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Research Output 2006 2019

2019

Mogelijkheden van 3D-printen in de geneeskunde: 5 jaar later

Visser, J., Melchels, F. P. W., Weinans, H., Kruyt, M. C. & Malda, J., 5 Jun 2019, In : Nederlands Tijdschrift voor Geneeskunde. 163, 23, D3683.

Research output: Contribution to journalArticle

Bioprinting
Medicine
Printing
Biocompatible Materials
Titanium

Visible Light Cross-Linking of Gelatin Hydrogels Offers an Enhanced Cell Microenvironment with Improved Light Penetration Depth

Lim, K. S., Klotz, B. J., Lindberg, G. C. J., Melchels, F. P. W., Hooper, G. J., Malda, J., Gawlitta, D. & Woodfield, T. B. F., Jun 2019, In : Macromolecular Bioscience. 19, 6, 1900098.

Research output: Contribution to journalArticle

File
Cellular Microenvironment
Hydrogels
Ruthenium
Gelatin
Light
2018

Bio-resin for high resolution lithography-based biofabrication of complex cell-laden constructs

Lim, K. S., Levato, R., Costa, P. F., Castilho, M. D., Alcala-Orozco, C., van Dorenmalen, K. M. A., Melchels, F., Gawlitta, D., Hooper, G. J., Malda, J. & Woodfield, T. B. F., 11 May 2018, In : Biofabrication. 10, 3, 034101.

Research output: Contribution to journalArticle

Open Access
File
Lithography
Gelatin
Resins
Printing
Hydrogels

Comparing Hydrogels for Human Nucleus Pulposus Regeneration: Role of Osmolarity During Expansion

Krouwels, A., Melchels, F. P. W., van Rijen, M. H. P., Öner, F. C., Dhert, W. J. A., Tryfonidou, M. A. & Creemers, L. B., 1 Apr 2018, In : Tissue Engineering Part C: Methods. 24, 4, p. 222-232 11 p.

Research output: Contribution to journalArticle

Open Access
File
Hydrogels
Osmolar Concentration
Regeneration
Collagen Type II
Sepharose

Engineering of a complex bone tissue model with endothelialised channels and capillary-like networks

Klotz, B. J., Lim, K. S., Chang, Y. X., Soliman, B. G., Pennings, I., Melchels, F., Woodfield, T. B. F., Rosenberg, A. J. W. P., Malda, J. & Gawlitta, D., 6 Jun 2018, In : European Cells and Materials . 35, p. 335-349 15 p.

Research output: Contribution to journalArticle

Open Access
File
Bone and Bones
Hydrogel
Tissue Engineering
Osteogenesis
Endothelium

Focal adhesion signaling affects regeneration by human nucleus pulposus cells in collagen - but not carbohydrate-based hydrogels

Krouwels, A., Melchels, F. P. W., Van Rijen, M. H. P., ten Brink, C. B. M., Dhert, W. J. A., Öner, F. C., Tryfonidou, M. A. & Creemers, L. B., 15 Jan 2018, In : Acta Biomaterialia. 66, p. 238-247 10 p.

Research output: Contribution to journalArticle

Open Access
File
Hydrogels
Focal Adhesions
Regeneration
Collagen
Carbohydrates

One-time delivery of bovine tuberculosis vaccine

Melchels, F., Hope, J. & Stone, V., 15 Oct 2018, In : Impact. 2018, 7, p. 6-8 3 p.

Research output: Contribution to journalArticle

Vaccines
Animals
Osmosis
Sugars
Printing
2017

3D bioprinting of methacrylated hyaluronic acid (MeHA) hydrogel with intrinsic osteogenicity

Poldervaart, M. T., Goversen, B., De Ruijter, M., Abbadessa, A., Melchels, F., Öner, F. C., Dhert, W. J. A., Vermonden, T. & Alblas, J., 6 Jun 2017, In : PLoS ONE. 12, 6, e0177628.

Research output: Contribution to journalArticle

Open Access
File
Bioprinting
Hydrogels
Hydrogel
Hyaluronic Acid
Gels

Biofabrication in Tissue Engineering

Woodfield, T., Lim, K., Morouço, P., Levato, R., Malda, J. & Melchels, F., 2017, Reference Module in Materials Science and Materials Engineering. Elsevier

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

Tissue Engineering
Bioprinting
Organoids
Biomedical Engineering
Technology

Improved bovine embryo production in an oviduct-on-a-chip system: prevention of poly-spermic fertilization and parthenogenic activation

Ferraz, M. A. M. M., Henning, H. H. W., Costa, P. F., Malda, J., Melchels, F., Wubbolts, R., Stout, T. A. E., Vos, P. L. A. M. & Gadella, B. M., 7 Mar 2017, In : Lab on a Chip. 17, 5, p. 905-916 12 p.

Research output: Contribution to journalArticle

Open Access
File
fertilization (reproduction)
oviducts
embryo (animal)
cattle
oocytes

Proposal to assess printability of bioinks for extrusion-based bioprinting and evaluation of rheological properties governing bioprintability

Paxton, N., Smolan, W., Böck, T., Melchels, F., Groll, J. & Juengst, T., 14 Nov 2017, In : Biofabrication. 9, 4, 044107.

Research output: Contribution to journalArticle

Open Access
File
Ink
Extrusion
Shear thinning
Needles
Mathematical models
2016

Accurate Measurements of the Skin Surface Area of the Healthy Auricle and Skin Deficiency in Microtia Patients

Otto, I. A., van Doremalen, R. F. M., Melchels, F., Kolodzynski, M. N., Pouran, B., Malda, J., Kon, M. & Breugem, C. C., 22 Dec 2016, In : Plastic and Reconstructive Surgery – Global Open. 4, 12, e1146.

Research output: Contribution to journalArticle

Open Access
File
Skin
Ear
Congenital Microtia
Tissue Engineering
Netherlands

Functionalization, preparation and use of cell-laden gelatin methacryloyl-based hydrogels as modular tissue culture platforms

Loessner, D., Meinert, C., Kaemmerer, E., Martine, L. C., Yue, K., Levett, P. A., Klein, T. J., Melchels, F. P. W., Khademhosseini, A. & Hutmacher, D. W., Apr 2016, In : Nature Protocols. 11, 4, p. 727-746 20 p.

Research output: Contribution to journalArticle

Open Access
File
Hydrogels
Gelatin
Cell Culture Techniques
Stem Cell Research
Biological Models

Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair

Klotz, B. J., Gawlitta, D., Rosenberg, A. J. W. P., Malda, J. & Melchels, F., May 2016, In : Trends in Biotechnology. 34, 5, p. 394–407 14 p.

Research output: Contribution to journalArticle

Open Access
File
Hydrogels
Gelatin
Repair
Tissue
Bioactivity

Hydrogel-based reinforcement of 3D bioprinted constructs

Melchels, F., Blokzijl, M., Levato, R., Peiffer, Q., De Ruijter, M., Hennink, W. E., Vermonden, T. & Malda, J., Sep 2016, In : Biofabrication. 8, 3, 035004.

Research output: Contribution to journalArticle

Open Access
File
Hydrogels
Reinforcement
Gels
Printing
Degradation

Yield stress determines bioprintability of hydrogels based on gelatin-methacryloyl and gellan gum for cartilage bioprinting

Mouser, V., Melchels, F., Visser, J., Dhert, W. J. A., Gawlitta, D. & Malda, J., Sep 2016, In : Biofabrication. 8, 3, 035003.

Research output: Contribution to journalArticle

Open Access
File
bioprinting
gellan gum
hydrocolloids
gelatin
cartilage
2015

Auricular reconstruction using biofabrication-based tissue engineering strategies

Otto, I. A., Melchels, F. P. W., Zhao, X., Randolph, M. A., Kon, M., Breugem, C. C. & Malda, J., Sep 2015, In : Biofabrication. 7, 3, p. 32001 1 p.

Research output: Contribution to journalArticle

Open Access
File
Tissue Engineering
Technology
Cartilage
Ear Cartilage
Regenerative Medicine

Initial design and physical characterization of a polymeric device for osmosis-driven delayed burst delivery of vaccines

Melchels, F. P. W., Fehr, I., Reitz, A. S., Dunker, U., Beagley, K. W., Dargaville, T. R. & Hutmacher, D. W., Sep 2015, In : Biotechnology and Bioengineering. 112, 9, p. 1927-1935 9 p.

Research output: Contribution to journalArticle

Open Access
File

Reinforcement of hydrogels using three-dimensionally printed microfibres

Visser, J., Melchels, F. P. W., Jeon, J. E., van Bussel, E. M., Kimpton, L. S., Byrne, H. M., Dhert, W. J. A., Dalton, P. D., Hutmacher, D. W. & Malda, J., Apr 2015, In : Nature Communications. 6, 10 p., 6933.

Research output: Contribution to journalArticle

Open Access
File

Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing

Chhaya, M. P., Melchels, F. P. W., Holzapfel, B. M., Baldwin, J. G. & Hutmacher, D. W., Jun 2015, In : Biomaterials. 52, p. 551-560 10 p.

Research output: Contribution to journalArticle

Open Access
File
2014

A biomimetic extracellular matrix for cartilage tissue engineering centered on photocurable gelatin, hyaluronic acid and chondroitin sulfate

Levett, P. A., Melchels, F. P. W., Schrobback, K., Hutmacher, D. W., Malda, J. & Klein, T. J., Jan 2014, In : Acta Biomaterialia. 10, 1, p. 214-223 10 p.

Research output: Contribution to journalArticle

Open Access
File

Chondrocyte redifferentiation and construct mechanical property development in single-component photocrosslinkable hydrogels

Levett, P. A., Melchels, F. P. W., Schrobback, K., Hutmacher, D. W., Malda, J. & Klein, T. J., Aug 2014, In : Journal of Biomedical Materials Research Part A. 102, 8, p. 2544-2553 10 p.

Research output: Contribution to journalArticle

Hydrogels
Chondrocytes
Mechanical properties
Cartilage
Hyaluronic acid

Development and characterisation of a new bioink for additive tissue manufacturing

Melchels, F. P. W., Dhert, W. J. A., Hutmacher, D. W. & Malda, J., 2014, In : Journal of Materials Chemistry B. 2, 16, p. 2282-2289 8 p.

Research output: Contribution to journalArticle

Open Access
File

Effects of scaffold architecture on mechanical characteristics and osteoblast response to static and perfusion bioreactor cultures

Bartnikowski, M., Klein, T. J., Melchels, F. P. W. & Woodruff, M. A., Jul 2014, In : Biotechnology and Bioengineering. 111, 7, p. 1440-1451 12 p.

Research output: Contribution to journalArticle

Open Access
File

Gelatine methacrylamide-based hydrogels: An alternative three-dimensional cancer cell culture system

Kaemmerer, E., Melchels, F. P. W., Holzapfel, B. M., Meckel, T., Hutmacher, D. W. & Loessner, D., Jun 2014, In : Acta Biomaterialia. 10, 6, p. 2551-2562 12 p.

Research output: Contribution to journalArticle

Open Access
File
2013

25th Anniversary Article: Engineering Hydrogels for Biofabrication

Malda, J., Visser, J., Melchels, F. P., Juengst, T., Hennink, W. E., Dhert, W. J. A., Groll, J. & Hutmacher, D. W., 25 Sep 2013, In : Advanced Materials. 25, 36, p. 5011-5028 18 p.

Research output: Contribution to journalLiterature review

Open Access
File

Biofabrication of multi-material anatomically shaped tissue constructs

Visser, J., Peters, B., Burger, T. J., Boomstra, J., Dhert, W. J. A., Melchels, F. P. W. & Malda, J., 2 Jul 2013, In : Biofabrication. 5, 3, 9 p., 035007.

Research output: Contribution to journalArticle

Open Access
File

Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies

Chhaya, M. P., Melchels, F. P. W., Wiggenhauser, P. S., Schantz, J. T. & Hutmacher, D. W., Mar 2013, Biofabrication: Micro- and Nano-fabrication, Printing, Patterning and Assemblies. Forgacs, G. & Sun, W. (eds.). Elsevier, p. 183-216 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tissue engineering
Tissue
3D printers
Cosmetics
Silicones

Can bone tissue engineering contribute to therapy concepts after resection of musculoskeletal sarcoma?

Holzapfel, B. M., Chhaya, M. P., Melchels, F. P. W., Holzapfel, N. P., Prodinger, P. M., Von Eisenhart-Rothe, R., Van Griensven, M., Schantz, J. T., Rudert, M. & Hutmacher, D. W., 2013, In : Sarcoma. 2013, 10 p., 153640.

Research output: Contribution to journalArticle

Open Access
File
Tissue Engineering
Sarcoma
Bone and Bones
Orthopedics
Seroma

Gelatin-Methacrylamide Hydrogels as Potential Biomaterials for Fabrication of Tissue-Engineered Cartilage Constructs

Schuurman, W., Levett, P. A., Pot, M. W., van Weeren, P. R., Dhert, W. J. A., Hutmacher, D. W., Melchels, F. P. W., Klein, T. J. & Malda, J., May 2013, In : Macromolecular Bioscience. 13, 5, p. 551-561 11 p.

Research output: Contribution to journalArticle

Weefsel uit de printer: de mogelijkheden van 3D-printen in de geneeskunde

Visser, J., Melchels, F. P. W., Dhert, W. J. A. & Malda, J., 2013, In : Nederlands Tijdschrift voor Geneeskunde. 157, 52

Research output: Contribution to journalArticle

Printing
Medicine
Bioprinting
Regenerative Medicine
Biocompatible Materials
2012

A biodegradable, delayed burst-release device for the delivery of vaccine 'booster shots'

Clark, A. M., Melchels, F. P. W., Dargaville, T. R., Timms, P., Beagley, K. & Hutmacher, D. W., Sep 2012, In : Journal of Tissue Engineering and Regenerative Medicine. 6, Suppl. 1, p. 325 1 p.

Research output: Contribution to journalMeeting abstract

Additive manufacturing of tissues and organs

Melchels, F. P. W., Domingos, M. A. N., Klein, T. J., Malda, J., Bartolo, P. J. & Hutmacher, D. W., Aug 2012, In : Progress in Polymer Science. 37, 8, p. 1079-1104 26 p.

Research output: Contribution to journalLiterature review

Open Access
File

Celebrating three decades of stereolithography

Melchels, F. P. W., Sep 2012, In : Virtual and Physical Prototyping. 7, 3, p. 173-175 3 p.

Research output: Contribution to journalEditorial

Open Access
File

Engineering of vascularized adipose constructs

Wiggenhauser, P. S., Müller, D. F., Melchels, F. P. W., Egaña, J. T., Storck, K., Mayer, H., Leuthner, P., Skodacek, D., Hopfner, U., Machens, H. G., Staudenmaier, R. & Schantz, J. T., Mar 2012, In : Cell and Tissue Research. 347, 3, p. 747-757 11 p.

Research output: Contribution to journalArticle

Open Access
File
Adipose Tissue
Tissue Engineering
Adipogenesis
Polyurethanes
Porifera

Photocrosslinkable hydrogels for cartilage tissue engineering

Levett, P. A., Melchels, F. P., Schrobback, K., Hutmacher, D. W., Malda, J. & Klein, T. J., Sep 2012, In : Journal of Tissue Engineering and Regenerative Medicine. 6, Suppl. 1, p. 68 1 p.

Research output: Contribution to journalMeeting abstract

Polycaprolactone-based scaffold plus BMP-2 in a sheep thoracic spine fusion model

Yong, M., Melchels, F., Vaquette, C., Hutmacher, D., Adam, C., Domingos, M. & Bartolo, P., 2012, Innovative Developments in Virtual and Physical Prototyping: Proceedings of the 5th International Conference on Advanced Research in Virtual and Rapid Prototyping, Leiria, Portugal, 28 September - 1 October, 2011. CRC Press, p. 89-92 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Polycaprolactone
Scaffolds
Bone
Fusion reactions
Layered manufacturing
2011

CAD/CAM-assisted breast reconstruction

Melchels, F., Wiggenhauser, P. S., Warne, D., Barry, M., Ong, F. R., Chong, W. S., Hutmacher, D. W. & Schantz, J. T., 7 Sep 2011, In : Biofabrication. 3, 3, 034114.

Research output: Contribution to journalArticle

Open Access
File
Computer-Aided Design
Mammaplasty
Computer aided manufacturing
Computer aided design
Breast

Organ printing

Melchels, F., Malda, J., Fedorovich, N., Alblas, J. & Woodfield, T., Oct 2011, Comprehensive Biomaterials. Elsevier, Vol. 5. p. 587-606 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The influence of the scaffold design on the distribution of adhering cells after perfusion cell seeding

Melchels, F. P. W., Tonnarelli, B., Olivares, A. L., Martin, I., Lacroix, D., Feijen, J., Wendt, D. J. & Grijpma, D. W., Apr 2011, In : Biomaterials. 32, 11, p. 2878-2884 7 p.

Research output: Contribution to journalArticle

Open Access
File
Scaffolds
Perfusion
Porosity
Shear deformation
Cell Count
2010

A review on stereolithography and its applications in biomedical engineering

Melchels, F. P. W., Feijen, J. & Grijpma, D. W., Aug 2010, In : Biomaterials. 31, 24, p. 6121-6130 10 p.

Research output: Contribution to journalArticle

Open Access
File
Biomedical Engineering
Stereolithography
Biomedical engineering
Tissue Engineering
Tissue engineering

Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(d,l-lactide)-based resins

Seck, T. M., Melchels, F. P. W., Feijen, J. & Grijpma, D. W., 20 Nov 2010, In : Journal of Controlled Release. 148, 1, p. 34-41 8 p.

Research output: Contribution to journalArticle

Open Access
File
Ethylene Glycol
Hydrogel
Hydrogels
Dimethyl Sulfoxide
Mesenchymal Stromal Cells

Effects of the architecture of tissue engineering scaffolds on cell seeding and culturing

Melchels, F. P. W., Barradas, A. M. C., Van Blitterswijk, C. A., De Boer, J., Feijen, J. & Grijpma, D. W., Nov 2010, In : Acta Biomaterialia. 6, 11, p. 4208-4217 10 p.

Research output: Contribution to journalArticle

Tissue Scaffolds
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Scaffolds

Mathematically defined tissue engineering scaffold architectures prepared by stereolithography

Melchels, F. P. W., Bertoldi, K., Gabbrielli, R., Velders, A. H., Feijen, J. & Grijpma, D. W., Sep 2010, In : Biomaterials. 31, 27, p. 6909-6916 8 p.

Research output: Contribution to journalArticle

Open Access
File
Tissue Scaffolds
Stereolithography
Tissue Engineering
Scaffolds (biology)
Tissue engineering

Photo-Cross-Linked Poly(dl-lactide)-Based Networks. Structural Characterization by HR-MAS NMR Spectroscopy and Hydrolytic Degradation Behavior

Melchels, F. P. W., Velders, A. H., Feijen, J. & Grijpma, D. W., 26 Oct 2010, In : Macromolecules. 43, 20, p. 8570-8579 10 p.

Research output: Contribution to journalArticle

Chain length
Nuclear magnetic resonance spectroscopy
Molecular weight
Degradation
Kinetics
2009

A poly(d,l-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography

Melchels, F. P. W., Feijen, J. & Grijpma, D. W., Aug 2009, In : Biomaterials. 30, 23-24, p. 3801-3809 9 p.

Research output: Contribution to journalArticle

Open Access
File
Tissue Scaffolds
Stereolithography
Tissue Engineering
Scaffolds (biology)
Tissue engineering

Fumaric Acid Monoethyl Ester-Functionalized Poly(d,l-lactide)/N-vinyl-2-pyrrolidone Resins for the Preparation of Tissue Engineering Scaffolds by Stereolithography

Jansen, J., Melchels, F. P. W., Grijpma, D. W. & Feijen, J., 9 Feb 2009, In : Biomacromolecules. 10, 2, p. 214-220 7 p.

Research output: Contribution to journalArticle

Tissue Scaffolds
Stereolithography
Scaffolds (biology)
Tissue engineering
Oligomers
2008

A review of rapid prototyping techniques for tissue engineering purposes

Peltola, S. M., Melchels, F. P. W., Grijpma, D. W. & Kellomäki, M., 2008, In : Annals of Medicine. 40, 4, p. 268-280 13 p.

Research output: Contribution to journalArticle

Open Access
File
Tissue Engineering
Tissue Scaffolds
Computer-Aided Design
Porosity
Cell Adhesion

Evaluation of osteogenic human multipotent precursor cells from peripheral blood on PLA-based scaffolds for bone tissue engineering

Pu, F. R., Rhodes, N. P., Melchels, F., Grijpma, D. W. & Hunt, J. A., 2008, 8th World Biomaterials Congress 2008. Curran Associates, Inc., Vol. 2. p. 981 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

PDLLA-fumarate/NVP resin for bone tissue engineering applications

Jansen, J., Melchels, F. P. W., Grijpma, D. W. & Feijen, J., 2008, 8th World Biomaterials Congress 2008. Curran Associates, Inc., Vol. 3. p. 1587 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution