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2020

PIK3CA mutation enrichment and quantitation from blood and tissue

Keraite, I., Alvarez-Garcia, V., Garcia-Murillas, I., Beaney, M., Turner, N. C., Bartos, C., Oikonomidou, O., Kersaudy-Kerhoas, M. & Leslie, N. R., 13 Oct 2020, In : Scientific Reports. 10, 17082.

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2019

Mechanisms of PTEN loss in cancer: it’s all about diversity

Álvarez-Garcia, V., Tawil, Y., Wise, H. M. & Leslie, N. R., Dec 2019, In : Seminars in Cancer Biology. 59, p. 66-79 14 p.

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25 Citations (Scopus)
15 Downloads (Pure)

PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage

Zhang, J., Lee, Y-R., Dang, F., Gan, W., Menon, A. V., Katon, J. M., Hsu, C-H., Asara, J. M., Tibarewal, P., Leslie, N. R., Shi, Y., Pandolfi, P. P. & Wei, W., Sep 2019, In : Cancer discovery. 9, 9, p. 1306-1323 18 p.

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15 Citations (Scopus)
2 Downloads (Pure)

SWAP70 undergoes dynamic conformational regulation at the leading edge of migrating cells

Kriplani, N., Duncan, R. R. & Leslie, N. R., Feb 2019, In : FEBS Letters. 593, 4, p. 395-405 11 p.

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2 Citations (Scopus)
2 Downloads (Pure)

Three dimensional in vitro models of cancer: bioprinting multilineage glioblastoma models

Hermida, M. A., Kumar, J. D., Laverty, K. G., Di Bartolo, A., Ardron, M., Bogomolnijs, M., Clavreul, A., Brennan, P. M., Wiegand, U. K., Melchels, F., Shu, W. & Leslie, N. R., 17 Oct 2019, In : Advances in Biological Regulation. 100658.

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4 Citations (Scopus)
2018

A simple and robust real-time qPCR method for the detection of PIK3CA mutations

Alvarez Garcia, V., Bartos, C., Keraite, I., Trivedi, U., Brennan, P. M., Gharbi, K., Kersaudy-Kerhoas, M., Gharbi, K., Oikonomidou, O. & Leslie, N. R., 9 Mar 2018, In : Scientific Reports. 8, 4290.

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5 Citations (Scopus)
55 Downloads (Pure)

Identification of a PTEN mutation with reduced protein stability, phosphatase activity, and nuclear localization in Hong Kong patients with autistic features, neurodevelopmental delays, and macrocephaly

Wong, C. W., Or, P. M. Y., Wang, Y., Li, L., Li, J., Yan, M., Cao, Y., Luk, H. M., Tong, T. M. F., Leslie, N. R., Lo, I. F. M., Choy, K. W. & Chan, A. M. L., 2 Apr 2018, In : Autism Research.

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4 Citations (Scopus)
48 Downloads (Pure)
2017

GSK3 and its interactions with the PI3K/AKT/mTOR signalling network

Hermida, M. A., Kumar, J. D. & Leslie, N. R., Aug 2017, In : Advances in Biological Regulation. 65, p. 5-15 11 p.

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113 Citations (Scopus)
252 Downloads (Pure)

Importin-11 keeps PTEN safe from harm

Leslie, N. R., Mar 2017, In : Journal of Cell Biology. 216, 3, p. 539-541 3 p.

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16 Downloads (Pure)

Prostate cancer, PI3K, PTEN and prognosis

Wise, H. M., Hermida Ayala, M. & Leslie, N. R., Feb 2017, In : Clinical Science. 131, 3, p. 197-210 14 p.

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61 Citations (Scopus)
73 Downloads (Pure)
2016

Controlling PTEN (Phosphatase and Tensin Homolog) Stability: a Dominant Role for Lysine 66

Gupta, A. & Leslie, N. R., 26 Aug 2016, In : Journal of Biological Chemistry. 291, 35, p. 18465-18473 9 p.

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9 Citations (Scopus)
47 Downloads (Pure)

Inherited PTEN mutations and the prediction of phenotype

Leslie, N. R. & Longy, M., Apr 2016, In : Seminars in Cell and Developmental Biology. 52, p. 30-38 9 p.

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44 Citations (Scopus)
75 Downloads (Pure)

The PTEN protein: Cellular localization and post-translational regulation

Leslie, N. R., Kriplani, N., Hermida Ayala, M., Alvarez-Garcia, V. & Wise, H. M., 15 Feb 2016, In : Biochemical Society Transactions. 44, 1, p. 273-278 6 p.

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25 Citations (Scopus)
13 Downloads (Pure)
2015

Assaying PTEN catalysis in vitro

Spinelli, L. & Leslie, N. R., 1 May 2015, In : Methods. 77-78, p. 51-57 7 p.

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6 Citations (Scopus)
106 Downloads (Pure)

Class I PI 3-kinases: Function and evolution

Kriplani, N., Hermida Ayala, M., Brown, E. R. & Leslie, N. R., Sep 2015, In : Advances in Biological Regulation. 59, p. 53-64 12 p.

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40 Citations (Scopus)
137 Downloads (Pure)

Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

Spinelli, L., Black, F. M., Berg, J. N., Eickholt, B. J. & Leslie, N. R., Feb 2015, In : Journal of Medical Genetics. 52, 2, p. 128-134 7 p.

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50 Citations (Scopus)
66 Downloads (Pure)

PTEN inhibitors: An evaluation of current compounds

Spinelli, L., Lindsay, Y. E. & Leslie, N. R., Jan 2015, In : Advances in Biological Regulation. 57, p. 102-111 10 p.

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47 Citations (Scopus)
31 Downloads (Pure)

PTEN regulates IGF-1R-mediated therapy resistance in melanoma

Wang, J., Sinnberg, T., Niessner, H., Dölker, R., Sauer, B., Kempf, W. E., Meier, F., Leslie, N. & Schittek, B., Sep 2015, In : Pigment Cell and Melanoma Research. 28, 5, p. 572-589 18 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Three-dimensional bioprinting of complex cell laden alginate hydrogel structures

Ghanizadeh Tabriz, A., Hermida Ayala, M., Leslie, N. R. & Shu, W., 22 Dec 2015, In : Biofabrication. 7, 4, 11 p., 045012.

Research output: Contribution to journalArticle

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136 Citations (Scopus)
148 Downloads (Pure)

Yeast-based methods to assess PTEN phosphoinositide phosphatase activity in vivo

Rodriguez-Escudero, I., Fernandez-Acero, T., Bravo, I., Leslie, N. R., Pulido, R., Molina, M. & Cid, V. J., 1 May 2015, In : Methods. 77-78, p. 172-179 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2014

A unified nomenclature and amino acid numbering for human PTEN

Pulido, R., Baker, S. J., Barata, J. T., Carracedo, A., Cid, V. J., Chin-Sang, I. D., Davé, V., Den Hertog, J., Devreotes, P., Eickholt, B. J., Eng, C., Furnari, F. B., Georgescu, M. M., Gericke, A., Hopkins, B., Jiang, X., Lee, S. R., Lösche, M., Malaney, P., Matias-Guiu, X. & 19 others, Molina, M., Pandolfi, P. P., Parsons, R., Pinton, P., Rivas, C., Rocha, R. M., Rodríguez, M. S., Ross, A. H., Serrano, M., Stambolic, V., Stiles, B., Suzuki, A., Tan, S. S., Tonks, N. K., Trotman, L. C., Wolff, N., Woscholski, R., Wu, H. & Leslie, N. R., 1 Jul 2014, In : Science Signaling. 7, 332, pe15.

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38 Citations (Scopus)
12 Downloads (Pure)

Mutant PTEN in cancer: Worse than nothing

Leslie, N. R. & Den Hertog, J., 24 Apr 2014, In : Cell. 157, 3, p. 527-529 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

PDK1 controls upstream PI3K expression and PIP3 generation

Dieterle, A. M., Böhler, P., Keppeler, H., Alers, S., Berleth, N., Drießen, S., Hieke, N., Pietkiewicz, S., Löffler, A. S., Peter, C., Gray, A., Leslie, N. R., Shinohara, H., Kurosaki, T., Engelke, M., Wienands, J., Bonin, M., Wesselborg, S. & Stork, B., 5 Jun 2014, In : Oncogene. 33, 23, p. 3043-3053 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. & Hardie, D. G., 15 Apr 2014, In : Biochemical Journal. 459, 2, p. 275-287 13 p.

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97 Citations (Scopus)
15 Downloads (Pure)
2013

C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy

Koh, A., Lee, M. N., Yang, Y. R., Jeong, H., Ghim, J., Noh, J., Kim, J., Ryu, D., Park, S., Song, P., Koo, S-H., Leslie, N. R., Berggren, P-O., Choi, J. H., Suh, P-G. & Ryu, S. H., Apr 2013, In : Molecular and Cellular Biology. 33, 8, p. 1608-1620 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Cell biology. Where is PTEN?

Leslie, N. R. & Brunton, V. G., 26 Jul 2013, In : Science. 341, 6144, p. 355-356 2 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

MC1R Is a potent regulator of PTEN after UV exposure in melanocytes

Cao, J., Wan, L., Hacker, E., Dai, X., Lenna, S., Jimenez-Cervantes, C., Wang, Y., Leslie, N. R., Xu, G. X., Widlund, H. R., Ryu, B., Alani, R. M., Dutton-Regester, K., Goding, C. R., Hayward, N. K., Wei, W. & Cui, R., 22 Aug 2013, In : Molecular Cell. 51, 4, p. 409-422 14 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Phosphorylation of the actin binding protein Drebrin at S647 and is regulated by neuronal activity and PTEN

Kreis, P., Hendricusdottir, R., Kay, L., Papageorgiou, I. E., van Diepen, M., Mack, T., Ryves, J., Harwood, A., Leslie, N. R., Kann, O., Parsons, M. & Eickholt, B. J., 5 Aug 2013, In : PLoS ONE. 8, 8, p. e71957

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27 Citations (Scopus)
177 Downloads (Pure)
2012

Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1

Berglund, F. M., Weerasinghe, N., Davidson, L., Lim, J. C., Eickholt, B. J. & Leslie, N. R., 22 Oct 2012, In : Oncogene.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases

Leslie, N. R., Dixon, M. J., Schenning, M., Gray, A. & Batty, I. H., Jan 2012, In : Advances in Biological Regulation. 52, 1, p. 205-213 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold

Dixon, M. J., Gray, A., Schenning, M., Agacan, M., Tempel, W., Tong, Y., Nedyalkova, L., Park, H-W., Leslie, N. R., van Aalten, D. M. F., Downes, C. P. & Batty, I. H., 29 Jun 2012, In : Journal of Biological Chemistry. 287, 27, p. 22483-96 14 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

PTEN: an intercellular peacekeeper?

Leslie, N. R., 13 Nov 2012, In : Science Signaling. 5, 250, p. pe50

Research output: Contribution to journalArticle

11 Citations (Scopus)

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., Perera, N. M., Davidson, L., Barton, G. J. & Leslie, N. R., 2012, In : Science Signaling. 5, 213, p. ra18

Research output: Contribution to journalArticle

76 Citations (Scopus)

The PTEN and Myotubularin Phosphoinositide 3-Phosphatases: Linking Lipid Signalling to Human Disease

Davies, E. M., Sheffield, D. A., Tibarewal, P., Fedele, C. G., Mitchell, C. A. & Leslie, N., 2012, In : Subcellular Biochemistry. 58, p. 281-336 56 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2011

A screen for novel phosphoinositide 3-kinase effector proteins

Dixon, M. J., Gray, A., Boisvert, F-M., Agacan, M., Morrice, N. A., Gourlay, R., Leslie, N. R., Downes, C. P. & Batty, I. H., Apr 2011, In : Molecular and Cellular Proteomics. 10, 4, p. M110.003178

Research output: Contribution to journalArticle

25 Citations (Scopus)

Non-genomic loss of PTEN function in cancer: not in my genes

Leslie, N. R. & Foti, M., Mar 2011, In : Trends in Pharmacological Sciences. 32, 3, p. 131-140 10 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)
2010

Indirect mechanisms of carcinogenesis via downregulation of PTEN function

Leslie, N. R., Spinelli, L., Tibarewal, P., Zilidis, G., Weerasinghe, N., Lim, J. C., Maccario, H. & Downes, C. P., 2010, In : Advances in Enzyme Regulation. 50, 1, p. 112-118 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Leptin regulates AMPA receptor trafficking via PTEN inhibition

Moult, P. R., Cross, A., Santos, S. D., Carvalho, A-L., Lindsay, Y., Connolly, C. N., Irving, A. J., Leslie, N. R. & Harvey, J., 17 Mar 2010, In : Journal of Neuroscience. 30, 11, p. 4088-4101 14 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor calyculin A

Pozuelo-Rubio, M., Leslie, N. R., Murphy, J. & MacKintosh, C., 1 Dec 2010, In : Cell Biochemistry and Biophysics. 58, 3, p. 147-156 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Migration Stimulating Factor (MSF) promotes fibroblast migration by inhibiting AKT

Ellis, I. R., Jones, S. J., Lindsay, Y., Ohe, G., Schor, A. M., Schor, S. L. & Leslie, N. R., Nov 2010, In : Cellular Signalling. 22, 11, p. 1655-1659 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN

Davidson, L., Maccario, H., Perera, N. M., Yang, X., Spinelli, L., Tibarewal, P., Glancy, B., Gray, A., Weijer, C. J., Downes, C. P. & Leslie, N. R., 2010, In : Oncogene. 29, 5, p. 687-97 11 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress

Maccario, H., Perera, N. M., Gray, A., Downes, C. P. & Leslie, N., 2010, In : Journal of Biological Chemistry. 285, 17, p. 12620-8 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2009

MyosinV controls PTEN function and neuronal cell size

van Diepen, M. T., Parsons, M., Downes, C. P., Leslie, N. R., Hindges, R. & Eickholt, B. J., 1 Oct 2009, In : Nature Cell Biology. 11, 10, p. 1191-1196 6 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

Cao, J., Schulte, J., Knight, A., Leslie, N. R., Zagozdzon, A., Bronson, R., Manevich, Y., Beeson, C. & Neumann, C. A., 20 May 2009, In : EMBO Journal. 28, 10, p. 1505-1517 13 p.

Research output: Contribution to journalArticle

232 Citations (Scopus)

P-REX2a driving tumorigenesis by PTEN inhibition

Leslie, N. R., 27 Oct 2009, In : Science Signaling. 2, 94, p. pe68

Research output: Contribution to journalArticle

6 Citations (Scopus)

The significance of PTEN's protein phosphatase activity

Leslie, N. R., Maccario, H., Spinelli, L. & Davidson, L., 2009, In : Advances in Enzyme Regulation. 49, 1, p. 190-196 7 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2008

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

Silva, A., Yunes, J. A., Cardoso, B. A., Martins, L. R., Jotta, P. Y., Abecasis, M., Nowill, A. E., Leslie, N. R., Cardoso, A. A. & Barata, J. T., 3 Nov 2008, In : Journal of Clinical Investigation. 118, 11, p. 3762-3274 13 p.

Research output: Contribution to journalArticle

309 Citations (Scopus)

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors

Steelman, L. S., Navolanic, P. M., Sokolosky, M. L., Taylor, J. R., Lehmann, B. D., Chappell, W. H., Abrams, S. L., Wong, E. W. T., Stadelman, K. M., Terrian, D. M., Leslie, N., Martelli, A. M., Stivala, F., Libra, M., Franklin, R. A. & McCubrey, J. A., 3 Jul 2008, In : Oncogene. 27, 29, p. 4086-4095 10 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)

Understanding PTEN regulation: PIP2, polarity and protein stability

Leslie, N. R., Batty, I. H., Maccario, H., Davidson, L. & Downes, C. P., 15 Sep 2008, In : Oncogene. 27, 41, p. 5464-5476 13 p.

Research output: Contribution to journalArticle

166 Citations (Scopus)

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

Green, C. J., Göransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, K. & Hundal, H. S., 10 Oct 2008, In : Journal of Biological Chemistry. 283, 41, p. 27653-27667 15 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)