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Research Output

2020

Image-Based Single Cell Sorting Automation in Droplet Microfluidics

Sesen, M. & Whyte, G., 26 May 2020, In : Scientific Reports. 10, 8736.

Research output: Contribution to journalArticle

Open Access
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1 Downloads (Pure)

Purifying stem cell-derived red blood cells: a high-throughput label-free downstream processing strategy based on microfluidic spiral inertial separation and membrane filtration

Guzniczak, E., Otto, O., Whyte, G., Chandra, T., Robertson, N. A., Willoughby, N., Jimenez, M. & Bridle, H., Jul 2020, In : Biotechnology and Bioengineering. 117, 7, p. 2032-2045 14 p.

Research output: Contribution to journalArticle

2019

Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

Kermanizadeh, A., Berthing, T., Guzniczak, E., Wheeldon, M., Whyte, G., Vogel, U., Moritz, W. & Stone, V., 19 Nov 2019, In : Particle and Fibre Toxicology. 16, 42.

Research output: Contribution to journalArticle

Open Access
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7 Downloads (Pure)

Deformability-induced lift force in spiral microchannels for cell separation

Guzniczak, E., Otto, O., Whyte, G., Willoughby, N., Jimenez, M. & Bridle, H., 23 Dec 2019, In : Lab on a Chip.

Research output: Contribution to journalArticle

Microfluidic devices and systems

Smith, C. A., Xin, L., Enesa, K., Liu, X., Craig, F. F. & Whyte, G., 2 Apr 2019, Patent No. 10,247,655, 30 Jul 2014

Research output: Patent

2018

A comparison of methods to assess cell mechanical properties

Wu, P. H., Aroush, D. R. B., Asnacios, A., Chen, W. C., Dokukin, M. E., Doss, B. L., Durand-Smet, P., Ekpenyong, A., Guck, J., Guz, N. V., Janmey, P. A., Lee, J. S. H., Moore, N. M., Ott, A., Poh, Y. C., Ros, R., Sander, M., Sokolov, I., Staunton, J. R., Wang, N. & 2 others, Whyte, G. & Wirtz, D., 18 Jun 2018, In : Nature Methods. 15, p. 491-498 8 p.

Research output: Contribution to journalArticle

Open Access
2017

High-throughput assessment of mechanical properties of stem cell derived red blood cells, toward cellular downstream processing

Guzniczak, E., Mohammad Zadeh, M., Dempsey, F., Jimenez, M., Bock, H., Whyte, G., Willoughby, N. & Bridle, H., 31 Oct 2017, In : Scientific Reports. 7, 14457.

Research output: Contribution to journalArticle

Open Access
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20 Downloads (Pure)

Image-based closed-loop feedback for highly mono-dispersed microdroplet production

Crawford, D. F., Smith, C. A. & Whyte, G., 5 Sep 2017, In : Scientific Reports. 7, 10545.

Research output: Contribution to journalArticle

Open Access
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29 Downloads (Pure)

Optomechanical measurement of the role of Lamins in whole cell deformability

Kolb, T., Kraxner, J., Skodzek, K., Haug, M., Crawford, D., Maaß, K. K., Aifantis, K. E. & Whyte, G., 9 May 2017, In : Journal of Biophotonics.

Research output: Contribution to journalArticle

Open Access
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51 Downloads (Pure)

Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions

Lange, J. R., Metzner, C., Richter, S., Schneider, W., Spermann, M., Kolb, T., Whyte, G. & Fabry, B., 11 Apr 2017, In : Biophysical Journal. 112, 7, p. 1472-1480 9 p.

Research output: Contribution to journalArticle

Open Access
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50 Downloads (Pure)
2016

Cell Mechanical Properties Measured with Micron-Scale Constrictions: Influence of Pressure, Strain and Culture Conditions

Lange, J. R., Steinwachs, J., Metzner, C., Whyte, G. & Fabry, B., 16 Feb 2016, In : Biophysical Journal. 110, 3, Suppl. 1, p. 135a 1 p.

Research output: Contribution to journalMeeting abstract

High-throughput screening of antibiotic-resistant bacteria in picodroplets

Liu, X., Painter, R. E., Enesa, K., Holmes, D., Whyte, G., Garlisi, C. G., Monsma, F. J., Rehak, M., Craig, F. F. & Smith, C. A., 2016, In : Lab on a Chip. 16, 9, p. 1636-1643 8 p.

Research output: Contribution to journalArticle

Microfluidic systems

Joaquim, T. R., Stafford, L. J., Chambers, R. S., Liu, X., Smith, C. A., Li, X. & Whyte, G., 23 Feb 2016, Patent No. US9267918 B2

Research output: Patent

Monitoring Early-Stage Nanoparticle Assembly in Microdroplets by Optical Spectroscopy and SERS

Salmon, A. R., Esteban, R., Taylor, R. W., Hugall, J. T., Smith, C. A., Whyte, G., Scherman, O. A., Aizpurua, J., Abell, C. & Baumberg, J. J., 6 Apr 2016, In : Small. 12, 3, p. 1788–1796 9 p.

Research output: Contribution to journalArticle

Open Access
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41 Downloads (Pure)
2015

A monolithic glass chip for active single-cell sorting based on mechanical phenotyping

Faigle, C., Lautenschlager, F., Whyte, G., Homewood, P., Martin-Badosa, E. & Guck, J., 7 Mar 2015, In : Lab on a Chip. 15, p. 1267-1275

Research output: Contribution to journalArticle

Open Access
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299 Downloads (Pure)

Deformation of phospholipid vesicles in an optical stretcher

Delabre, U., Feld, K., Crespo, E., Whyte, G., Sykes, C., Seifert, U. & Guck, J., 14 Aug 2015, In : Soft Matter. 11, 30, p. 6075-6088 14 p.

Research output: Contribution to journalArticle

Microconstriction Arrays for High-Throughput Quantitative Measurements of Cell Mechanical Properties

Lange, J. R., Steinwachs, J., Kolb, T., Lautscham, L. A., Harder, I., Whyte, G. & Fabry, B., 2015, In : Biophysical Journal. 109, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

Open Access
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162 Downloads (Pure)
2014

Dynamically reconfigurable fibre optical spanner

Kolb, T., Albert, S., Haug, M. & Whyte, G., Feb 2014, In : Lab on a Chip. 14, p. 1186-1190 5 p.

Research output: Contribution to journalArticle

Open Access
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291 Downloads (Pure)

Dynamic operation of optical fibres beyond the single-mode regime facilitates the orientation of biological cells

Kreysing, M., Ott, D., Schmidberger, M. J., Otto, O., Schürmann, M., Martín-Badosa, E., Whyte, G. & Guck, J., 2014, In : Nature Communications. 5, 5481.

Research output: Contribution to journalArticle

Impact of heating on passive and active biomechanics of suspended cells

Chan, C. J., Whyte, G., Boyde, L., Salbreux, G. & Guck, J., Apr 2014, In : Interface Focus. 4, 2, p. 2013.0069 1 p.

Research output: Contribution to journalArticle

Microfluidic systems

Abell, C., Huck, W. T. S., Bratton, D., Whyte, G. & Fidalgo, L. M., 9 Sep 2014, Patent No. US8828210 B2

Research output: Patent

Optofluidic rotation of living cells for single-cell tomography

Kolb, T., Albert, S., Haug, M. & Whyte, G., 2014, In : Journal of Biophotonics.

Research output: Contribution to journalArticle

Separation of blood cells with differing deformability using deterministic lateral displacement

Holmes, D., Whyte, G., Bailey, J., Vergara-Irigaray, N., Ekpenyong, A., Guck, J. & Duke, T., 2014, In : Interface Focus. 4, 6, 20140011.

Research output: Contribution to journalArticle

2013

Elastic theory for the deformation of a solid or layered spheroid under axisymmetric loading

Boyde, L., Ekpenyong, A., Whyte, G. & Guck, J., Apr 2013, In : Acta Mechanica. 224, 4, p. 819-839 21 p.

Research output: Contribution to journalArticle

Fashioning microscopic tools

Phillips, D. B., Whyte, G., Carberry, D. M., Hanna, S., Miles, M. J., Padgett, M. J. & Simpson, S. H., 2013, Optical Trapping and Optical Micromanipulation X. Dholakia, K. & Spalding, G. C. (eds.). Vol. 8810. 881029. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 8810).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

High-resolution imaging of the nuclear envelope for investigation of the mechanical influence of the nucleus on cellular mechanics

Kolb, T. & Whyte, G., 2013, Optical Trapping Applications, OTA 2013.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

High-resolution imaging of the nuclear envelope for investigation of the mechanical influence of the nucleus on cellular mechanics

Kolb, T. & Whyte, G., 2013, Optical Molecular Probes, Imaging and Drug Delivery 2013. Optical Society of America, JT2A.33

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rotation of Optically Trapped Living Cells for Single-Cell Tomography

Kolb, T. & Whyte, G., 2013, Optical Trapping Applications, OTA 2013. p. TM4D.4

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2012

Comparison of stresses on homogeneous spheroids in the optical stretcher computed with geometrical optics and generalized Lorenz-Mie theory

Boyde, L., Ekpenyong, A., Whyte, G. & Guck, J., 20 Nov 2012, In : Applied Optics. 51, 33, p. 7934-7944 11 p.

Research output: Contribution to journalArticle

Femtosecond laser fabricated monolithic devices for single cell manipulation

Bragheri, F., Minzioni, P., Vazquez, R. M., Bellini, N., Paiè, P., Mondello, C., Ramponi, R., Whyte, G., Cristiani, I., Guck, J. & Osellame, R., 2012, Frontiers in Optics 2012. Optical Society of America

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mechanical environment modulates biological properties of oligodendrocyte progenitor cells.

Jagielska, A., Norman, A. L., Whyte, G., Van Vliet, K. J., Guck, J., Franklin, R. J. M. & Vliet, K. J. V., Nov 2012, In : Stem Cells and Development. 21, 16, p. 2905-2914 10 p.

Research output: Contribution to journalArticle

Validation and perspectives of a femtosecond laser fabricated monolithic optical stretcher

Bellini, N., Bragheri, F., Cristiani, I., Guck, J., Osellame, R. & Whyte, G., 1 Oct 2012, In : Biomedical Optics Express. 3, 10, p. 2658-2668 11 p.

Research output: Contribution to journalArticle

Open Access
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Viscoelastic properties of differentiating blood cells are fate- and function-dependent.

Ekpenyong, A. E., Whyte, G., Chalut, K., Pagliara, S., Lautenschläger, F., Fiddler, C., Paschke, S., Keyser, U. F., Chilvers, E. R. & Guck, J., Jan 2012, In : PLoS ONE. 7, 9, p. e45237-e45237

Research output: Contribution to journalArticle

Open Access
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110 Downloads (Pure)
2010

Dual-beam laser traps in biology and medicine: When one beam is not enough

Whyte, G., Lautenschläger, F., Kreysing, M., Boyde, L., Ekpenyong, A., Delabre, U., Chalut, K., Franze, K. & Guck, J., 27 Aug 2010, Optical Trapping and Optical Micromanipulation VII. SPIE, 77620G. (Proceedings of SPIE; vol. 7762).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Generation of picoliter droplets with defined contents and concentration gradients from the separation of chemical mixtures

Theberge, A. B., Whyte, G. & Huck, W. T. S., 2010, In : Analytical Chemistry. 82, 9, p. 3449-3453 5 p.

Research output: Contribution to journalArticle

2009

Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays

Courtois, F., Olguin, L. F., Whyte, G., Theberge, A. B., Huck, W. T. S., Hollfelder, F. & Abell, C., 15 Apr 2009, In : Analytical Chemistry. 81, 8, p. 3008-3016 9 p.

Research output: Contribution to journalArticle

Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.

Fidalgo, L. M., Whyte, G., Ruotolo, B. T., Benesch, J. L. P., Stengel, F., Abell, C., Robinson, C. V. & Huck, W. T. S., Jan 2009, In : Angewandte Chemie International Edition. 48, 20, p. 3665-3668 4 p.

Research output: Contribution to journalArticle

Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments

Shim, J. U., Olguin, L. F., Whyte, G., Scott, D., Babtie, A., Abell, C., Huck, W. T. S. & Hollfelder, F., 28 Oct 2009, In : Journal of the American Chemical Society. 131, 42, p. 15251-15256 6 p.

Research output: Contribution to journalArticle

Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays

Huebner, A., Bratton, D., Whyte, G., Yang, M., DeMello, A. J., Abell, C. & Hollfelder, F., 2009, In : Lab on a Chip. 9, 5, p. 692-698

Research output: Contribution to journalArticle

Suzuki-Miyaura coupling reactions in aqueous microdroplets with catalytically active fluorous interfaces

Theberge, A. B., Whyte, G., Frenzel, M., Fidalgo, L. M., Wootton, R. C. R. & Huck, W. T. S., 2009, In : Chemical Communications. 2009, 41, p. 6225-6227 3 p.

Research output: Contribution to journalArticle

2008

An integrated device for monitoring time-dependent in vitro expression from single genes in picolitre droplets.

Courtois, F., Olguin, L. F., Whyte, G., Bratton, D., Huck, W. T. S., Abell, C. & Hollfelder, F., 15 Feb 2008, In : ChemBioChem. 9, 3, p. 439-446 8 p.

Research output: Contribution to journalArticle

Development of Quantitative Cell-Based Enzyme Assays in Microdroplets

Huebner, A., Olguin, L. F., Bratton, D., Whyte, G., Huck, W. T. S., De Mello, A. J., Edel, J. B., Abell, C. & Hollfelder, F., 15 May 2008, In : Analytical Chemistry. 80, 10, p. 3890-3896 7 p.

Research output: Contribution to journalArticle

Dynamic control of higher-order modes in hollow-core photonic crystal fibers

Euser, T. G., Whyte, G., Scharrer, M., Chen, J. S. Y., Abdolvand, A., Nold, J., Kaminski, C. F. & Russell, P. S. J., 27 Oct 2008, In : Optics Express. 16, 22, p. 17972-17981

Research output: Contribution to journalArticle

Open Access
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217 Downloads (Pure)

From microdroplets to microfluidics: selective emulsion separation in microfluidic devices.

Fidalgo, L. M., Whyte, G., Bratton, D., Kaminski, C. F., Abell, C. & Huck, W. T. S., Jan 2008, In : Angewandte Chemie International Edition. 47, 11, p. 2042-2045 4 p.

Research output: Contribution to journalArticle

Kinetics of protein expression in single cells using microfluidics

Shim, J. U., Olguin, L., Whyte, G., Bratton, D., Hollfelder, F., Abell, C. & Huck, W., 2008, p. 1940-1942. 3 p.

Research output: Contribution to conferencePaper

Photorealistic visualization of imaging in canonical optical resonators

Nelson, J., Courtial, J. & Whyte, G., Nov 2008, In : American Journal of Physics. 76, 11, p. 991-995 5 p.

Research output: Contribution to journalArticle

Simulated holographic three-dimensional intensity shaping of evanescent-wave fields

Thomson, L. C., Whyte, G., Mazilu, M. & Courtial, J., 1 May 2008, In : Journal of the Optical Society of America B: Optical Physics. 25, 5, p. 849-853

Research output: Contribution to journalArticle

Simulation of superresolution holography for optical tweezers

Thomson, L. C., Boissel, Y., Whyte, G., Yao, E. & Courtial, J., 13 Feb 2008, In : New Journal of Physics. 10, 023015.

Research output: Contribution to journalArticle

2007

New holographic 3D light shaping

Thomson, L., Whyte, G., Mazilu, M. & Courtial, J., 2007, Frontiers in Optics 2007. Optical Society of America

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Optically controlled grippers for manipulating micron-sized particles

Gibson, G., Barron, L., Beck, F., Whyte, G. & Padgett, M., Jan 2007, In : New Journal of Physics. 9, 1, p. 14 1 p.

Research output: Contribution to journalArticle

Open Access
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396 Downloads (Pure)