20102020

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2020

Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators

Wang, P., Luchowska-Stańska, U., Van Basten, B., Chen, H., Liu, Z., Wiejak, J., Whelan, P., Morgan, D., Lochhead, E., Barker, G., Rehmann, H., Yarwood, S. J. & Zhou, J., 28 May 2020, In : Journal of Medicinal Chemistry. 63, 10, p. 5159–5184 26 p.

Research output: Contribution to journalArticle

2019

Batch Versus Flow Lithiation-Substitution of 1,3,4-Oxadiazoles: Exploitation of Unstable Intermediates Using Flow Chemistry

Wong, J. Y. F., Tobin, J. M., Vilela, F. & Barker, G., 20 Sep 2019, In : Chemistry - A European Journal. 25, 53, p. 12439-12445 7 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)

Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1

Beck, E. M., Parnell, E., Cowley, A., Porter, A., Gillespie, J., Robinson, J., Robinson, L., Pannifer, A. D., Hamon, V., Jones, P., Morrison, A., McElroy, S., Timmerman, M., Rutjes, H., Mahajan, P., Wiejak, J., Luchowska-Stańska, U., Morgan, D., Barker, G., Rehmann, H. & 1 others, Yarwood, S. J., 12 Nov 2019, In : Cells. 8, 11, 1425.

Research output: Contribution to journalArticle

Open Access
File
5 Downloads (Pure)

Lithiation Substitution of Unprotected Benzyltetrazoles

Wong, J. Y. F., Lewandowska, A., Trowse, B. & Barker, G., 6 Sep 2019, In : Organic Letters. 21, 17, p. 7069-7072 4 p.

Research output: Contribution to journalArticle

Selective small-molecule EPAC activators

Luchowska-Stańska, U., Morgan, D., Yarwood, S. J. & Barker, G., 11 Oct 2019, In : Biochemical Society Transactions. 47, 5, p. 1415-1427 13 p.

Research output: Contribution to journalArticle

Open Access
File
34 Downloads (Pure)
2017

Metalation-Substitution of an α-Oxygenated Chrial Nitrile

Alshawish, M., Barker, G., Measom, N. D. & Coldham, I., Jun 2017, In : Comptes Rendus Chimie. 20, 6, p. 601-608 8 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
12 Downloads (Pure)
2015
Open Access
File
14 Citations (Scopus)
40 Downloads (Pure)

Dehydrative Thiolation of Allenols: Indium vs Gold Catalysis

Webster, S., Young, P. C., Barker, G., Rosair, G. M. & Lee, A-L., 2015, In : Journal of Organic Chemistry. 80, p. 1703-1708

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
42 Downloads (Pure)

Gold-Catalyzed Proto- and Deuterodeboronation

Barker, G., Webster, S., Johnson, D. G., Curley, R., Andrews, M., Young, P. C., Macgregor, S. A. & Lee, A-L., 16 Oct 2015, In : Journal of Organic Chemistry. 80, 20, p. 9807-9816 10 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
123 Downloads (Pure)

Indium Versus Gold Catalysis in Dehydrative Reactions with Allylic Alcohols

Webster, S., Schaefer, L., Barker, G. & Lee, A-L., 2 Oct 2015, In : SYNLETT. 26, 19, p. 2673-2678 6 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
19 Downloads (Pure)
2014

Formation of Unexpected Heterocyclic Products from Pyrolysis of Thiocarbonyl Stabilised Phosphonium Ylides

Aitken, R. A., Barker, G., Cleghorn, L. P., Reid, E. J. & Roberts, S. S., 2014, In : Heterocycles. 88, 2, p. 1135-1147

Research output: Contribution to journalArticle

3 Citations (Scopus)

Gold(I)-Catalysed Direct Thioetherifications Using Allylic Alcohols: an Experimental and Computational Study

Herkert, L., Green, S. L. J., Barker, G., Johnson, D. G., Young, P. C., Macgregor, S. A. & Lee, A., 1 Sep 2014, In : Chemistry - A European Journal. 20, 36, p. 11540-11548

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
108 Downloads (Pure)
2013

Asymmetric Lithiation Trapping of N-Boc Heterocycles at Temperatures above −78 °C

Gelardi, G., Barker, G., O'Brien, P. & Blakemore, D. C., 1 Nov 2013, In : Organic Letters. 15, 21, p. 5424-5427 4 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Gold(I)-catalysed one-pot synthesis of chromans using allylic alcohols and phenols

Coutant, E., Young, P. C., Barker, G. & Lee, A-L., 4 Sep 2013, In : Beilstein Journal of Organic Chemistry. 9, p. 1797-1806 10 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
66 Downloads (Pure)

Remarkable Configurational Stability of Magnesiated Nitriles

Barker, G., Alshawish, M. R., Skilbeck, M. C. & Coldham, I., 22 Jul 2013, In : Angewandte Chemie International Edition. 52, 30, p. 7700-7703

Research output: Contribution to journalArticle

18 Citations (Scopus)
2012

An Experimental and in Situ IR Spectroscopic Study of the Lithiation–Substitution of N-Boc-2-phenylpyrrolidine and -piperidine: Controlling the Formation of Quaternary Stereocenters

Sheikh, N. S., Leonori, D., Barker, G., Firth, J. D., Campos, K. R., Meijer, A. J. H. M., O'Brien, P. & Coldham, I., 21 Mar 2012, In : Journal of the American Chemical Society. 134, 11, p. 5300-5308 9 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)
2011

Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc Pyrrolidine: In Situ React IR Spectroscopic Monitoring, Scope, and Synthetic Applications

Barker, G., McGrath, J. L., Klapars, A., Stead, D., Zhou, G., Campos, K. R. & O'Brien, P., 5 Aug 2011, In : Journal of Organic Chemistry. 76, 15, p. 5936-5953

Research output: Contribution to journalArticle

95 Citations (Scopus)

Investigation of Bispidines as the Stoichiometric Ligand in the Two-Ligand Catalytic Asymmetric Deprotonation of N-Boc Pyrrolidine

Barker, G., O'Brien, P. & Campos, K. R., 2011, In : Arkivoc. 2011, 5, p. 217-229

Research output: Contribution to journalArticle

8 Citations (Scopus)
2010

Asymmetric synthesis via aziridinium ions: exploring the stereospecificity of the ring opening of aziridinium ions and a formal synthesis of (−)-swainsonine

Oxenford, S. J., Moore, S., Carbone, G., Barker, G., O'Brien, P., Shipton, M. R., Gilday, J. & Campos, K. R., 23 Jun 2010, In : Tetrahedron: Asymmetry. 21, 11-12, p. 1563-1568 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Diamine-Free Lithiation−Trapping of N-Boc Heterocycles using s-BuLi in THF

Barker, G., O'Brien, P. & Campos, K. R., 17 Sep 2010, In : Organic Letters. 12, 18, p. 4176-4179 4 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)