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Personal profile

Research interests

Michael’s research takes a multi-disciplinary approach to the development of novel biomedical devices centred around a strong understanding of soft-tissue biomechanics on the micron-scale.  Within this realm, his work is then focussed on the following areas:

  1. Understanding the fundamental properties of tissue biomechanics and how they are perturbed;
  2. Microfabrication of minimally-invasive sensing technologies for health and disease;
  3. Biomimetic ways to interact with tissues and how this can be used to develop new materials etc.

The main goal of Michael’s research is to develop simple, effective technology for patient health using a materials-based, micron-scale approach.

Biography

Michael was born and grew up in Edinburgh prior to moving to Glasgow to undertake his undergraduate degree.  He completed an undergraduate Masters at the University of Glasgow in Aeronautical Engineering (MEng (hons)), and then spent a short time in the aerospace industry before moving to Brisbane, Australia to complete a PhD.  He completed this at the University of Queensland in Biomedical Engineering, working on a microneedle vaccine technology (the Nanopatch).   His work in this area led to a number of publications, conference presentations and patents which were licenced to Vaxxas Pty Ltd, a start-up company established with $15m funding to commercialise this technology. 

In 2011 Michael joined Vaxxas as a foundational team member working on a variety of projects and leading aspects of the device development engineering.  Although he enjoyed this role he chose to return to academic research in 2014 where he has been establishing new lines of research in the area of microdevices for health.

In late 2017 Michael returned to Scotland where he joined Heriot-Watt University’s School of Engineering and Physical Sciences as an Assistant Professor in Biomedical Engineering.  In this position he is building his research program focussed on simple microtechnolgies for tissue-based measurement and sensing.  He is also involved in teaching on the undergraduate engineering programmes within the school.

Research Group Contact Details

Email: M.Crichton@hw.ac.uk

Phone: 0131 451 4367

Keywords

  • TJ Mechanical engineering and machinery
  • Biomedical Engineering
  • microfabrication
  • Tissue biomechanics
  • mechanobiology

Fingerprint Dive into the research topics where Michael Crichton is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Skin Medicine & Life Sciences
Vaccines Medicine & Life Sciences
Needles Medicine & Life Sciences
Vaccination Medicine & Life Sciences
Equipment and Supplies Medicine & Life Sciences
Epidermis Medicine & Life Sciences
Antigen-Presenting Cells Medicine & Life Sciences
Syringes Medicine & Life Sciences

Co Author Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2005 2019

  • 23 Article
  • 3 Conference contribution
  • 1 Chapter
  • 1 Review article

A low inflammatory, Langerhans cell-targeted microprojection patch to deliver ovalbumin to the epidermis of mouse skin

van der Burg, N. M. D., Depelsenaire, A. C. I., Crichton, M. L., Kuo, P., Phipps, S. & Kendall, M. A. F., 28 May 2019, In : Journal of Controlled Release. 302, p. 190-200 11 p.

Research output: Contribution to journalArticle

Langerhans Cells
Ovalbumin
Epidermis
Skin
Erythema

Cellular metabolism and pore lifetime of human skin following microprojection array mediation

Haridass, I. N., Wei, J. C. J., Mohammed, Y. H., Crichton, M. L., Anderson, C. D., Henricson, J., Sanchez, W. Y., Meliga, S. C., Grice, J. E., Benson, H. A. E., Kendall, M. A. F. & Roberts, M. S., 28 Jul 2019, In : Journal of Controlled Release. 306, p. 59-68 10 p.

Research output: Contribution to journalArticle

Immune response and reactogenicity of an unadjuvanted intradermally delivered human papillomavirus vaccine using a first generation Nanopatch™ in rhesus macaques: An exploratory, pre-clinical feasibility assessment

Meyer, B. K., Kendall, M. A. F., Williams, D. M., Bett, A. J., Dubey, S., Gentzel, R. C., Casimiro, D., Forster, A., Corbett, H., Crichton, M., Baker, S. B., Evans, R. K. & Bhambhani, A., 9 Aug 2019, In : Vaccine: X. 2, 100030.

Research output: Contribution to journalArticle

Open Access
File
Papillomavirus Vaccines
Papillomaviridae
Macaca mulatta
immune response
vaccines

Sensors for foetal hypoxia and metabolic acidosis: a review

Cummins, G., Kremer, J., Bernassau, A., Brown, A., Bridle, H., Schulze, H., Bachmann, T., Crichton, M., Denison, F. C. & Desmulliez, M. P. Y., 13 Aug 2018, In : Sensors. 18, 8, 2648.

Research output: Contribution to journalReview article

Open Access
File
Fetal Hypoxia
Fetal Monitoring
Acidosis
Lactic Acid
Fetal Heart Rate

Space- and time-resolved investigation on diffusion kinetics of human skin following macromolecule delivery by microneedle arrays

Wei, J. C. J., Haridass, I. N., Crichton, M., Mohammed, Y. H., Meliga, S. C., Sanchez, W. Y., Grice, J. E., Benson, H. A. E., Roberts, M. S. & Kendall, M. A. F., 10 Dec 2018, In : Scientific Reports. 8, 17759.

Research output: Contribution to journalArticle

Open Access
File
Skin
Equipment and Supplies
Vaccines
Knowledge Bases
Antigen-Presenting Cells