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Personal profile

Research interests

Euan Brown works in the interface between Biomedical Science and Biophysics with particular emphasis on bioelectricity.  His current interests are focused on membrane ion channels which are nanoscale molecular machines (proteins) that permit membrane based signals such as secretion, neurotransmission and electrical conduction to occur.  Native and abiotic ion channels have great potential in the field of bioengineering and drug discovery.

Current Projects

Ligand and voltage-gated ion channels as sensors

Current projects involve the use of heterologously expressed hERG (human Ether-à-go-go-Related Gene product) cardiac (Kv 11.1) K+ channels in a medium throughput system for substance screening. This channel is key in stabilizing the regularity of heart beats. Drugs or substances that act on hERG have potential cardio- active properties. We are currently screening compounds on biomembranes such as bioactive fractions from marine sponges and nanomaterials. We will be developing microfluidic devices to solve drug concentration problems where the behaviour of substances in solution is dynamic (e.g Nanomedicines).

Role of voltage gated Calcium channels in excitability.

Many endocrine and neuronal cell classes are ‘spontaneously’ electrically active.  In this project we are examining the role of  voltage gated calcium channels (VGCC).   We are studying the  rules governing  the spatial- temporal organization of calcium channels in relation to other intracellular proteins to  understand how this behaviour develops and  is maintained.  These mechanisms can only be understood by combining high resolution imaging and advanced biophysical measurement of whole- cell and single calcium channel activity. We are developing the technology to couple TIRFM imaging and electrophysiology of calcium channels in muscle and synaptic zones. The results will have an impact on understanding the role of calcium channels in both health and disease and will push forward the associated technology.

A microfluidic chip for  MS research (funded by Medical Research Scotland and Epigem Ltd).

In collaboration with Epigem Ltd, we are developing a neuronal chip with built- in electrical stimulation and measurement to study the excitability changes that occur in Multiple Sclerosis (MS).  The project involve combining culture of human stem cells, multi-electrode arrays and microfluidic technology.  

Keywords

  • QP Physiology
  • biophysics
  • Physiology
  • neuroscience
  • nanomaterials
  • QL Zoology

Fingerprint Dive into the research topics where Euan R. Brown is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Ciona intestinalis Medicine & Life Sciences
Urochordata Medicine & Life Sciences
Vertebrates Medicine & Life Sciences
Larva Medicine & Life Sciences
Ion Channels Medicine & Life Sciences
Synaptic Transmission Medicine & Life Sciences
Chordata Medicine & Life Sciences
Nonvertebrate Chordata Medicine & Life Sciences

Co Author Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2000 2019

  • 33 Article
  • 1 Chapter (peer-reviewed)
  • 1 Meeting abstract

An in vitro model for studying CNS white matter: functional properties and experimental approaches

Bijland, S., Thomson, G., Euston, M., Michail, K., Thümmler, K., Mücklisch, S., Crawford, C. L., Barnett, S. C., McLaughlin, M., Anderson, T. J., Linington, C., Brown, E. R., Kalkman, E. R. & Edgar, J. M., 29 Jan 2019, In : F1000Research . 8, 117.

Research output: Contribution to journalArticle

Open Access
File
Time-Lapse Imaging
Motor Neuron Disease
Endocrine System
Electrophysiology
Oligodendroglia

Zinc Oxide Nanoparticles and Voltage-Gated Human Kv11.1 Potassium Channels Interact through a Novel Mechanism

Piscopo, S. & Brown, E. R., 26 Feb 2018, In : Small. 1703403.

Research output: Contribution to journalArticle

Open Access
File
Zinc Oxide
Potassium Channels
Zinc oxide
Nanoparticles
Potassium

Mechanism of neutrophil activation and toxicity elicited by engineered nanomaterials

Johnston, H. J., Brown, D. M., Kanase, N., Euston, M., Gaiser, B. K., Robb, C. T., Dyrynda, E., Rossi, A. G., Brown, E. R. & Stone, V., Aug 2015, In : Toxicology in Vitro. 29, 5, p. 1172-1184 13 p.

Research output: Contribution to journalArticle

nanomaterials
Neutrophil Activation
Nanostructures
Nanostructured materials
Toxicity

A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion

Kavanagh, D., Smyth, A. M., Martin, K. J., Dun, A., Brown, E. R., Gordon, S., Smillie, K. J., Chamberlain, L. H., Wilson, R. S., Yang, L., Lu, W., Cousin, M. A., Rickman, C. & Duncan, R. R., 2014, In : Nature Communications. 5, 5774.

Research output: Contribution to journalArticle

Open Access
File
Exocytosis
Synapses
SNARE Proteins
Munc18 Proteins
Synaptic Vesicles

Chapter 6: Primary Production, Cycling of Nutrients, Surface Layer and Plankton

Malone, T., Azzaro, M., Bode, A., Brown, E. R., Duce, R., Kamykowski, D., Sung-Ho, K., Kedong, Y., Thorndyke, M., Wang, J., Park, C., Calumpong, H. & Eghtesadi Araghi, P., 23 Dec 2015, First Global Integrated Marine Assessment, also known as the first World Ocean Assessment: World Ocean Assessment I. United Nations, 67 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Activities 2008 2016

European Commission (External organisation)

Euan R Brown (Member)
1 Jun 201619 Jul 2016

Activity: MembershipMembership of peer review panel

UN Division for Ocean Affairs and the Law of the Sea (External organisation)

Euan R Brown (Member)
23 Dec 2015

Activity: MembershipMembership of committee

Explorathon'15

Euan R Brown (Speaker)
3 Sep 2015

Activity: Participating in or organising an eventParticipation in Festival or Exhibition

European Commission (External organisation)

Euan R Brown (Member)
11 Nov 201511 Dec 2015

Activity: MembershipMembership of peer review panel

Frontiers in Cellular Neuroscience (Journal)

Euan R Brown (Editorial board member)
1 Jun 2013 → …

Activity: Publication peer-review and editorial workEditorial activity