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Research Output

2020

3D Printing in Suspension Baths: Keeping the Promises of Bioprinting Afloat

McCormack, A., Highley, C. B., Leslie, N. R. & Melchels, F. P. W., Jun 2020, In : Trends in Biotechnology. 38, 6, p. 584-593 10 p.

Research output: Contribution to journalReview article

Open Access
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2 Citations (Scopus)
20 Downloads (Pure)
2019

Mogelijkheden van 3D-printen in de geneeskunde: 5 jaar later

Translated title of the contribution: Applications of 3D printing in medicine: 5 years laterVisser, J., Melchels, F. P. W., Weinans, H., Kruyt, M. C. & Malda, J., 5 Jun 2019, In : Nederlands Tijdschrift voor Geneeskunde. 163, 23, D3683.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Three dimensional in vitro models of cancer: bioprinting multilineage glioblastoma models

Hermida, M. A., Kumar, J. D., Laverty, K. G., Di Bartolo, A., Ardron, M., Bogomolnijs, M., Clavreul, A., Brennan, P. M., Wiegand, U. K., Melchels, F., Shu, W. & Leslie, N. R., 17 Oct 2019, In : Advances in Biological Regulation. 100658.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Visible Light Cross-Linking of Gelatin Hydrogels Offers an Enhanced Cell Microenvironment with Improved Light Penetration Depth

Lim, K. S., Klotz, B. J., Lindberg, G. C. J., Melchels, F. P. W., Hooper, G. J., Malda, J., Gawlitta, D. & Woodfield, T. B. F., Jun 2019, In : Macromolecular Bioscience. 19, 6, 1900098.

Research output: Contribution to journalArticle

Open Access
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14 Citations (Scopus)
103 Downloads (Pure)
2018

Bio-resin for high resolution lithography-based biofabrication of complex cell-laden constructs

Lim, K. S., Levato, R., Costa, P. F., Castilho, M. D., Alcala-Orozco, C., van Dorenmalen, K. M. A., Melchels, F., Gawlitta, D., Hooper, G. J., Malda, J. & Woodfield, T. B. F., 11 May 2018, In : Biofabrication. 10, 3, 034101.

Research output: Contribution to journalArticle

Open Access
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53 Citations (Scopus)
144 Downloads (Pure)

Comparing Hydrogels for Human Nucleus Pulposus Regeneration: Role of Osmolarity During Expansion

Krouwels, A., Melchels, F. P. W., van Rijen, M. H. P., Öner, F. C., Dhert, W. J. A., Tryfonidou, M. A. & Creemers, L. B., 1 Apr 2018, In : Tissue Engineering Part C: Methods. 24, 4, p. 222-232 11 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
27 Downloads (Pure)

Engineering of a complex bone tissue model with endothelialised channels and capillary-like networks

Klotz, B. J., Lim, K. S., Chang, Y. X., Soliman, B. G., Pennings, I., Melchels, F., Woodfield, T. B. F., Rosenberg, A. J. W. P., Malda, J. & Gawlitta, D., 6 Jun 2018, In : European Cells and Materials . 35, p. 335-349 15 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
63 Downloads (Pure)

Focal adhesion signaling affects regeneration by human nucleus pulposus cells in collagen - but not carbohydrate-based hydrogels

Krouwels, A., Melchels, F. P. W., Van Rijen, M. H. P., ten Brink, C. B. M., Dhert, W. J. A., Öner, F. C., Tryfonidou, M. A. & Creemers, L. B., 15 Jan 2018, In : Acta Biomaterialia. 66, p. 238-247 10 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
31 Downloads (Pure)

One-time delivery of bovine tuberculosis vaccine

Melchels, F., Hope, J. & Stone, V., 15 Oct 2018, In : Impact. 2018, 7, p. 6-8 3 p.

Research output: Contribution to journalArticle

2017

3D bioprinting of methacrylated hyaluronic acid (MeHA) hydrogel with intrinsic osteogenicity

Poldervaart, M. T., Goversen, B., De Ruijter, M., Abbadessa, A., Melchels, F., Öner, F. C., Dhert, W. J. A., Vermonden, T. & Alblas, J., 6 Jun 2017, In : PLoS ONE. 12, 6, e0177628.

Research output: Contribution to journalArticle

Open Access
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60 Citations (Scopus)
36 Downloads (Pure)

Biofabrication in Tissue Engineering

Woodfield, T., Lim, K., Morouço, P., Levato, R., Malda, J. & Melchels, F., 2017, Reference Module in Materials Science and Materials Engineering. Elsevier

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

6 Citations (Scopus)

Improved bovine embryo production in an oviduct-on-a-chip system: prevention of poly-spermic fertilization and parthenogenic activation

Ferraz, M. A. M. M., Henning, H. H. W., Costa, P. F., Malda, J., Melchels, F., Wubbolts, R., Stout, T. A. E., Vos, P. L. A. M. & Gadella, B. M., 7 Mar 2017, In : Lab on a Chip. 17, 5, p. 905-916 12 p.

Research output: Contribution to journalArticle

Open Access
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20 Citations (Scopus)
58 Downloads (Pure)

Proposal to assess printability of bioinks for extrusion-based bioprinting and evaluation of rheological properties governing bioprintability

Paxton, N., Smolan, W., Böck, T., Melchels, F., Groll, J. & Juengst, T., 14 Nov 2017, In : Biofabrication. 9, 4, 044107.

Research output: Contribution to journalArticle

Open Access
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112 Citations (Scopus)
105 Downloads (Pure)
2016

Accurate Measurements of the Skin Surface Area of the Healthy Auricle and Skin Deficiency in Microtia Patients

Otto, I. A., van Doremalen, R. F. M., Melchels, F., Kolodzynski, M. N., Pouran, B., Malda, J., Kon, M. & Breugem, C. C., 22 Dec 2016, In : Plastic and Reconstructive Surgery – Global Open. 4, 12, e1146.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
33 Downloads (Pure)

Functionalization, preparation and use of cell-laden gelatin methacryloyl-based hydrogels as modular tissue culture platforms

Loessner, D., Meinert, C., Kaemmerer, E., Martine, L. C., Yue, K., Levett, P. A., Klein, T. J., Melchels, F. P. W., Khademhosseini, A. & Hutmacher, D. W., Apr 2016, In : Nature Protocols. 11, 4, p. 727-746 20 p.

Research output: Contribution to journalArticle

Open Access
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208 Citations (Scopus)
301 Downloads (Pure)

Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair

Klotz, B. J., Gawlitta, D., Rosenberg, A. J. W. P., Malda, J. & Melchels, F., May 2016, In : Trends in Biotechnology. 34, 5, p. 394–407 14 p.

Research output: Contribution to journalArticle

Open Access
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221 Citations (Scopus)
97 Downloads (Pure)

Hydrogel-based reinforcement of 3D bioprinted constructs

Melchels, F., Blokzijl, M., Levato, R., Peiffer, Q., De Ruijter, M., Hennink, W. E., Vermonden, T. & Malda, J., Sep 2016, In : Biofabrication. 8, 3, 035004.

Research output: Contribution to journalArticle

Open Access
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37 Citations (Scopus)
642 Downloads (Pure)

Yield stress determines bioprintability of hydrogels based on gelatin-methacryloyl and gellan gum for cartilage bioprinting

Mouser, V., Melchels, F., Visser, J., Dhert, W. J. A., Gawlitta, D. & Malda, J., Sep 2016, In : Biofabrication. 8, 3, 035003.

Research output: Contribution to journalArticle

Open Access
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88 Citations (Scopus)
149 Downloads (Pure)
2015

Auricular reconstruction using biofabrication-based tissue engineering strategies

Otto, I. A., Melchels, F. P. W., Zhao, X., Randolph, M. A., Kon, M., Breugem, C. C. & Malda, J., Sep 2015, In : Biofabrication. 7, 3, p. 32001 1 p.

Research output: Contribution to journalArticle

Open Access
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20 Citations (Scopus)
132 Downloads (Pure)

Initial design and physical characterization of a polymeric device for osmosis-driven delayed burst delivery of vaccines

Melchels, F. P. W., Fehr, I., Reitz, A. S., Dunker, U., Beagley, K. W., Dargaville, T. R. & Hutmacher, D. W., Sep 2015, In : Biotechnology and Bioengineering. 112, 9, p. 1927-1935 9 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
55 Downloads (Pure)

Reinforcement of hydrogels using three-dimensionally printed microfibres

Visser, J., Melchels, F. P. W., Jeon, J. E., van Bussel, E. M., Kimpton, L. S., Byrne, H. M., Dhert, W. J. A., Dalton, P. D., Hutmacher, D. W. & Malda, J., Apr 2015, In : Nature Communications. 6, 10 p., 6933.

Research output: Contribution to journalArticle

Open Access
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309 Citations (Scopus)
58 Downloads (Pure)

Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing

Chhaya, M. P., Melchels, F. P. W., Holzapfel, B. M., Baldwin, J. G. & Hutmacher, D. W., Jun 2015, In : Biomaterials. 52, p. 551-560 10 p.

Research output: Contribution to journalArticle

Open Access
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44 Citations (Scopus)
81 Downloads (Pure)
2014

A biomimetic extracellular matrix for cartilage tissue engineering centered on photocurable gelatin, hyaluronic acid and chondroitin sulfate

Levett, P. A., Melchels, F. P. W., Schrobback, K., Hutmacher, D. W., Malda, J. & Klein, T. J., Jan 2014, In : Acta Biomaterialia. 10, 1, p. 214-223 10 p.

Research output: Contribution to journalArticle

Open Access
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185 Citations (Scopus)
66 Downloads (Pure)

Chondrocyte redifferentiation and construct mechanical property development in single-component photocrosslinkable hydrogels

Levett, P. A., Melchels, F. P. W., Schrobback, K., Hutmacher, D. W., Malda, J. & Klein, T. J., Aug 2014, In : Journal of Biomedical Materials Research Part A. 102, 8, p. 2544-2553 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Development and characterisation of a new bioink for additive tissue manufacturing

Melchels, F. P. W., Dhert, W. J. A., Hutmacher, D. W. & Malda, J., 2014, In : Journal of Materials Chemistry B. 2, 16, p. 2282-2289 8 p.

Research output: Contribution to journalArticle

Open Access
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92 Citations (Scopus)
35 Downloads (Pure)

Effects of scaffold architecture on mechanical characteristics and osteoblast response to static and perfusion bioreactor cultures

Bartnikowski, M., Klein, T. J., Melchels, F. P. W. & Woodruff, M. A., Jul 2014, In : Biotechnology and Bioengineering. 111, 7, p. 1440-1451 12 p.

Research output: Contribution to journalArticle

Open Access
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32 Citations (Scopus)
76 Downloads (Pure)

Gelatine methacrylamide-based hydrogels: An alternative three-dimensional cancer cell culture system

Kaemmerer, E., Melchels, F. P. W., Holzapfel, B. M., Meckel, T., Hutmacher, D. W. & Loessner, D., Jun 2014, In : Acta Biomaterialia. 10, 6, p. 2551-2562 12 p.

Research output: Contribution to journalArticle

Open Access
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81 Citations (Scopus)
247 Downloads (Pure)
2013

25th Anniversary Article: Engineering Hydrogels for Biofabrication

Malda, J., Visser, J., Melchels, F. P., Juengst, T., Hennink, W. E., Dhert, W. J. A., Groll, J. & Hutmacher, D. W., 25 Sep 2013, In : Advanced Materials. 25, 36, p. 5011-5028 18 p.

Research output: Contribution to journalLiterature review

Open Access
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726 Citations (Scopus)
430 Downloads (Pure)

Biofabrication of multi-material anatomically shaped tissue constructs

Visser, J., Peters, B., Burger, T. J., Boomstra, J., Dhert, W. J. A., Melchels, F. P. W. & Malda, J., 2 Jul 2013, In : Biofabrication. 5, 3, 9 p., 035007.

Research output: Contribution to journalArticle

Open Access
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153 Citations (Scopus)
85 Downloads (Pure)

Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies

Chhaya, M. P., Melchels, F. P. W., Wiggenhauser, P. S., Schantz, J. T. & Hutmacher, D. W., Mar 2013, Biofabrication: Micro- and Nano-fabrication, Printing, Patterning and Assemblies. Forgacs, G. & Sun, W. (eds.). Elsevier, p. 183-216 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Can bone tissue engineering contribute to therapy concepts after resection of musculoskeletal sarcoma?

Holzapfel, B. M., Chhaya, M. P., Melchels, F. P. W., Holzapfel, N. P., Prodinger, P. M., Von Eisenhart-Rothe, R., Van Griensven, M., Schantz, J. T., Rudert, M. & Hutmacher, D. W., 2013, In : Sarcoma. 2013, 10 p., 153640.

Research output: Contribution to journalArticle

Open Access
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20 Citations (Scopus)
85 Downloads (Pure)

Gelatin-Methacrylamide Hydrogels as Potential Biomaterials for Fabrication of Tissue-Engineered Cartilage Constructs

Schuurman, W., Levett, P. A., Pot, M. W., van Weeren, P. R., Dhert, W. J. A., Hutmacher, D. W., Melchels, F. P. W., Klein, T. J. & Malda, J., May 2013, In : Macromolecular Bioscience. 13, 5, p. 551-561 11 p.

Research output: Contribution to journalArticle

337 Citations (Scopus)

Weefsel uit de printer: de mogelijkheden van 3D-printen in de geneeskunde

Translated title of the contribution: Tissue printing; the potential application of 3D printing in medicineVisser, J., Melchels, F. P. W., Dhert, W. J. A. & Malda, J., 2013, In : Nederlands Tijdschrift voor Geneeskunde. 157, 52

Research output: Contribution to journalArticle

6 Citations (Scopus)
2012

A biodegradable, delayed burst-release device for the delivery of vaccine 'booster shots'

Clark, A. M., Melchels, F. P. W., Dargaville, T. R., Timms, P., Beagley, K. & Hutmacher, D. W., Sep 2012, In : Journal of Tissue Engineering and Regenerative Medicine. 6, Suppl. 1, p. 325 1 p.

Research output: Contribution to journalMeeting abstract

Additive manufacturing of tissues and organs

Melchels, F. P. W., Domingos, M. A. N., Klein, T. J., Malda, J., Bartolo, P. J. & Hutmacher, D. W., Aug 2012, In : Progress in Polymer Science. 37, 8, p. 1079-1104 26 p.

Research output: Contribution to journalLiterature review

Open Access
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664 Citations (Scopus)
239 Downloads (Pure)

Celebrating three decades of stereolithography

Melchels, F. P. W., Sep 2012, In : Virtual and Physical Prototyping. 7, 3, p. 173-175 3 p.

Research output: Contribution to journalEditorial

Open Access
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8 Citations (Scopus)
118 Downloads (Pure)

Engineering of vascularized adipose constructs

Wiggenhauser, P. S., Müller, D. F., Melchels, F. P. W., Egaña, J. T., Storck, K., Mayer, H., Leuthner, P., Skodacek, D., Hopfner, U., Machens, H. G., Staudenmaier, R. & Schantz, J. T., Mar 2012, In : Cell and Tissue Research. 347, 3, p. 747-757 11 p.

Research output: Contribution to journalArticle

Open Access
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33 Citations (Scopus)
51 Downloads (Pure)

Photocrosslinkable hydrogels for cartilage tissue engineering

Levett, P. A., Melchels, F. P., Schrobback, K., Hutmacher, D. W., Malda, J. & Klein, T. J., Sep 2012, In : Journal of Tissue Engineering and Regenerative Medicine. 6, Suppl. 1, p. 68 1 p.

Research output: Contribution to journalMeeting abstract

Polycaprolactone-based scaffold plus BMP-2 in a sheep thoracic spine fusion model

Yong, M., Melchels, F., Vaquette, C., Hutmacher, D., Adam, C., Domingos, M. & Bartolo, P., 2012, Innovative Developments in Virtual and Physical Prototyping: Proceedings of the 5th International Conference on Advanced Research in Virtual and Rapid Prototyping, Leiria, Portugal, 28 September - 1 October, 2011. CRC Press, p. 89-92 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)
2011

CAD/CAM-assisted breast reconstruction

Melchels, F., Wiggenhauser, P. S., Warne, D., Barry, M., Ong, F. R., Chong, W. S., Hutmacher, D. W. & Schantz, J. T., 7 Sep 2011, In : Biofabrication. 3, 3, 034114.

Research output: Contribution to journalArticle

Open Access
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34 Citations (Scopus)
119 Downloads (Pure)

Organ printing

Melchels, F., Malda, J., Fedorovich, N., Alblas, J. & Woodfield, T., Oct 2011, Comprehensive Biomaterials. Elsevier, Vol. 5. p. 587-606 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

The influence of the scaffold design on the distribution of adhering cells after perfusion cell seeding

Melchels, F. P. W., Tonnarelli, B., Olivares, A. L., Martin, I., Lacroix, D., Feijen, J., Wendt, D. J. & Grijpma, D. W., Apr 2011, In : Biomaterials. 32, 11, p. 2878-2884 7 p.

Research output: Contribution to journalArticle

Open Access
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89 Citations (Scopus)
67 Downloads (Pure)
2010

A review on stereolithography and its applications in biomedical engineering

Melchels, F. P. W., Feijen, J. & Grijpma, D. W., Aug 2010, In : Biomaterials. 31, 24, p. 6121-6130 10 p.

Research output: Contribution to journalArticle

Open Access
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925 Citations (Scopus)
413 Downloads (Pure)

Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(d,l-lactide)-based resins

Seck, T. M., Melchels, F. P. W., Feijen, J. & Grijpma, D. W., 20 Nov 2010, In : Journal of Controlled Release. 148, 1, p. 34-41 8 p.

Research output: Contribution to journalArticle

Open Access
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107 Citations (Scopus)
45 Downloads (Pure)

Effects of the architecture of tissue engineering scaffolds on cell seeding and culturing

Melchels, F. P. W., Barradas, A. M. C., Van Blitterswijk, C. A., De Boer, J., Feijen, J. & Grijpma, D. W., Nov 2010, In : Acta Biomaterialia. 6, 11, p. 4208-4217 10 p.

Research output: Contribution to journalArticle

221 Citations (Scopus)

Mathematically defined tissue engineering scaffold architectures prepared by stereolithography

Melchels, F. P. W., Bertoldi, K., Gabbrielli, R., Velders, A. H., Feijen, J. & Grijpma, D. W., Sep 2010, In : Biomaterials. 31, 27, p. 6909-6916 8 p.

Research output: Contribution to journalArticle

Open Access
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257 Citations (Scopus)
221 Downloads (Pure)

Photo-Cross-Linked Poly(dl-lactide)-Based Networks. Structural Characterization by HR-MAS NMR Spectroscopy and Hydrolytic Degradation Behavior

Melchels, F. P. W., Velders, A. H., Feijen, J. & Grijpma, D. W., 26 Oct 2010, In : Macromolecules. 43, 20, p. 8570-8579 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2009

A poly(d,l-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography

Melchels, F. P. W., Feijen, J. & Grijpma, D. W., Aug 2009, In : Biomaterials. 30, 23-24, p. 3801-3809 9 p.

Research output: Contribution to journalArticle

Open Access
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247 Citations (Scopus)
75 Downloads (Pure)

Fumaric Acid Monoethyl Ester-Functionalized Poly(d,l-lactide)/N-vinyl-2-pyrrolidone Resins for the Preparation of Tissue Engineering Scaffolds by Stereolithography

Jansen, J., Melchels, F. P. W., Grijpma, D. W. & Feijen, J., 9 Feb 2009, In : Biomacromolecules. 10, 2, p. 214-220 7 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)
2008

A review of rapid prototyping techniques for tissue engineering purposes

Peltola, S. M., Melchels, F. P. W., Grijpma, D. W. & Kellomäki, M., 2008, In : Annals of Medicine. 40, 4, p. 268-280 13 p.

Research output: Contribution to journalArticle

Open Access
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460 Citations (Scopus)
71 Downloads (Pure)