Graeme Whyte

Research output

Research output per year 2004 2006 2008 2009 2012 2013 2014 2016 2017 2020 2022

• 45 Article
• 15 Conference contribution
• 3 Patent
• 1 Paper
• 1 More
  • 1 Meeting abstract

Research output per year

Research output per year

Search results

• 2022

  Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH

  Kermanizadeh, A., Valli, J., Sanchez, K., Hutter, S., Pawlowska, A., Whyte, G., Moritz, W. & Stone, V., Jan 2022, In: Archives of Toxicology. 96, 1, p. 287-303 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Xenobiotic Agent 100%
  • Enalapril Maleate 100%
  • Nanomaterial 75%
  • Liver Disease 75%
  • Diseases 50%
  4 Citations (Scopus)

  12 Downloads (Pure)
• 2020

  Image-Based Single Cell Sorting Automation in Droplet Microfluidics

  Sesen, M. & Whyte, G., 26 May 2020, In: Scientific Reports. 10, 8736.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell 100%
  • Cells 81%
  • Microfluidics 54%
  • Analysis 27%
  • Cell Selection 27%
  46 Citations (Scopus)

  213 Downloads (Pure)

• Purifying stem cell-derived red blood cells: a high-throughput label-free downstream processing strategy based on microfluidic spiral inertial separation and membrane filtration

  Guzniczak, E., Otto, O., Whyte, G., Chandra, T., Robertson, N. A., Willoughby, N., Jimenez, M. & Bridle, H., Jul 2020, In: Biotechnology and Bioengineering. 117, 7, p. 2032-2045 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell 100%
  • Blood 50%
  • Purification 28%
  • Copurification 28%
  • Separation 21%
  8 Citations (Scopus)

  34 Downloads (Pure)
• 2019

  Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

  Kermanizadeh, A., Berthing, T., Guzniczak, E., Wheeldon, M., Whyte, G., Vogel, U., Moritz, W. & Stone, V., 19 Nov 2019, In: Particle and Fibre Toxicology. 16, 42.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nanomaterial 100%
  • Inflammation 33%
  • Adverse Event 16%
  • Cytotoxicity 16%
  • Cytokine 16%
  16 Citations (Scopus)

  27 Downloads (Pure)

• Deformability-induced lift force in spiral microchannels for cell separation

  Guzniczak, E., Otto, O., Whyte, G., Willoughby, N., Jimenez, M. & Bridle, H., 23 Dec 2019, (E-pub ahead of print) In: Lab on a Chip.

  Research output: Contribution to journal › Article › peer-review

  • Formability 100%
  • Microchannel 85%
  • Focusing 42%
  • Microfluidics 28%
  • Fluid Flow 28%
  26 Citations (Scopus)
• 2018

  A comparison of methods to assess cell mechanical properties

  Wu, P. H., Aroush, D. R. B., Asnacios, A., Chen, W. C., Dokukin, M. E., Doss, B. L., Durand-Smet, P., Ekpenyong, A., Guck, J., Guz, N. V., Janmey, P. A., Lee, J. S. H., Moore, N. M., Ott, A., Poh, Y. C., Ros, R., Sander, M., Sokolov, I., Staunton, J. R., Wang, N., & 2 othersWhyte, G. & Wirtz, D., 18 Jun 2018, In: Nature Methods. 15, p. 491-498 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell 100%
  • Probe 42%
  • Strength of Materials 28%
  • Adhesion 28%
  • Cellular Biomechanics 28%
  339 Citations (Scopus)
• 2017

  High-throughput assessment of mechanical properties of stem cell derived red blood cells, toward cellular downstream processing

  Guzniczak, E., Mohammad Zadeh, M., Dempsey, F., Jimenez, M., Bock, H., Whyte, G., Willoughby, N. & Bridle, H., 31 Oct 2017, In: Scientific Reports. 7, 14457.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell 100%
  • Cells 60%
  • Blood 40%
  • Erythrocyte 40%
  • Stem Cell 40%
  17 Citations (Scopus)

  59 Downloads (Pure)

• Image-based closed-loop feedback for highly mono-dispersed microdroplet production

  Crawford, D. F., Smith, C. A. & Whyte, G., 5 Sept 2017, In: Scientific Reports. 7, 10545.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Microfluidics 100%
  • Droplet 66%
  • Pressure 66%
  • Surface Pressure 50%
  • Feedback System 50%
  18 Citations (Scopus)

  61 Downloads (Pure)

• Optomechanical measurement of the role of Lamins in whole cell deformability

  Kolb, T., Kraxner, J., Skodzek, K., Haug, M., Crawford, D., Maaß, K. K., Aifantis, K. E. & Whyte, G., 9 May 2017, (E-pub ahead of print) In: Journal of Biophotonics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Optical Stretcher 100%
  • Lamin 66%
  • Strength of Materials 66%
  • Suspension 33%
  • Nuclear Membrane 33%
  3 Citations (Scopus)

  106 Downloads (Pure)

• Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions

  Lange, J. R., Metzner, C., Richter, S., Schneider, W., Spermann, M., Kolb, T., Whyte, G. & Fabry, B., 11 Apr 2017, In: Biophysical Journal. 112, 7, p. 1472-1480 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Strain 100%
  • Measurement 100%
  • Pressure 100%
  • Modulus of Elasticity 66%
  • Cellular Biomechanics 66%
  34 Citations (Scopus)

  138 Downloads (Pure)
• 2016

  High-throughput screening of antibiotic-resistant bacteria in picodroplets

  Liu, X., Painter, R. E., Enesa, K., Holmes, D., Whyte, G., Garlisi, C. G., Monsma, F. J., Rehak, M., Craig, F. F. & Smith, C. A., 2016, In: Lab on a Chip. 16, 9, p. 1636-1643 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Antibiotic-Resistant Bacteria 100%
  • Escherichia coli 50%
  • Methicillin-Resistant Staphylococcus Aureus 50%
  • Prevalence 50%
  • High-Throughput Screening 50%
  76 Citations (Scopus)

• Monitoring Early-Stage Nanoparticle Assembly in Microdroplets by Optical Spectroscopy and SERS

  Salmon, A. R., Esteban, R., Taylor, R. W., Hugall, J. T., Smith, C. A., Whyte, G., Scherman, O. A., Aizpurua, J., Abell, C. & Baumberg, J. J., 6 Apr 2016, In: Small. 12, 3, p. 1788–1796 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nanoparticle 100%
  • Surface Enhanced Raman Spectroscopy 50%
  • Assembly 50%
  • Microfluidics 50%
  • Surface-Enhanced Raman Spectroscopy 50%
  27 Citations (Scopus)

  64 Downloads (Pure)
• 2015

  A monolithic glass chip for active single-cell sorting based on mechanical phenotyping

  Faigle, C., Lautenschlager, F., Whyte, G., Homewood, P., Martin-Badosa, E. & Guck, J., 7 Mar 2015, In: Lab on a Chip. 15, p. 1267-1275

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glass 100%
  • Populations 75%
  • Strength of Materials 50%
  • Fluorescence 50%
  • Detection 50%
  29 Citations (Scopus)

  433 Downloads (Pure)

• Deformation of phospholipid vesicles in an optical stretcher

  Delabre, U., Feld, K., Crespo, E., Whyte, G., Sykes, C., Seifert, U. & Guck, J., 14 Aug 2015, In: Soft Matter. 11, 30, p. 6075-6088 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Vesicle 100%
  • Deformation 85%
  • Phospholipid 57%
  • Phospholipid Vesicle 57%
  • Model 42%
  38 Citations (Scopus)

• Microconstriction Arrays for High-Throughput Quantitative Measurements of Cell Mechanical Properties

  Lange, J. R., Steinwachs, J., Kolb, T., Lautscham, L. A., Harder, I., Whyte, G. & Fabry, B., 2015, In: Biophysical Journal. 109, 1, p. 26-34 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Constriction 100%
  • Devices 50%
  • Ligation 50%
  • Mechanical Properties 50%
  • Strength of Materials 50%
  99 Citations (Scopus)

  242 Downloads (Pure)
• 2014

  Dynamically reconfigurable fibre optical spanner

  Kolb, T., Albert, S., Haug, M. & Whyte, G., Feb 2014, In: Lab on a Chip. 14, p. 1186-1190 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell 100%
  • Rotation 75%
  • Optical Power 50%
  • Microfluidics 50%
  • Confocal Microscopy 50%
  22 Citations (Scopus)

  391 Downloads (Pure)

• Dynamic operation of optical fibres beyond the single-mode regime facilitates the orientation of biological cells

  Kreysing, M., Ott, D., Schmidberger, M. J., Otto, O., Schürmann, M., Martín-Badosa, E., Whyte, G. & Guck, J., 2014, In: Nature Communications. 5, 5481.

  Research output: Contribution to journal › Article › peer-review

  • Optical Fiber 100%
  • Deterioration 66%
  • Information 66%
  • Output 66%
  • Electromagnetism 33%
  51 Citations (Scopus)

• Impact of heating on passive and active biomechanics of suspended cells

  Chan, C. J., Whyte, G., Boyde, L., Salbreux, G. & Guck, J., Apr 2014, In: Interface Focus. 4, 2, p. 2013.0069 1 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell 100%
  • Cellular Biomechanics 50%
  • Probe 50%
  • Responses 37%
  • Heating 37%
  34 Citations (Scopus)

• Optofluidic rotation of living cells for single-cell tomography

  Kolb, T., Albert, S., Haug, M. & Whyte, G., 2014, In: Journal of Biophotonics.

  Research output: Contribution to journal › Article › peer-review

  • Flow 100%
  • Cytometry 66%
  • Structure 66%
  • Procedure 66%
  • Rotation 66%
  30 Citations (Scopus)

• Separation of blood cells with differing deformability using deterministic lateral displacement

  Holmes, D., Whyte, G., Bailey, J., Vergara-Irigaray, N., Ekpenyong, A., Guck, J. & Duke, T., 2014, In: Interface Focus. 4, 6, 20140011.

  Research output: Contribution to journal › Article › peer-review

  • Cells 100%
  • Lateral Displacement 66%
  • Devices 55%
  • Rigidity 44%
  • Leucocyte 33%
  87 Citations (Scopus)
• 2013

  Elastic theory for the deformation of a solid or layered spheroid under axisymmetric loading

  Boyde, L., Ekpenyong, A., Whyte, G. & Guck, J., Apr 2013, In: Acta Mechanica. 224, 4, p. 819-839 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Deformation 100%
  • Spheroid 80%
  • Surfaces 60%
  • Elasticity 40%
  • Poisson Ratio 40%
  6 Citations (Scopus)
• 2012

  Comparison of stresses on homogeneous spheroids in the optical stretcher computed with geometrical optics and generalized Lorenz-Mie theory

  Boyde, L., Ekpenyong, A., Whyte, G. & Guck, J., 20 Nov 2012, In: Applied Optics. 51, 33, p. 7934-7944 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Geometrical Optics 100%
  • Stretcher 100%
  • Mie Scattering 100%
  • Wavelength 66%
  • Spheroid 66%
  19 Citations (Scopus)

• Mechanical environment modulates biological properties of oligodendrocyte progenitor cells.

  Jagielska, A., Norman, A. L., Whyte, G., Van Vliet, K. J., Guck, J., Franklin, R. J. M. & Vliet, K. J. V., Nov 2012, In: Stem Cells and Development. 21, 16, p. 2905-2914 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligodendrocyte Progenitor 100%
  • Central Nervous System 42%
  • In Vitro 28%
  • Cellular Differentiation 28%
  • Myelinogenesis 28%
  85 Citations (Scopus)

• Validation and perspectives of a femtosecond laser fabricated monolithic optical stretcher

  Bellini, N., Bragheri, F., Cristiani, I., Guck, J., Osellame, R. & Whyte, G., 1 Oct 2012, In: Biomedical Optics Express. 3, 10, p. 2658-2668 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Microfluidics 100%
  • Glass 50%
  • Potential 33%
  • Laser Pulse 33%
  • Application 16%
  42 Citations (Scopus)

  74 Downloads (Pure)

• Viscoelastic properties of differentiating blood cells are fate- and function-dependent.

  Ekpenyong, A. E., Whyte, G., Chalut, K., Pagliara, S., Lautenschläger, F., Fiddler, C., Paschke, S., Keyser, U. F., Chilvers, E. R. & Guck, J., Jan 2012, In: PLoS ONE. 7, 9, p. e45237-e45237

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cells 100%
  • Cell Differentiation 40%
  • Myeloid 40%
  • Cellular Differentiation 40%
  • Lineages 20%
  140 Citations (Scopus)

  124 Downloads (Pure)
• 2010

  Generation of picoliter droplets with defined contents and concentration gradients from the separation of chemical mixtures

  Theberge, A. B., Whyte, G. & Huck, W. T. S., 2010, In: Analytical Chemistry. 82, 9, p. 3449-3453 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Droplet 100%
  • Concentration 44%
  • Procedure 44%
  • Microfluidics 44%
  • Application 33%
  42 Citations (Scopus)
• 2009

  Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays

  Courtois, F., Olguin, L. F., Whyte, G., Theberge, A. B., Huck, W. T. S., Hollfelder, F. & Abell, C., 15 Apr 2009, In: Analytical Chemistry. 81, 8, p. 3008-3016 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Fluorescein 100%
  • Bovine Serum Albumin 75%
  • Emulsion 50%
  • Experiment 50%
  • Enzyme Activity 25%
  169 Citations (Scopus)

• Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.

  Fidalgo, L. M., Whyte, G., Ruotolo, B. T., Benesch, J. L. P., Stengel, F., Abell, C., Robinson, C. V. & Huck, W. T. S., Jan 2009, In: Angewandte Chemie International Edition. 48, 20, p. 3665-3668 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Mass Spectrometry 100%
  • Screening 50%
  • Synthesis 50%
  • Fluorescence 50%
  • Evolution 50%
  151 Citations (Scopus)

• Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments

  Shim, J. U., Olguin, L. F., Whyte, G., Scott, D., Babtie, A., Abell, C., Huck, W. T. S. & Hollfelder, F., 28 Oct 2009, In: Journal of the American Chemical Society. 131, 42, p. 15251-15256 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Enzyme Activity 100%
  • Bacterium 66%
  • Gene Expression 66%
  • Alkaline Phosphatase 66%
  • Fluorescence 33%
  142 Citations (Scopus)

• Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays

  Huebner, A., Bratton, D., Whyte, G., Yang, M., DeMello, A. J., Abell, C. & Hollfelder, F., 2009, In: Lab on a Chip. 9, 5, p. 692-698

  Research output: Contribution to journal › Article › peer-review
  285 Citations (Scopus)

• Suzuki-Miyaura coupling reactions in aqueous microdroplets with catalytically active fluorous interfaces

  Theberge, A. B., Whyte, G., Frenzel, M., Fidalgo, L. M., Wootton, R. C. R. & Huck, W. T. S., 2009, In: Chemical Communications. 2009, 41, p. 6225-6227 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Procedure 100%
  • Synthesis (Chemical) 100%
  • Molecule 100%
  • Reactor 100%
  • Microfluidics 100%
  63 Citations (Scopus)
• 2008

  An integrated device for monitoring time-dependent in vitro expression from single genes in picolitre droplets.

  Courtois, F., Olguin, L. F., Whyte, G., Bratton, D., Huck, W. T. S., Abell, C. & Hollfelder, F., 15 Feb 2008, In: ChemBioChem. 9, 3, p. 439-446 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Nested Gene 100%
  • Emulsion 100%
  • Phenotype 100%
  • Screening 100%
  • Green Fluorescent Protein 100%
  160 Citations (Scopus)

• Development of Quantitative Cell-Based Enzyme Assays in Microdroplets

  Huebner, A., Olguin, L. F., Bratton, D., Whyte, G., Huck, W. T. S., De Mello, A. J., Edel, J. B., Abell, C. & Hollfelder, F., 15 May 2008, In: Analytical Chemistry. 80, 10, p. 3890-3896 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Kinetics 100%
  • Lysozyme 100%
  • Development 100%
  • Enzyme Assay 100%
  • Time 100%
  181 Citations (Scopus)

• Dynamic control of higher-order modes in hollow-core photonic crystal fibers

  Euser, T. G., Whyte, G., Scharrer, M., Chen, J. S. Y., Abdolvand, A., Nold, J., Kaminski, C. F. & Russell, P. S. J., 27 Oct 2008, In: Optics Express. 16, 22, p. 17972-17981

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  70 Citations (Scopus)

  353 Downloads (Pure)

• From microdroplets to microfluidics: selective emulsion separation in microfluidic devices.

  Fidalgo, L. M., Whyte, G., Bratton, D., Kaminski, C. F., Abell, C. & Huck, W. T. S., Jan 2008, In: Angewandte Chemie International Edition. 47, 11, p. 2042-2045 4 p.

  Research output: Contribution to journal › Article › peer-review
  139 Citations (Scopus)

• Photorealistic visualization of imaging in canonical optical resonators

  Nelson, J., Courtial, J. & Whyte, G., Nov 2008, In: American Journal of Physics. 76, 11, p. 991-995 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Resonator 100%
  • Optical Resonator 66%
  • Ray Tracing 33%
  • Light 33%
  5 Citations (Scopus)

• Simulated holographic three-dimensional intensity shaping of evanescent-wave fields

  Thomson, L. C., Whyte, G., Mazilu, M. & Courtial, J., 1 May 2008, In: Journal of the Optical Society of America B: Optical Physics. 25, 5, p. 849-853

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Simulation of superresolution holography for optical tweezers

  Thomson, L. C., Boissel, Y., Whyte, G., Yao, E. & Courtial, J., 13 Feb 2008, In: New Journal of Physics. 10, 023015.

  Research output: Contribution to journal › Article › peer-review

  • Optical Tweezer 100%
  • Algorithms 75%
  • Holography 50%
  • Light Beams 50%
  • Diffraction 50%
  15 Citations (Scopus)
• 2007

  Optically controlled grippers for manipulating micron-sized particles

  Gibson, G., Barron, L., Beck, F., Whyte, G. & Padgett, M., Jan 2007, In: New Journal of Physics. 9, 1, p. 14 1 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Manipulator 100%
  • Trap 75%
  • Grippers 75%
  • Micron 75%
  • Silicon Dioxide 25%
  20 Citations (Scopus)

  408 Downloads (Pure)
• 2006

  An optical trapped microhand for manipulating micron-sized objects

  Whyte, G., Gibson, G., Leach, J., Padgett, M., Robert, D. & Miles, M., 2006, In: Optics Express. 14, 25, p. 12497-12502 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Time 100%
  • Silica 50%
  • Silicon Dioxide 50%
  • Chromium 50%
  • Scattering 50%
  57 Citations (Scopus)

• Iterative algorithms for holographic shaping of non-diffracting and self-imaging light beams

  Courtial, J., Whyte, G., Bouchai, Z. & Wagner, J., 1 Jan 2006, In: Optics Express. 14, 6, p. 2108-2116 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Light Beams 100%
  • Algorithms 100%
  • Light 50%
  • Utilization 50%
  • Calculation 50%
  28 Citations (Scopus)

• Polarization and image rotation induced by a rotating dielectric rod: An optical angular momentum interpretation

  Padgett, M., Whyte, G., Girkin, J., Wright, A., Allen, L., Ohberg, P. & Barnett, S. M., 15 Jul 2006, In: Optics Letters. 31, 14, p. 2205-2207 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Rotation 100%
  • Light 75%
  • Angular Momentum 50%
  • Images 50%
  • Polarization 50%
  50 Citations (Scopus)

  219 Downloads (Pure)
• 2005

  Experimental demonstration of holographic three-dimensional light shaping using a Gerchberg-Saxton algorithm

  Whyte, G. & Courtial, J., 3 May 2005, In: New Journal of Physics. 7, 1, p. 117

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Light Beams 100%
  • Algorithms 66%
  • Representation 66%
  • Proving 33%
  • Luminaires 33%
  102 Citations (Scopus)

  76 Downloads (Pure)
• 2004

  Transverse laser modes in Bose-Einstein condensates

  Whyte, G., Ohberg, P. & Courtial, J., May 2004, In: Physical Review A. 69, 5, p. 053610 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Bose-Einstein Condensates 100%
  • Light 42%
  • Laser 42%
  • Laser Modes 28%
  • Resonator 14%
  11 Citations (Scopus)

  49 Downloads (Pure)

• Vortex sorter for Bose-Einstein condensates

  Whyte, G., Veitch, J., Ohberg, P. & Courtial, J., 1 Jul 2004, In: Physical Review A. 70, 1, 011603.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Eddy 100%
  • Bose-Einstein Condensates 66%
  • Rotation 66%
  • Interferometer 33%
  • Value 33%
  4 Citations (Scopus)

  285 Downloads (Pure)