Research Output per year
Personal profile
Research interests
Euan Brown works in the interface between Biomedical Science and Biophysics with particular emphasis on bioelectricity. His current interests are focused on membrane ion channels which are nanoscale molecular machines (proteins) that permit membrane based signals such as secretion, neurotransmission and electrical conduction to occur. Native and abiotic ion channels have great potential in the field of bioengineering and drug discovery.
Current Projects
Ligand and voltage-gated ion channels as sensors
Current projects involve the use of heterologously expressed hERG (human Ether-à-go-go-Related Gene product) cardiac (Kv 11.1) K+ channels in a medium throughput system for substance screening. This channel is key in stabilizing the regularity of heart beats. Drugs or substances that act on hERG have potential cardio- active properties. We are currently screening compounds on biomembranes such as bioactive fractions from marine sponges and nanomaterials. We will be developing microfluidic devices to solve drug concentration problems where the behaviour of substances in solution is dynamic (e.g Nanomedicines).
Role of voltage gated Calcium channels in excitability.
Many endocrine and neuronal cell classes are ‘spontaneously’ electrically active. In this project we are examining the role of voltage gated calcium channels (VGCC). We are studying the rules governing the spatial- temporal organization of calcium channels in relation to other intracellular proteins to understand how this behaviour develops and is maintained. These mechanisms can only be understood by combining high resolution imaging and advanced biophysical measurement of whole- cell and single calcium channel activity. We are developing the technology to couple TIRFM imaging and electrophysiology of calcium channels in muscle and synaptic zones. The results will have an impact on understanding the role of calcium channels in both health and disease and will push forward the associated technology.
A microfluidic chip for MS research (funded by Medical Research Scotland and Epigem Ltd).
In collaboration with Epigem Ltd, we are developing a neuronal chip with built- in electrical stimulation and measurement to study the excitability changes that occur in Multiple Sclerosis (MS). The project involve combining culture of human stem cells, multi-electrode arrays and microfluidic technology.
Keywords
- QP Physiology
- biophysics
- Physiology
- neuroscience
- nanomaterials
- QL Zoology
Fingerprint Dive into the research topics where Euan R. Brown is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
Co Author Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2000 2019
An in vitro model for studying CNS white matter: functional properties and experimental approaches
Bijland, S., Thomson, G., Euston, M., Michail, K., Thümmler, K., Mücklisch, S., Crawford, C. L., Barnett, S. C., McLaughlin, M., Anderson, T. J., Linington, C., Brown, E. R., Kalkman, E. R. & Edgar, J. M., 29 Jan 2019, In : F1000Research . 8, 117.Research output: Contribution to journal › Article
Zinc Oxide Nanoparticles and Voltage-Gated Human Kv11.1 Potassium Channels Interact through a Novel Mechanism
Piscopo, S. & Brown, E. R., 26 Feb 2018, In : Small. 1703403.Research output: Contribution to journal › Article
Mechanism of neutrophil activation and toxicity elicited by engineered nanomaterials
Johnston, H. J., Brown, D. M., Kanase, N., Euston, M., Gaiser, B. K., Robb, C. T., Dyrynda, E., Rossi, A. G., Brown, E. R. & Stone, V., Aug 2015, In : Toxicology in Vitro. 29, 5, p. 1172-1184 13 p.Research output: Contribution to journal › Article
A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion
Kavanagh, D., Smyth, A. M., Martin, K. J., Dun, A., Brown, E. R., Gordon, S., Smillie, K. J., Chamberlain, L. H., Wilson, R. S., Yang, L., Lu, W., Cousin, M. A., Rickman, C. & Duncan, R. R., 2014, In : Nature Communications. 5, 5774.Research output: Contribution to journal › Article
Chapter 6: Primary Production, Cycling of Nutrients, Surface Layer and Plankton
Malone, T., Azzaro, M., Bode, A., Brown, E. R., Duce, R., Kamykowski, D., Sung-Ho, K., Kedong, Y., Thorndyke, M., Wang, J., Park, C., Calumpong, H. & Eghtesadi Araghi, P., 23 Dec 2015, First Global Integrated Marine Assessment, also known as the first World Ocean Assessment: World Ocean Assessment I. United Nations, 67 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)
Activities 2008 2016
European Commission (External organisation)
Euan R Brown (Member)Activity: Membership › Membership of peer review panel
UN Division for Ocean Affairs and the Law of the Sea (External organisation)
Euan R Brown (Member)Activity: Membership › Membership of committee
Explorathon'15
Euan R Brown (Speaker)Activity: Participating in or organising an event › Participation in Festival or Exhibition
European Commission (External organisation)
Euan R Brown (Member)Activity: Membership › Membership of peer review panel
Frontiers in Cellular Neuroscience (Journal)
Euan R Brown (Editorial board member)Activity: Publication peer-review and editorial work › Editorial activity