Graeme Whyte

2021

Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH

Kermanizadeh, A., Valli, J., Sanchez, K., Hutter, S., Pawlowska, A., Whyte, G., Moritz, W. & Stone, V., 20 Oct 2021, (E-pub ahead of print) In: Archives of Toxicology.

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2020

Image-Based Single Cell Sorting Automation in Droplet Microfluidics

Sesen, M. & Whyte, G., 26 May 2020, In: Scientific Reports. 10, 8736.

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18 Citations (Scopus)

61 Downloads (Pure)

Purifying stem cell-derived red blood cells: a high-throughput label-free downstream processing strategy based on microfluidic spiral inertial separation and membrane filtration

Guzniczak, E., Otto, O., Whyte, G., Chandra, T., Robertson, N. A., Willoughby, N., Jimenez, M. & Bridle, H., Jul 2020, In: Biotechnology and Bioengineering. 117, 7, p. 2032-2045 14 p.

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6 Citations (Scopus)

8 Downloads (Pure)

2019

Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

Kermanizadeh, A., Berthing, T., Guzniczak, E., Wheeldon, M., Whyte, G., Vogel, U., Moritz, W. & Stone, V., 19 Nov 2019, In: Particle and Fibre Toxicology. 16, 42.

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9 Citations (Scopus)

12 Downloads (Pure)

Deformability-induced lift force in spiral microchannels for cell separation

Guzniczak, E., Otto, O., Whyte, G., Willoughby, N., Jimenez, M. & Bridle, H., 23 Dec 2019, (E-pub ahead of print) In: Lab on a Chip.

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

2018

A comparison of methods to assess cell mechanical properties

Wu, P. H., Aroush, D. R. B., Asnacios, A., Chen, W. C., Dokukin, M. E., Doss, B. L., Durand-Smet, P., Ekpenyong, A., Guck, J., Guz, N. V., Janmey, P. A., Lee, J. S. H., Moore, N. M., Ott, A., Poh, Y. C., Ros, R., Sander, M., Sokolov, I., Staunton, J. R., Wang, N. & 2 others, Whyte, G. & Wirtz, D., 18 Jun 2018, In: Nature Methods. 15, p. 491-498 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

211 Citations (Scopus)

2017

High-throughput assessment of mechanical properties of stem cell derived red blood cells, toward cellular downstream processing

Guzniczak, E., Mohammad Zadeh, M., Dempsey, F., Jimenez, M., Bock, H., Whyte, G., Willoughby, N. & Bridle, H., 31 Oct 2017, In: Scientific Reports. 7, 14457.

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14 Citations (Scopus)

35 Downloads (Pure)

Image-based closed-loop feedback for highly mono-dispersed microdroplet production

Crawford, D. F., Smith, C. A. & Whyte, G., 5 Sep 2017, In: Scientific Reports. 7, 10545.

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12 Citations (Scopus)

47 Downloads (Pure)

Optomechanical measurement of the role of Lamins in whole cell deformability

Kolb, T., Kraxner, J., Skodzek, K., Haug, M., Crawford, D., Maaß, K. K., Aifantis, K. E. & Whyte, G., 9 May 2017, (E-pub ahead of print) In: Journal of Biophotonics.

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2 Citations (Scopus)

82 Downloads (Pure)

Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions

Lange, J. R., Metzner, C., Richter, S., Schneider, W., Spermann, M., Kolb, T., Whyte, G. & Fabry, B., 11 Apr 2017, In: Biophysical Journal. 112, 7, p. 1472-1480 9 p.

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26 Citations (Scopus)

87 Downloads (Pure)

2016

High-throughput screening of antibiotic-resistant bacteria in picodroplets

Liu, X., Painter, R. E., Enesa, K., Holmes, D., Whyte, G., Garlisi, C. G., Monsma, F. J., Rehak, M., Craig, F. F. & Smith, C. A., 2016, In: Lab on a Chip. 16, 9, p. 1636-1643 8 p.

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Monitoring Early-Stage Nanoparticle Assembly in Microdroplets by Optical Spectroscopy and SERS

Salmon, A. R., Esteban, R., Taylor, R. W., Hugall, J. T., Smith, C. A., Whyte, G., Scherman, O. A., Aizpurua, J., Abell, C. & Baumberg, J. J., 6 Apr 2016, In: Small. 12, 3, p. 1788–1796 9 p.

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20 Citations (Scopus)

44 Downloads (Pure)

2015

A monolithic glass chip for active single-cell sorting based on mechanical phenotyping

Faigle, C., Lautenschlager, F., Whyte, G., Homewood, P., Martin-Badosa, E. & Guck, J., 7 Mar 2015, In: Lab on a Chip. 15, p. 1267-1275

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24 Citations (Scopus)

410 Downloads (Pure)

Deformation of phospholipid vesicles in an optical stretcher

Delabre, U., Feld, K., Crespo, E., Whyte, G., Sykes, C., Seifert, U. & Guck, J., 14 Aug 2015, In: Soft Matter. 11, 30, p. 6075-6088 14 p.

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Microconstriction Arrays for High-Throughput Quantitative Measurements of Cell Mechanical Properties

Lange, J. R., Steinwachs, J., Kolb, T., Lautscham, L. A., Harder, I., Whyte, G. & Fabry, B., 2015, In: Biophysical Journal. 109, 1, p. 26-34 9 p.

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79 Citations (Scopus)

215 Downloads (Pure)

2014

Dynamically reconfigurable fibre optical spanner

Kolb, T., Albert, S., Haug, M. & Whyte, G., Feb 2014, In: Lab on a Chip. 14, p. 1186-1190 5 p.

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21 Citations (Scopus)

374 Downloads (Pure)

Dynamic operation of optical fibres beyond the single-mode regime facilitates the orientation of biological cells

Kreysing, M., Ott, D., Schmidberger, M. J., Otto, O., Schürmann, M., Martín-Badosa, E., Whyte, G. & Guck, J., 2014, In: Nature Communications. 5, 5481.

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Impact of heating on passive and active biomechanics of suspended cells

Chan, C. J., Whyte, G., Boyde, L., Salbreux, G. & Guck, J., Apr 2014, In: Interface Focus. 4, 2, p. 2013.0069 1 p.

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Optofluidic rotation of living cells for single-cell tomography

Kolb, T., Albert, S., Haug, M. & Whyte, G., 2014, In: Journal of Biophotonics.

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Separation of blood cells with differing deformability using deterministic lateral displacement

Holmes, D., Whyte, G., Bailey, J., Vergara-Irigaray, N., Ekpenyong, A., Guck, J. & Duke, T., 2014, In: Interface Focus. 4, 6, 20140011.

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

2013

Elastic theory for the deformation of a solid or layered spheroid under axisymmetric loading

Boyde, L., Ekpenyong, A., Whyte, G. & Guck, J., Apr 2013, In: Acta Mechanica. 224, 4, p. 819-839 21 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

2012

Comparison of stresses on homogeneous spheroids in the optical stretcher computed with geometrical optics and generalized Lorenz-Mie theory

Boyde, L., Ekpenyong, A., Whyte, G. & Guck, J., 20 Nov 2012, In: Applied Optics. 51, 33, p. 7934-7944 11 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Mechanical environment modulates biological properties of oligodendrocyte progenitor cells.

Jagielska, A., Norman, A. L., Whyte, G., Van Vliet, K. J., Guck, J., Franklin, R. J. M. & Vliet, K. J. V., Nov 2012, In: Stem Cells and Development. 21, 16, p. 2905-2914 10 p.

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Validation and perspectives of a femtosecond laser fabricated monolithic optical stretcher

Bellini, N., Bragheri, F., Cristiani, I., Guck, J., Osellame, R. & Whyte, G., 1 Oct 2012, In: Biomedical Optics Express. 3, 10, p. 2658-2668 11 p.

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39 Citations (Scopus)

67 Downloads (Pure)

Viscoelastic properties of differentiating blood cells are fate- and function-dependent.

Ekpenyong, A. E., Whyte, G., Chalut, K., Pagliara, S., Lautenschläger, F., Fiddler, C., Paschke, S., Keyser, U. F., Chilvers, E. R. & Guck, J., Jan 2012, In: PLoS ONE. 7, 9, p. e45237-e45237

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120 Citations (Scopus)

116 Downloads (Pure)

2010

Generation of picoliter droplets with defined contents and concentration gradients from the separation of chemical mixtures

Theberge, A. B., Whyte, G. & Huck, W. T. S., 2010, In: Analytical Chemistry. 82, 9, p. 3449-3453 5 p.

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

2009

Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays

Courtois, F., Olguin, L. F., Whyte, G., Theberge, A. B., Huck, W. T. S., Hollfelder, F. & Abell, C., 15 Apr 2009, In: Analytical Chemistry. 81, 8, p. 3008-3016 9 p.

Research output: Contribution to journal › Article › peer-review

153 Citations (Scopus)

Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.

Fidalgo, L. M., Whyte, G., Ruotolo, B. T., Benesch, J. L. P., Stengel, F., Abell, C., Robinson, C. V. & Huck, W. T. S., Jan 2009, In: Angewandte Chemie International Edition. 48, 20, p. 3665-3668 4 p.

Research output: Contribution to journal › Article › peer-review

141 Citations (Scopus)

Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments

Shim, J. U., Olguin, L. F., Whyte, G., Scott, D., Babtie, A., Abell, C., Huck, W. T. S. & Hollfelder, F., 28 Oct 2009, In: Journal of the American Chemical Society. 131, 42, p. 15251-15256 6 p.

Research output: Contribution to journal › Article › peer-review

134 Citations (Scopus)

Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays

Huebner, A., Bratton, D., Whyte, G., Yang, M., DeMello, A. J., Abell, C. & Hollfelder, F., 2009, In: Lab on a Chip. 9, 5, p. 692-698

Research output: Contribution to journal › Article › peer-review

263 Citations (Scopus)

Suzuki-Miyaura coupling reactions in aqueous microdroplets with catalytically active fluorous interfaces

Theberge, A. B., Whyte, G., Frenzel, M., Fidalgo, L. M., Wootton, R. C. R. & Huck, W. T. S., 2009, In: Chemical Communications. 2009, 41, p. 6225-6227 3 p.

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

2008

An integrated device for monitoring time-dependent in vitro expression from single genes in picolitre droplets.

Courtois, F., Olguin, L. F., Whyte, G., Bratton, D., Huck, W. T. S., Abell, C. & Hollfelder, F., 15 Feb 2008, In: ChemBioChem. 9, 3, p. 439-446 8 p.

Research output: Contribution to journal › Article › peer-review

149 Citations (Scopus)

Development of Quantitative Cell-Based Enzyme Assays in Microdroplets

Huebner, A., Olguin, L. F., Bratton, D., Whyte, G., Huck, W. T. S., De Mello, A. J., Edel, J. B., Abell, C. & Hollfelder, F., 15 May 2008, In: Analytical Chemistry. 80, 10, p. 3890-3896 7 p.

Research output: Contribution to journal › Article › peer-review

173 Citations (Scopus)

Dynamic control of higher-order modes in hollow-core photonic crystal fibers

Euser, T. G., Whyte, G., Scharrer, M., Chen, J. S. Y., Abdolvand, A., Nold, J., Kaminski, C. F. & Russell, P. S. J., 27 Oct 2008, In: Optics Express. 16, 22, p. 17972-17981

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62 Citations (Scopus)

288 Downloads (Pure)

From microdroplets to microfluidics: selective emulsion separation in microfluidic devices.

Fidalgo, L. M., Whyte, G., Bratton, D., Kaminski, C. F., Abell, C. & Huck, W. T. S., Jan 2008, In: Angewandte Chemie International Edition. 47, 11, p. 2042-2045 4 p.

Research output: Contribution to journal › Article › peer-review

136 Citations (Scopus)