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Personal profile

Research interests

Research interests include: Molecular nutrition with an emphasis on the influence of macro- and micronutrients on gene expression. Influence of food components on the fidelity of DNA replication. Metabolic networking and cell integrity signaling in Saccharomyces cerevisiae. Heterologous gene expression in the non-conventional yeast Yarrowia lipolytica.

Biography

I graduated from the University of Würzburg with a diploma (MSc) in Biology and from the University of Erlangen with a PhD in Biochemistry. As a postdoctoral fellow with Professor Norman Giles at the University of Georgia, USA I was involved in developing the first transformation system for the bread mould, Neurospora crassa. I then returned to the University of Erlangen where I led a group working on the structure of the fatty acid synthase genes of Saccharomyces cerevisiae and Rattus novegicus. I was awarded a DSc by the University of Erlangen and given the title of Professor. My first post in the UK was at the Institute of Food Research, Norwich where, as well as being Head of Yeast Genetics, I was an Honorary Lecturer at the School of Biological Sciences, University of East Anglia. At IFR I set up a group on lipogenesis with the emphasis on diet-gene interaction. I came to Heriot-Watt University in 1999 as Reader in Biochemistry and in 2000 was appointed to a Personal Chair in Biochemistry. I was Director of Research for the School of Life Sciences from 2002-2007 and during this period led both a successful SRIF3 equipment bid and succeeded in obtaining an EPSRC RCUK Academic Fellowship in Nutrition for the Food & Nutrition group in SLS. I also coordinated SLS’s application to the University of Aberdeen-led Microbiology Pooling Initiative, SULSA II ‘Host-Microbe Biology’.

Fingerprint Dive into the research topics where Michael Schweizer is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Fatty Acid Synthases Medicine & Life Sciences
Saccharomyces cerevisiae Medicine & Life Sciences
Sterol Regulatory Element Binding Protein 1 Medicine & Life Sciences
Cell Wall Medicine & Life Sciences
Genes Medicine & Life Sciences
Ribose-Phosphate Pyrophosphokinase Medicine & Life Sciences
Yeasts Medicine & Life Sciences
Binding Sites Medicine & Life Sciences

Co Author Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1996 2019

Evidence for Separation of PRPP Production and Maintenance of Cell Wall Integrity: Two Essential Functions of the PRPP-synthesising Machinery in Saccharomyces cerevisiae

Sauvaget, M., Vavassori, S., Schweizer, L. M. & Schweizer, M., 18 Aug 2019. 1 p.

Research output: Contribution to conferenceAbstract

Cell Wall
Saccharomyces cerevisiae
Maintenance
Yeasts
Phosphotransferases
1 Downloads (Pure)

The NHR1-1 of Prs1 and the pentameric motif 284KKCPK288 of Prs3 permit multi-functionality of the PRPP synthetase in Saccharomyces cerevisiae

Sauvaget, M., Hutton, F., Coull, R., Vavassori, S., Wang, K., Reznik, A., Chyker, T., Newfield, C. G., Euston, E., Benary, G., Schweizer, L. M. & Schweizer, M., Mar 2019, In : FEMS Yeast Research. 19, 2, 13 p., foz006.

Research output: Contribution to journalArticle

Open Access
File
Ribose-Phosphate Pyrophosphokinase
Cell Wall
Saccharomyces cerevisiae
Kinetochores
Gene Duplication

Five genes but the loss of five amino acids disrupts PRPP

Schweizer, M., 11 Jun 2018.

Research output: Contribution to conferenceAbstract

Cell Wall
Caffeine
Amino Acids
Maintenance
Genes

Functional nuclear localization signal within Prs3 is essential for the maintenance of cell wall integrity

Sauvaget, M., Reznik, A., Ugbogu, E. A., Schweizer, L. M. & Schweizer, M., 28 Aug 2017.

Research output: Contribution to conferenceAbstract

Impairment of cell signalling in Saccharomyces cerevisiae as a result of suboptimal PRPP synthetase activity

Schweizer, M., Ugbogu, E. A. & Schweizer, L. M., 1 Jul 2016, p. 1.

Research output: Contribution to conferencePaper

Activities 2007 2020

  • 7 Invited talk
  • 5 Other
  • 2 Oral presentation
  • 1 Editorial activity

International Journal of Molecular Sciences (Journal)

Michael Schweizer (Editorial board member)
1 Jan 20201 Jan 2023

Activity: Publication peer-review and editorial workEditorial activity

Functional nuclear localization signal within Prs3 is essential for the maintenance of cell wall integrity

Michael Schweizer (Speaker)
27 Aug 20171 Sep 2017

Activity: Talk or presentationInvited talk