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Graeme Whyte

Dr

 https://orcid.org/0000-0003-4147-2656
20042019
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Research Output 2004 2019

  • 41 Article
  • 3 Conference contribution
  • 2 Patent
  • 1 Meeting abstract
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Article
2019

Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

Kermanizadeh, A., Berthing, T., Guzniczak, E., Wheeldon, M., Whyte, G., Vogel, U., Moritz, W. & Stone, V., 19 Nov 2019, In : Particle and Fibre Toxicology. 16, 42.

Research output: Contribution to journal › Article

Open Access
File
Nanostructures
Nanostructured materials
Liver
Cytotoxicity
Aspartate Aminotransferases
2018

A comparison of methods to assess cell mechanical properties

Wu, P. H., Aroush, D. R. B., Asnacios, A., Chen, W. C., Dokukin, M. E., Doss, B. L., Durand-Smet, P., Ekpenyong, A., Guck, J., Guz, N. V., Janmey, P. A., Lee, J. S. H., Moore, N. M., Ott, A., Poh, Y. C., Ros, R., Sander, M., Sokolov, I., Staunton, J. R., Wang, N. & 2 others, Whyte, G. & Wirtz, D., 18 Jun 2018, In : Nature Methods. 15, p. 491-498 8 p.

Research output: Contribution to journal › Article

Open Access
mechanical properties
cells
organelles
cytometry
cytoplasm
2017

High-throughput assessment of mechanical properties of stem cell derived red blood cells, toward cellular downstream processing

Guzniczak, E., Mohammad Zadeh, M., Dempsey, F., Jimenez, M., Bock, H., Whyte, G., Willoughby, N. & Bridle, H., 31 Oct 2017, In : Scientific Reports. 7, 14457.

Research output: Contribution to journal › Article

Open Access
File
Stem Cells
Erythrocytes
Elastic Modulus
Cell Nucleus
Atomic Force Microscopy

Image-based closed-loop feedback for highly mono-dispersed microdroplet production

Crawford, D. F., Smith, C. A. & Whyte, G., 5 Sep 2017, In : Scientific Reports. 7, 10545.

Research output: Contribution to journal › Article

Open Access
File
Pressure
Microfluidics
Lab-On-A-Chip Devices
Growth and Development

Optomechanical measurement of the role of Lamins in whole cell deformability

Kolb, T., Kraxner, J., Skodzek, K., Haug, M., Crawford, D., Maaß, K. K., Aifantis, K. E. & Whyte, G., 9 May 2017, In : Journal of Biophotonics.

Research output: Contribution to journal › Article

Open Access
File
Lamins
Formability
Lamin Type A
cells
mechanical properties

Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions

Lange, J. R., Metzner, C., Richter, S., Schneider, W., Spermann, M., Kolb, T., Whyte, G. & Fabry, B., 11 Apr 2017, In : Biophysical Journal. 112, 7, p. 1472-1480 9 p.

Research output: Contribution to journal › Article

Open Access
File
mechanical measurement
cells
modulus of elasticity
proteins
histograms
2016

High-throughput screening of antibiotic-resistant bacteria in picodroplets

Liu, X., Painter, R. E., Enesa, K., Holmes, D., Whyte, G., Garlisi, C. G., Monsma, F. J., Rehak, M., Craig, F. F. & Smith, C. A., 2016, In : Lab on a Chip. 16, 9, p. 1636-1643 8 p.

Research output: Contribution to journal › Article

Monitoring Early-Stage Nanoparticle Assembly in Microdroplets by Optical Spectroscopy and SERS

Salmon, A. R., Esteban, R., Taylor, R. W., Hugall, J. T., Smith, C. A., Whyte, G., Scherman, O. A., Aizpurua, J., Abell, C. & Baumberg, J. J., 6 Apr 2016, In : Small. 12, 3, p. 1788–1796 9 p.

Research output: Contribution to journal › Article

Open Access
File
Raman Spectrum Analysis
Nanoparticles
Raman spectroscopy
Spectrum Analysis
Nanostructures
2015

A monolithic glass chip for active single-cell sorting based on mechanical phenotyping

Faigle, C., Lautenschlager, F., Whyte, G., Homewood, P., Martin-Badosa, E. & Guck, J., 7 Mar 2015, In : Lab on a Chip. 15, p. 1267-1275

Research output: Contribution to journal › Article

Open Access
File
classifying
chips
glass
mechanical properties
mechanical measurement

Deformation of phospholipid vesicles in an optical stretcher

Delabre, U., Feld, K., Crespo, E., Whyte, G., Sykes, C., Seifert, U. & Guck, J., 14 Aug 2015, In : Soft Matter. 11, 30, p. 6075-6088 14 p.

Research output: Contribution to journal › Article

Phospholipids
traps
mechanical properties
Heating
Mechanical properties

Microconstriction Arrays for High-Throughput Quantitative Measurements of Cell Mechanical Properties

Lange, J. R., Steinwachs, J., Kolb, T., Lautscham, L. A., Harder, I., Whyte, G. & Fabry, B., 2015, In : Biophysical Journal. 109, 1, p. 26-34 9 p.

Research output: Contribution to journal › Article

Open Access
File
Lab-On-A-Chip Devices
Constriction
Elasticity
Suspensions
Pressure
2014

Dynamically reconfigurable fibre optical spanner

Kolb, T., Albert, S., Haug, M. & Whyte, G., Feb 2014, In : Lab on a Chip. 14, p. 1186-1190 5 p.

Research output: Contribution to journal › Article

Open Access
File
optical fibers
interactive control
lab-on-a-chip devices
cells
fiber optics

Dynamic operation of optical fibres beyond the single-mode regime facilitates the orientation of biological cells

Kreysing, M., Ott, D., Schmidberger, M. J., Otto, O., Schürmann, M., Martín-Badosa, E., Whyte, G. & Guck, J., 2014, In : Nature Communications. 5, 5481.

Research output: Contribution to journal › Article

Optical Fibers
Optical fibers
optical fibers
Optical Tweezers
Welding

Impact of heating on passive and active biomechanics of suspended cells

Chan, C. J., Whyte, G., Boyde, L., Salbreux, G. & Guck, J., Apr 2014, In : Interface Focus. 4, 2, p. 2013.0069 1 p.

Research output: Contribution to journal › Article

Biomechanical Phenomena
Heating
TRPV Cation Channels
Temperature
Mechanics

Optofluidic rotation of living cells for single-cell tomography

Kolb, T., Albert, S., Haug, M. & Whyte, G., 2014, In : Journal of Biophotonics.

Research output: Contribution to journal › Article

cytometry
tomography
cells
dimensional analysis
traps

Separation of blood cells with differing deformability using deterministic lateral displacement

Holmes, D., Whyte, G., Bailey, J., Vergara-Irigaray, N., Ekpenyong, A., Guck, J. & Duke, T., 2014, In : Interface Focus. 4, 6, 20140011.

Research output: Contribution to journal › Article

Blood Cells
Equipment and Supplies
Leukocytes
Glutaral
Hydrodynamics
2013

Elastic theory for the deformation of a solid or layered spheroid under axisymmetric loading

Boyde, L., Ekpenyong, A., Whyte, G. & Guck, J., Apr 2013, In : Acta Mechanica. 224, 4, p. 819-839 21 p.

Research output: Contribution to journal › Article

Poisson ratio
Elastic constants
Aspect ratio
Elasticity
Residual stresses
2012

Comparison of stresses on homogeneous spheroids in the optical stretcher computed with geometrical optics and generalized Lorenz-Mie theory

Boyde, L., Ekpenyong, A., Whyte, G. & Guck, J., 20 Nov 2012, In : Applied Optics. 51, 33, p. 7934-7944 11 p.

Research output: Contribution to journal › Article

spheroids
Mie scattering
geometrical optics
cells
hinges

Mechanical environment modulates biological properties of oligodendrocyte progenitor cells.

Jagielska, A., Norman, A. L., Whyte, G., Van Vliet, K. J., Guck, J., Franklin, R. J. M. & Vliet, K. J. V., Nov 2012, In : Stem Cells and Development. 21, 16, p. 2905-2914 10 p.

Research output: Contribution to journal › Article

Oligodendroglia
Stem Cells
Central Nervous System
Biophysics
Nerve Tissue

Validation and perspectives of a femtosecond laser fabricated monolithic optical stretcher

Bellini, N., Bragheri, F., Cristiani, I., Guck, J., Osellame, R. & Whyte, G., 1 Oct 2012, In : Biomedical Optics Express. 3, 10, p. 2658-2668 11 p.

Research output: Contribution to journal › Article

Open Access
File
chips
lasers
glass
leukocytes
cells

Viscoelastic properties of differentiating blood cells are fate- and function-dependent.

Ekpenyong, A. E., Whyte, G., Chalut, K., Pagliara, S., Lautenschläger, F., Fiddler, C., Paschke, S., Keyser, U. F., Chilvers, E. R. & Guck, J., Jan 2012, In : PLoS ONE. 7, 9, p. e45237-e45237

Research output: Contribution to journal › Article

Open Access
File
Blood Cells
Myeloid Cells
Cell Differentiation
Physiological Adaptation
Differentiation Antigens
2010

Generation of picoliter droplets with defined contents and concentration gradients from the separation of chemical mixtures

Theberge, A. B., Whyte, G. & Huck, W. T. S., 2010, In : Analytical Chemistry. 82, 9, p. 3449-3453 5 p.

Research output: Contribution to journal › Article

Microfluidics
Ultraviolet detectors
Liquid chromatography
Titration
Fluorescent Dyes
2009

Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays

Courtois, F., Olguin, L. F., Whyte, G., Theberge, A. B., Huck, W. T. S., Hollfelder, F. & Abell, C., 15 Apr 2009, In : Analytical Chemistry. 81, 8, p. 3008-3016 9 p.

Research output: Contribution to journal › Article

Emulsions
Assays
Molecules
Fluorescein
Bovine Serum Albumin

Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.

Fidalgo, L. M., Whyte, G., Ruotolo, B. T., Benesch, J. L. P., Stengel, F., Abell, C., Robinson, C. V. & Huck, W. T. S., Jan 2009, In : Angewandte Chemie International Edition. 48, 20, p. 3665-3668 4 p.

Research output: Contribution to journal › Article

Microfluidics
Mass spectrometry
Screening
Fluorescence
Proteins

Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments

Shim, J. U., Olguin, L. F., Whyte, G., Scott, D., Babtie, A., Abell, C., Huck, W. T. S. & Hollfelder, F., 28 Oct 2009, In : Journal of the American Chemical Society. 131, 42, p. 15251-15256 6 p.

Research output: Contribution to journal › Article

Phosphatases
Gene expression
Alkaline Phosphatase
Bacteria
Gene Expression

Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays

Huebner, A., Bratton, D., Whyte, G., Yang, M., DeMello, A. J., Abell, C. & Hollfelder, F., 2009, In : Lab on a Chip. 9, 5, p. 692-698

Research output: Contribution to journal › Article

Suzuki-Miyaura coupling reactions in aqueous microdroplets with catalytically active fluorous interfaces

Theberge, A. B., Whyte, G., Frenzel, M., Fidalgo, L. M., Wootton, R. C. R. & Huck, W. T. S., 2009, In : Chemical Communications. 2009, 41, p. 6225-6227 3 p.

Research output: Contribution to journal › Article

Palladium
Microfluidics
Catalysts
Molecules
2008

An integrated device for monitoring time-dependent in vitro expression from single genes in picolitre droplets.

Courtois, F., Olguin, L. F., Whyte, G., Bratton, D., Huck, W. T. S., Abell, C. & Hollfelder, F., 15 Feb 2008, In : ChemBioChem. 9, 3, p. 439-446 8 p.

Research output: Contribution to journal › Article

Lab-On-A-Chip Devices
Green Fluorescent Proteins
Emulsions
Oils
Genotype

Development of Quantitative Cell-Based Enzyme Assays in Microdroplets

Huebner, A., Olguin, L. F., Bratton, D., Whyte, G., Huck, W. T. S., De Mello, A. J., Edel, J. B., Abell, C. & Hollfelder, F., 15 May 2008, In : Analytical Chemistry. 80, 10, p. 3890-3896 7 p.

Research output: Contribution to journal › Article

Dynamic control of higher-order modes in hollow-core photonic crystal fibers

Euser, T. G., Whyte, G., Scharrer, M., Chen, J. S. Y., Abdolvand, A., Nold, J., Kaminski, C. F. & Russell, P. S. J., 27 Oct 2008, In : Optics Express. 16, 22, p. 17972-17981

Research output: Contribution to journal › Article

Open Access
File

From microdroplets to microfluidics: selective emulsion separation in microfluidic devices.

Fidalgo, L. M., Whyte, G., Bratton, D., Kaminski, C. F., Abell, C. & Huck, W. T. S., Jan 2008, In : Angewandte Chemie International Edition. 47, 11, p. 2042-2045 4 p.

Research output: Contribution to journal › Article

Photorealistic visualization of imaging in canonical optical resonators

Nelson, J., Courtial, J. & Whyte, G., Nov 2008, In : American Journal of Physics. 76, 11, p. 991-995 5 p.

Research output: Contribution to journal › Article

optical resonators
resonators
computer programs
ray tracing
fractals

Simulated holographic three-dimensional intensity shaping of evanescent-wave fields

Thomson, L. C., Whyte, G., Mazilu, M. & Courtial, J., 1 May 2008, In : Journal of the Optical Society of America B: Optical Physics. 25, 5, p. 849-853

Research output: Contribution to journal › Article

Simulation of superresolution holography for optical tweezers

Thomson, L. C., Boissel, Y., Whyte, G., Yao, E. & Courtial, J., 13 Feb 2008, In : New Journal of Physics. 10, 023015.

Research output: Contribution to journal › Article

holography
light beams
traps
simulation
diffraction
2007

Optically controlled grippers for manipulating micron-sized particles

Gibson, G., Barron, L., Beck, F., Whyte, G. & Padgett, M., Jan 2007, In : New Journal of Physics. 9, 1, p. 14 1 p.

Research output: Contribution to journal › Article

Open Access
File
traps
manipulators
beads
silicon dioxide
scattering
2006

An optical trapped microhand for manipulating micron-sized objects

Whyte, G., Gibson, G., Leach, J., Padgett, M., Robert, D. & Miles, M., 2006, In : Optics Express. 14, 25, p. 12497-12502 6 p.

Research output: Contribution to journal › Article

beads
manipulators
chromium
traps
silicon dioxide

Iterative algorithms for holographic shaping of non-diffracting and self-imaging light beams

Courtial, J., Whyte, G., Bouchai, Z. & Wagner, J., 1 Jan 2006, In : Optics Express. 14, 6, p. 2108-2116 9 p.

Research output: Contribution to journal › Article

light beams
trapping
diffraction
crystals

Polarization and image rotation induced by a rotating dielectric rod: An optical angular momentum interpretation

Padgett, M., Whyte, G., Girkin, J., Wright, A., Allen, L., Ohberg, P. & Barnett, S. M., 15 Jul 2006, In : Optics Letters. 31, 14, p. 2205-2207 3 p.

Research output: Contribution to journal › Article

Open Access
File
image rotation
rods
angular momentum
polarization
orbitals
2005

Experimental demonstration of holographic three-dimensional light shaping using a Gerchberg-Saxton algorithm

Whyte, G. & Courtial, J., 3 May 2005, In : New Journal of Physics. 7, 1, p. 117

Research output: Contribution to journal › Article

Open Access
File
light beams
2004

Transverse laser modes in Bose-Einstein condensates

Whyte, G., Ohberg, P. & Courtial, J., May 2004, In : Physical Review A. 69, 5, p. 053610 8 p.

Research output: Contribution to journal › Article

Open Access
File
laser modes
Bose-Einstein condensates
lasers
resonators
trapping

Vortex sorter for Bose-Einstein condensates

Whyte, G., Veitch, J., Ohberg, P. & Courtial, J., 1 Jul 2004, In : Physical Review A. 70, 1, 011603.

Research output: Contribution to journal › Article

Open Access
File
classifying
Bose-Einstein condensates
vortices
interferometers