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Personal profile

Research interests

Research interests include: Molecular nutrition with an emphasis on the influence of macro- and micronutrients on gene expression. Influence of food components on the fidelity of DNA replication. Metabolic networking and cell integrity signaling in Saccharomyces cerevisiae. Heterologous gene expression in the non-conventional yeast Yarrowia lipolytica.

Biography

I graduated from the University of Würzburg with a diploma (MSc) in Biology and from the University of Erlangen with a PhD in Biochemistry. As a postdoctoral fellow with Professor Norman Giles at the University of Georgia, USA I was involved in developing the first transformation system for the bread mould, Neurospora crassa. I then returned to the University of Erlangen where I led a group working on the structure of the fatty acid synthase genes of Saccharomyces cerevisiae and Rattus novegicus. I was awarded a DSc by the University of Erlangen and given the title of Professor. My first post in the UK was at the Institute of Food Research, Norwich where, as well as being Head of Yeast Genetics, I was an Honorary Lecturer at the School of Biological Sciences, University of East Anglia. At IFR I set up a group on lipogenesis with the emphasis on diet-gene interaction. I came to Heriot-Watt University in 1999 as Reader in Biochemistry and in 2000 was appointed to a Personal Chair in Biochemistry. I was Director of Research for the School of Life Sciences from 2002-2007 and during this period led both a successful SRIF3 equipment bid and succeeded in obtaining an EPSRC RCUK Academic Fellowship in Nutrition for the Food & Nutrition group in SLS. I also coordinated SLS’s application to the University of Aberdeen-led Microbiology Pooling Initiative, SULSA II ‘Host-Microbe Biology’.

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Research Output

Evidence for Separation of PRPP Production and Maintenance of Cell Wall Integrity: Two Essential Functions of the PRPP-synthesising Machinery in Saccharomyces cerevisiae

Sauvaget, M., Vavassori, S., Schweizer, L. M. & Schweizer, M., 18 Aug 2019. 1 p.

Research output: Contribution to conferenceAbstract

  • The NHR1-1 of Prs1 and the pentameric motif 284KKCPK288 of Prs3 permit multi-functionality of the PRPP synthetase in Saccharomyces cerevisiae

    Sauvaget, M., Hutton, F., Coull, R., Vavassori, S., Wang, K., Reznik, A., Chyker, T., Newfield, C. G., Euston, E., Benary, G., Schweizer, L. M. & Schweizer, M., Mar 2019, In : FEMS Yeast Research. 19, 2, 13 p., foz006.

    Research output: Contribution to journalArticle

    Open Access
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    Five genes but the loss of five amino acids disrupts PRPP

    Schweizer, M., 11 Jun 2018.

    Research output: Contribution to conferenceAbstract

  • Functional nuclear localization signal within Prs3 is essential for the maintenance of cell wall integrity

    Sauvaget, M., Reznik, A., Ugbogu, E. A., Schweizer, L. M. & Schweizer, M., 28 Aug 2017.

    Research output: Contribution to conferenceAbstract

    Impairment of cell signalling in Saccharomyces cerevisiae as a result of suboptimal PRPP synthetase activity

    Schweizer, M., Ugbogu, E. A. & Schweizer, L. M., 1 Jul 2016, p. 1.

    Research output: Contribution to conferencePaper

    Activities