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Research Output 2005 2019

  • 23 Article
  • 3 Conference contribution
  • 1 Chapter
  • 1 Review article
2019

A low inflammatory, Langerhans cell-targeted microprojection patch to deliver ovalbumin to the epidermis of mouse skin

van der Burg, N. M. D., Depelsenaire, A. C. I., Crichton, M. L., Kuo, P., Phipps, S. & Kendall, M. A. F., 28 May 2019, In : Journal of Controlled Release. 302, p. 190-200 11 p.

Research output: Contribution to journalArticle

Langerhans Cells
Ovalbumin
Epidermis
Skin
Erythema

Cellular metabolism and pore lifetime of human skin following microprojection array mediation

Haridass, I. N., Wei, J. C. J., Mohammed, Y. H., Crichton, M. L., Anderson, C. D., Henricson, J., Sanchez, W. Y., Meliga, S. C., Grice, J. E., Benson, H. A. E., Kendall, M. A. F. & Roberts, M. S., 28 Jul 2019, In : Journal of Controlled Release. 306, p. 59-68 10 p.

Research output: Contribution to journalArticle

Immune response and reactogenicity of an unadjuvanted intradermally delivered human papillomavirus vaccine using a first generation Nanopatch™ in rhesus macaques: An exploratory, pre-clinical feasibility assessment

Meyer, B. K., Kendall, M. A. F., Williams, D. M., Bett, A. J., Dubey, S., Gentzel, R. C., Casimiro, D., Forster, A., Corbett, H., Crichton, M., Baker, S. B., Evans, R. K. & Bhambhani, A., 9 Aug 2019, In : Vaccine: X. 2, 100030.

Research output: Contribution to journalArticle

Open Access
File
Papillomavirus Vaccines
Papillomaviridae
Macaca mulatta
immune response
vaccines
2018

Sensors for foetal hypoxia and metabolic acidosis: a review

Cummins, G., Kremer, J., Bernassau, A., Brown, A., Bridle, H., Schulze, H., Bachmann, T., Crichton, M., Denison, F. C. & Desmulliez, M. P. Y., 13 Aug 2018, In : Sensors. 18, 8, 2648.

Research output: Contribution to journalReview article

Open Access
File
Fetal Hypoxia
Fetal Monitoring
Acidosis
Lactic Acid
Fetal Heart Rate

Space- and time-resolved investigation on diffusion kinetics of human skin following macromolecule delivery by microneedle arrays

Wei, J. C. J., Haridass, I. N., Crichton, M., Mohammed, Y. H., Meliga, S. C., Sanchez, W. Y., Grice, J. E., Benson, H. A. E., Roberts, M. S. & Kendall, M. A. F., 10 Dec 2018, In : Scientific Reports. 8, 17759.

Research output: Contribution to journalArticle

Open Access
File
Skin
Equipment and Supplies
Vaccines
Knowledge Bases
Antigen-Presenting Cells
2017

Allometric scaling of skin thickness, elasticity, viscoelasticity to mass for micro-medical device translation: From mice, rats, rabbits, pigs to humans

Wei, J. C. J., Edwards, G. A., Martin, D. J., Huang, H., Crichton, M. L. & Kendall, M. A. F., 21 Nov 2017, In : Scientific Reports. 7, 15885.

Research output: Contribution to journalArticle

Open Access
File
Elasticity
Swine
Rabbits
Equipment and Supplies
Skin

Nanopatches for Vaccine Delivery

Crichton, M. L. & Kendall, M. A. F., 2017, Micro- and Nanotechnology in Vaccine Development. Elsevier, p. 343-356 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vaccines
Refrigeration
Needles
Vaccination
Equipment and Supplies

The hyperelastic and failure behaviors of skin in relation to the dynamic application of microscopic penetrators in a murine model

Meliga, S. C., Coffey, J. W., Crichton, M. L., Flaim, C., Veidt, M. & Kendall, M. A. F., 15 Jan 2017, In : Acta Biomaterialia. 48, p. 341-356 16 p.

Research output: Contribution to journalArticle

Skin
Mechanics
Indentation
Equipment and Supplies
Stress Fractures
2016

Characterising the material properties at the interface between skin and a skin vaccination microprojection device

Crichton, M. L., Archer-Jones, C., Meliga, S., Edwards, G., Martin, D., Huang, H. & Kendall, M. A. F., May 2016, In : Acta Biomaterialia. 36, p. 186-194 9 p.

Research output: Contribution to journalArticle

Materials properties
Skin
Vaccination
Equipment and Supplies
Punctures

Formulations for microprojection/microneedle vaccine delivery: Structure, strength and release profiles

Raphael, A. P., Crichton, M. L., Falconer, R. J., Meliga, S., Chen, X., Fernando, G. J. P., Huang, H. & Kendall, M. A. F., 10 Mar 2016, In : Journal of Controlled Release. 225, p. 40-52 13 p.

Research output: Contribution to journalArticle

Sorbitol
Trehalose
Synchrotrons
Vaccines
Excipients

Inactivated poliovirus type 2 vaccine delivered to rat skin via high density microprojection array elicits potent neutralising antibody responses

Muller, D. A., Pearson, F. E., Fernando, G. J. P., Agyei-Yeboah, C., Owens, N. S., Corrie, S. R., Crichton, M. L., Wei, J. C. J., Weldon, W. C., Oberste, M. S., Young, P. R. & Kendall, M. A. F., 25 Feb 2016, In : Scientific Reports. 6, 22094.

Research output: Contribution to journalArticle

Open Access
File
Inactivated Poliovirus Vaccine
Poliovirus
Neutralizing Antibodies
Antibody Formation
Oral Poliovirus Vaccine

The changing shape of vaccination: Improving immune responses through geometrical variations of a microdevice for immunization

Crichton, M. L., Muller, D. A., Depelsenaire, A. C. I., Pearson, F. E., Wei, J., Coffey, J., Zhang, J., Fernando, G. J. P. & Kendall, M. A. F., 2 Jun 2016, In : Scientific Reports. 6, 27217.

Research output: Contribution to journalArticle

Open Access
File
Immunization
Vaccination
Skin
Equipment and Supplies
Influenza Vaccines
2014

Microprojection arrays to immunise at mucosal surfaces

McNeilly, C. L., Crichton, M. L., Primiero, C. A., Frazer, I. H., Roberts, M. S. & Kendall, M. A. F., 28 Dec 2014, In : Journal of Controlled Release. 196, p. 252-260 9 p.

Research output: Contribution to journalArticle

Mouth Mucosa
Vaccines
Cheek
Influenza Vaccines
Antigen-Presenting Cells
2013

Dry-Coated Live Viral Vector Vaccines Delivered by Nanopatch Microprojections Retain Long-Term Thermostability and Induce Transgene-Specific T Cell Responses in Mice

Pearson, F. E., McNeilly, C. L., Crichton, M. L., Primiero, C. A., Yukiko, S. R., Fernando, G. J. P., Chen, X., Gilbert, S. C., Hill, A. V. S. & Kendall, M. A. F., 9 Jul 2013, In : PLoS ONE. 8, 7, e67888.

Research output: Contribution to journalArticle

Open Access
Viral Vaccines
vector vaccines
T-cells
thermal stability
Transgenes

Elastic modulus and viscoelastic properties of full thickness skin characterised at micro scales

Crichton, M. L., Chen, X., Huang, H. & Kendall, M. A. F., Mar 2013, In : Biomaterials. 34, 8, p. 2087-2097 11 p.

Research output: Contribution to journalArticle

Elastic Modulus
Skin
Elastic moduli
Cells
Vaccines
2011

Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization

Chen, X., Fernando, G. J. P., Crichton, M. L., Flaim, C., Yukiko, S. R., Fairmaid, E. J., Corbett, H. J., Primiero, C. A., Ansaldo, A. B., Frazer, I. H., Brown, L. E. & Kendall, M. A. F., 30 Jun 2011, In : Journal of Controlled Release. 152, 3, p. 349-355 7 p.

Research output: Contribution to journalArticle

Needles
Vaccines
Equipment and Supplies
Influenza Vaccines
Refrigeration

The viscoelastic, hyperelastic and scale dependent behaviour of freshly excised individual skin layers

Crichton, M. L., Donose, B. C., Chen, X., Raphael, A. P., Huang, H. & Kendall, M. A. F., Jul 2011, In : Biomaterials. 32, 20, p. 4670-4681 12 p.

Research output: Contribution to journalArticle

Indentation
Epidermis
Skin
Dermis
Vaccines
2010

Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin

Chen, X., Fernando, G. J. P., Corbett, H., Prow, T. W., Crichton, M. L. & Crichton, M. A. F., 2010, ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology. Piscataway (New Jersey): IEEE, p. 358-361 4 p. 6045237

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Vaccines
Skin
Evaporation
Coatings
Pandemics

Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays

Chen, X., Kask, A. S., Crichton, M. L., McNeilly, C., Yukiko, S., Dong, L., Marshak, J. O., Jarrahian, C., Fernando, G. J. P., Chen, D., Koelle, D. M. & Kendall, M. A. F., 20 Dec 2010, In : Journal of Controlled Release. 148, 3, p. 327-333 7 p.

Research output: Contribution to journalArticle

DNA Vaccines
Human Herpesvirus 2
Antigen-Presenting Cells
Vaccination
Vaccines

Nanopatch-targeted skin vaccination against West Nile virus and chikungunya virus in mice

Prow, T. W., Chen, X., Prow, N. A., Fernando, G. J. P., Tan, C. S. E., Raphael, A. P., Chang, D., Ruutu, M. P., Jenkins, D. W. K., Pyke, A., Crichton, M. L., Raphaelli, K., Goh, L. Y. H., Frazer, I. H., Roberts, M. S., Gardner, J., Khromykh, A. A., Suhrbier, A., Hall, R. A. & Kendall, M. A. F., 12 Aug 2010, In : Small. 6, 16, p. 1776-1784 9 p.

Research output: Contribution to journalArticle

Chikungunya virus
West Nile virus
Vaccines
Antigen-Presenting Cells
Viruses

Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model

Fernando, G. J. P., Chen, X., Prow, T. W., Crichton, M. L., Fairmaid, E. J., Roberts, M. S., Frazer, I. H., Brown, L. E. & Kendall, M. A. F., 21 Apr 2010, In : PLoS ONE. 5, 4, 11 p., e10266.

Research output: Contribution to journalArticle

Open Access
Influenza Vaccines
skin (animal)
influenza
Immunity
Skin

Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding

Corrie, S. R., Fernando, G. J. P., Crichton, M. L., Brunck, M. E. G., Anderson, C. D. & Kendall, M. A. F., 21 Oct 2010, In : Lab on a Chip. 10, 20, p. 2655-2658 4 p.

Research output: Contribution to journalArticle

Syringes
Biomarkers
Antigens
Protein Binding
Antibodies

Targeted, needle-free vaccinations in skin using multilayered, densely-packed dissolving microprojection arrays

Raphael, A. P., Prow, T. W., Crichton, M. L., Chen, X., Fernando, G. J. P. & Kendall, M. A. F., 12 Aug 2010, In : Small. 6, 16, p. 1785-1793 9 p.

Research output: Contribution to journalArticle

Vaccines
Needles
Syringes
Skin
Vaccination

The effect of strain rate on the precision of penetration of short densely-packed microprojection array patches coated with vaccine

Crichton, M. L., Ansaldo, A., Chen, X., Prow, T. W., Fernando, G. J. P. & Kendall, M. A. F., Jun 2010, In : Biomaterials. 31, 16, p. 4562-4572 11 p.

Research output: Contribution to journalArticle

Vaccines
Strain rate
Skin
Langerhans Cells
Antigens
2009

Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin

Chen, X., Prow, T. W., Crichton, M. L., Jenkins, D. W. K., Roberts, M. S., Frazer, I. H., Fernando, G. J. P. & Kendall, M. A. F., 3 Nov 2009, In : Journal of Controlled Release. 139, 3, p. 212-220 9 p.

Research output: Contribution to journalArticle

Vaccines
Skin
Needles
Intramuscular Injections
Ovalbumin
2008

Novel coating of micro-nanoprojection patches for targeted vaccine delivery to skin

Chen, X., Prow, T. W., Crichton, M. L., Fernando, G. J. P. & Kendall, M. A. F., 2008, Proceedings of the 2008 International Conference on Nanoscience and Nanotechnology, ICONN 2008. Piscataway, New Jersey, p. 105-108 4 p. 4639257

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Vaccines
Skin
Coatings

Targeted epidermal delivery of vaccines from coated micro-nanoprojection patches

Prow, T. W., Chen, X., Crichton, M., Tiwari, Y., Gradassi, F., Raphelli, K., Mahony, D., Fernando, G., Roberts, M. S. & Kendall, M. A. F., 2008, Proceedings of the 2008 International Conference on Nanoscience and Nanotechnology, ICONN 2008. Piscataway, New Jersey, p. 125-128 4 p. 4639262

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nanoneedles
Vaccines
Epidermis
Immunization
Safety
2005

A systematic study of side-wall interference effects on delta wing aerodynamics

Crichton, M. L., Czarnecka, Z., Green, R. B. & Coton, F. N., 2005, In : Collection of Technical Papers - AIAA Applied Aerodynamics Conference. 2, p. 935-945 11 p.

Research output: Contribution to journalArticle

Aerodynamics
Vortex flow
Wind tunnels
Geometry
Flow visualization