine-9-carboxylate

Adebambo, K. F., Howarth, N. M. & Rosair, G. M., Feb 2005, In : Acta Crystallographica Section E: Structure Reports Online. 61, 2, p. o486-o488

Research output: Contribution to journalArticle

Determination of liposome-water partition coefficients of pharmaceutical drugs using a simple laboratory titrator

Kraft, A., Howarth, N. M., Evans, R., Yeboah, A. A. & Gouzin, L., 28 Aug 2005, p. U2743-U2744. 2 p.

Research output: Contribution to conferenceAbstract

Intramolecular 1,3-dipolar cycloaddition of unsaturated nitrones derived from methyl α-d-glucopyranoside

Pádár, P., Hornyák, M., Forgó, P., Kele, Z., Paragi, G., Howarth, N. M. & Kovács, L., 11 Jul 2005, In : Tetrahedron. 61, 28, p. 6816-6823 8 p.

Research output: Contribution to journalArticle

Lipophilic peptide nucleic acids containing a 1,3-diyne function: Synthesis, characterization and production of derived polydiacetylene liposomes

Howarth, N. M., Lindsell, W. E., Murray, E. & Preston, P. N., 12 Sep 2005, In : Tetrahedron. 61, 37, p. 8875-8887 13 p.

Research output: Contribution to journalArticle

2004

Determining log P of ionisable pharmaceutical drugs by acid-base titrations.

Kraft, A., Howarth, N. M., Barzanti, C., Levet, E. & Kean, G., 28 Mar 2004, p. U151-U151. 1 p.

Research output: Contribution to conferenceAbstract

Experimental and ab initio computational studies of self-association: 2-Aminopyridine and 3-aminopyridine

Boyd, A. S. F., Frost, M. J. & Howarth, N. M., 21 Jan 2004, In : Journal of Molecular Structure. 688, 1-3, p. 149-158 10 p.

Research output: Contribution to journalArticle

2003

a-cycloPNA: l-aminocyclopentane-l-carboxylic acid derived peptide nucleic acid

Howarth, N. M., Walker, D. M. & Wakelin, L. P. G., 2003, In : Nucleosides, Nucleotides and Nucleic Acids. 22, p. 1351-1353 3 p.

Research output: Contribution to journalArticle

Conformationally restricted chiral peptide nucleic acids derived from azetidines

Kovács, L., Hornyák, M. & Howarth, N. M., 2003, In : Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, p. 1363-1365 3 p.

Research output: Contribution to journalArticle

Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid

Howarth, N. M., Lindsell, W. E., Murray, E. & Preston, P. N., 27 Oct 2003, In : Tetrahedron Letters. 44, 44, p. 8089-8092 4 p.

Research output: Contribution to journalArticle

Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10, 12-diynoic acid

Howarth, N. M., Lindsell, E., Murray, E. & Preston, P. N., 2003, In : Tetrahedron Letters. 44, p. 8089-8092 4 p.

Research output: Contribution to journalArticle

Synthesis of the four diastereoisomers of 3-thymine-1-(tbutoxycarbonyl)aminocyclopentane-1-carboxylic acid

Howarth, N. M., Wakelin, L. P. G. & Walker, D. M., 20 Jan 2003, In : Tetrahedron Letters. 44, 4, p. 695-698 4 p.

Research output: Contribution to journalArticle

Synthesis of the four diastereoisomers of 3-thymine-l-(tbutoxycarb onyl)aminocyclopentane-l-carboxylic acid

Howarth, N. M., Walker, D. M. & Wakelin, L. P. G., 2003, In : Tetrahedron Letters. 44, p. 695-698 4 p.

Research output: Contribution to journalArticle

Synthesis of thymine derivatives of 4-hydroxyvaline

Abraham, A. & Howarth, N. M., 2003, In : Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, p. 675-677 3 p.

Research output: Contribution to journalArticle

α-cycloPNA: 1-Aminocylopentane-1-carboxylic acid-derived peptide nucleic acid

Howarth, N. M., Wakelin, L. P. G. & Walker, D. M., 2003, In : Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, p. 1351-1353 3 p.

Research output: Contribution to journalArticle

2002

Estrone 3-sulfate mimics, inhibitors of estrone sulfatase activity: Homology model construction and docking studies

Howarth, N. M., Purohit, A., Robinson, J. J., Vicker, N., Reed, M. J. & Potter, B. V. L., 17 Dec 2002, In : Biochemistry. 41, 50, p. 14801-14814 14 p.

Research output: Contribution to journalArticle

Estrone 3-Sulfate Mimics. Inhibitors of Estrone Sulfatase Activity: Homology Model Construction and Docking Studies

Howarth, N. M., Purohit, A., Robinson, J. J., Vicker, N., Reed, M. J. & Potter, B. V. L., 2002, In : Biochemistry.

Research output: Contribution to journalArticle

2001

Nucleosides and Nucleic Acids

Vyle, J. S. & Howarth, N. M., 2001, Organophosphorus Chemistry (Specialist Periodical Report), 2001. Vol. 31. p. 135-218 84 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

1998

Manipulation of Substituents at Nitrogen in Tropanes, Homotropanes and Dehydro- Derivatives

Howarth, N. M., Malpass, J. R. & Smith, C. R., 1998, In : Tetrahedron. 54, p. 10899-10914 16 p.

Research output: Contribution to journalArticle

Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase

Woo, L. W. L., Howarth, N. M., Purohit, A., Hejaz, H. A. M., Reed, M. J. & Potter, B. V. L., 26 Mar 1998, In : Journal of Medicinal Chemistry. 41, 7, p. 1068-1083 16 p.

Research output: Contribution to journalArticle

Steroidal and Non-steroidal Sulfamates as Potent Inhibitors of Steroid Sulfatase

Woo, L. W. L., Howarth, N. M., Purohit, A., Hejaz, H. A. M., Reed, M. J. & Potter, B. V. L., 1998, In : Journal of Medicinal Chemistry. 41, p. 1068-1083 16 p.

Research output: Contribution to journalArticle

1997

Alpha-PNA: A Novel Peptide Nucleic Acid Analogue of DNA

Howarth, N. M. & Wakelin, L. P. G., 1997, In : J. Org. Chem.. 62, p. 5441-5450 10 p.

Research output: Contribution to journalArticle

Estrone Sulphonates as Inhibitors of Estrone Sulphatase

Howarth, N. M., Purohit, A., Reed, M. J. & Potter, B. V. L., 1997, In : Steroids. 62, p. 346-350 5 p.

Research output: Contribution to journalArticle

1996

DNA Threading Agents. Effect of Sidechain Bulk on DNA Binding and Cytotoxicity of 9-anilinoacridine-4-carboxamides

Searcey, M., Howarth, N. M., Madden, B. & Wakelin, L. P. G., 1996, In : Bioorganic and Medicinal Chemistry Letters. 6, p. 1831-1836 6 p.

Research output: Contribution to journalArticle

1995

Inactivation of Steroid Sulfatase by an Active Site-Directed Inhibitor, Estrone-3-O-Sulfamate

PUROHIT, A., Williams, G. J., HOWARTH, N. M., Potter, B. V. L. & REED, M. J., 12 Sep 1995, In : Biochemistry. 34, 36, p. 11508-11514 7 p.

Research output: Contribution to journalArticle

1994

Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potential

HOWARTH, N. M., Purohit, A., REED, M. J. & Potter, B. V. L., 21 Jan 1994, In : Journal of Medicinal Chemistry. 37, 2, p. 219-221 3 p.

Research output: Contribution to journalArticle