If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Euan Brown works in the interface between Biomedical Science and Biophysics with particular emphasis on bioelectricity.  His current interests are focused on membrane ion channels which are nanoscale molecular machines (proteins) that permit membrane based signals such as secretion, neurotransmission and electrical conduction to occur.  Native and abiotic ion channels have great potential in the field of bioengineering and drug discovery.

Current Projects

Ligand and voltage-gated ion channels as sensors

Current projects involve the use of heterologously expressed hERG (human Ether-à-go-go-Related Gene product) cardiac (Kv 11.1) K+ channels in a medium throughput system for substance screening. This channel is key in stabilizing the regularity of heart beats. Drugs or substances that act on hERG have potential cardio- active properties. We are currently screening compounds on biomembranes such as bioactive fractions from marine sponges and nanomaterials. We will be developing microfluidic devices to solve drug concentration problems where the behaviour of substances in solution is dynamic (e.g Nanomedicines).

Role of voltage gated Calcium channels in excitability.

Many endocrine and neuronal cell classes are ‘spontaneously’ electrically active.  In this project we are examining the role of  voltage gated calcium channels (VGCC).   We are studying the  rules governing  the spatial- temporal organization of calcium channels in relation to other intracellular proteins to  understand how this behaviour develops and  is maintained.  These mechanisms can only be understood by combining high resolution imaging and advanced biophysical measurement of whole- cell and single calcium channel activity. We are developing the technology to couple TIRFM imaging and electrophysiology of calcium channels in muscle and synaptic zones. The results will have an impact on understanding the role of calcium channels in both health and disease and will push forward the associated technology.

A microfluidic chip for  MS research (funded by Medical Research Scotland and Epigem Ltd).

In collaboration with Epigem Ltd, we are developing a neuronal chip with built- in electrical stimulation and measurement to study the excitability changes that occur in Multiple Sclerosis (MS).  The project involve combining culture of human stem cells, multi-electrode arrays and microfluidic technology.  

Keywords

  • QP Physiology
  • biophysics
  • Physiology
  • neuroscience
  • nanomaterials
  • QL Zoology

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Ciona intestinalis Medicine & Life Sciences
Urochordata Medicine & Life Sciences
Vertebrates Medicine & Life Sciences
Larva Medicine & Life Sciences
Ion Channels Medicine & Life Sciences
Synaptic Transmission Medicine & Life Sciences
Chordata Medicine & Life Sciences
Nonvertebrate Chordata Medicine & Life Sciences

Co Author Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Selected Research Output 2000 2018

  • 32 Article
  • 1 Chapter (peer-reviewed)
  • 1 Meeting abstract

Mechanism of neutrophil activation and toxicity elicited by engineered nanomaterials

Johnston, H. J., Brown, D. M., Kanase, N., Euston, M., Gaiser, B. K., Robb, C. T., Dyrynda, E., Rossi, A. G., Brown, E. R. & Stone, V., Aug 2015, In : Toxicology in Vitro. 29, 5, p. 1172-1184 13 p.

Research output: Contribution to journalArticle

nanomaterials
Neutrophil Activation
Nanostructures
Nanostructured materials
Toxicity

Class I PI 3-kinases: Function and evolution

Kriplani, N., Hermida Ayala, M., Brown, E. R. & Leslie, N. R., Sep 2015, In : Advances in Biological Regulation. 59, p. 53-64 12 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphatidylinositol 3-Kinases
Amoebozoa
Carrier Proteins
1-Phosphatidylinositol 4-Kinase
Cell Surface Receptors

Chapter 6: Primary Production, Cycling of Nutrients, Surface Layer and Plankton

Malone, T., Azzaro, M., Bode, A., Brown, E. R., Duce, R., Kamykowski, D., Sung-Ho, K., Kedong, Y., Thorndyke, M., Wang, J., Park, C., Calumpong, H. & Eghtesadi Araghi, P., 23 Dec 2015, First Global Integrated Marine Assessment, also known as the first World Ocean Assessment: World Ocean Assessment I. United Nations, 67 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Evidence for dynamic and multiple roles for huntingtin in Ciona intestinalis

Idris, M. M., Thorndyke, M. C. & Brown, E. R., 2013, In : Invertebrate Neuroscience. 13, 2, p. 151-165 15 p.

Research output: Contribution to journalArticle

File
Ciona intestinalis
Mesoderm
Proteins
Larva
Nonvertebrate Chordata

Synaptic plasticity in cephalopods; more than just learning and memory?

Brown, E. R. & Piscopo, S., Jun 2013, In : Invertebrate Neuroscience. 13, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

Cephalopoda
Neuronal Plasticity
Learning
Insects
Vertebrates

Highly conserved elements discovered in vertebrates are present in non-syntenic loci of tunicates, act as enhancers and can be transcribed during development

Sanges, R., Hadzhiev, Y., Gueroult-Bellone, M., Roure, A., Ferg, M., Meola, N., Amore, G., Basu, S., Brown, E. R., De Simone, M., Petrera, F., Licastro, D., Strahle, U., Banfi, S., Lemaire, P., Birney, E., Muller, F. & Stupka, E., Apr 2013, In : Nucleic Acids Research. 41, 6, p. 3600-3618 19 p., 1

Research output: Contribution to journalArticle

Open Access
File
Urochordata
Vertebrates
Genome
Chordata
Gene Transfer Techniques

Monoaminergic modulation of photoreception in ascidian: evidence for a proto-hypothalamo-retinal territory

Razy-Krajka, F., Brown, E. R., Horie, T., Callebert, J., Sasakura, Y., Joly, J-S., Kusakabe, T. G. & Vernier, P., 19 May 2012, In : BMC Biology. 10, n/a, 14 p., 45

Research output: Contribution to journalArticle

Open Access
File
Urochordata
Vertebrates
Dopamine
Retina
Amacrine Cells

Ion channels in key marine invertebrates; their diversity and potential for applications in biotechnology

Brown, E. R. & Piscopo, S., 2011, In : Biotechnology Advances. 29, 5, p. 457-467 11 p.

Research output: Contribution to journalArticle

Invertebrates
Biotechnology
Ion Channels
Vertebrates
Ligand-Gated Ion Channels

A glycine receptor is involved in the organization of swimming movements in an invertebrate chordate

Nishino, A., Okamura, Y., Piscopo, S. & Brown, E. R., 19 Jan 2010, In : BMC Neuroscience. 11, n/a, 6

Research output: Contribution to journalArticle

Nonvertebrate Chordata
Glycine Receptors
Locomotion
Vertebrates
Ciona intestinalis

Nitric oxide mediates the glutamate-dependent pathway for neurotransmission in Sepia officinalis chromatophore organs

Mattiello, T., Fiore, G., Brown, E. R., d'Ischia, M. & Palumbo, A., 2010, In : Journal of Biological Chemistry. 285, 31, p. 24154-63 10 p.

Research output: Contribution to journalArticle

Sepia
Chromatophores
Synaptic Transmission
Glutamic Acid
Nitric Oxide

Natural variation of model mutant phenotypes in Ciona intestinalis

Sordino, P. , Andreakis, N. , Brown, E. R. , Leccia, N. I. , Squarzoni, P. , Tarallo, R. , Alfano, C. , Caputi, L. , D'Ambrosio, P. , Daniele, P. , D'Aniello, E. , D'Aniello, S. , Maiella, S. , Miraglia, V. , Russo, M. T. , Sorrenti, G. , Branno, M. , Cariello, L. , Cirino, P. , Locascio, A. & 3 others Spagnuolo, A., Zanetti, L. & Ristoratore, F., 2008, In : PLoS ONE. 3, 6, e2344

Research output: Contribution to journalArticle

Open Access
File
Ciona intestinalis
Chordata
Urochordata
Phenotype
Population Genetics

Morphology of antennular sensors in Clausocalanus furcatus (Copepoda : Calanoida)

Uttieri, M., Brown, E. R., Boxshall, G. A. & Mazzocchii, M. G., May 2008, In : Journal of the Marine Biological Association of the United Kingdom. 88, 3, p. 535-541 7 p.

Research output: Contribution to journalArticle

Pre- and postsynaptic excitation and inhibition at octopus optic lobe photoreceptor terminals; implications for the function of the 'presynaptic bags'

Piscopo, S., Moccia, F., Di Cristo, C., Caputi, L., Di Cosmo, A. & Brown, E. R., 2007, In : European Journal of Neuroscience. 26, 8, p. 2196-203 8 p.

Research output: Contribution to journalArticle

Octopodiformes
Tubocurarine
Synaptic Potentials
Glutamate Receptors
Staining and Labeling

Primary cultures of nervous system cells from the larva of the ascidian Ciona intestinalis

Zanetti, L., Ristoratore, F., Francone, M., Piscopo, S. & Brown, E. R., 30 Sep 2007, In : Journal of Neuroscience Methods. 165, 2, p. 191-197 7 p.

Research output: Contribution to journalArticle

Ciona intestinalis
Urochordata
Nervous System
Larva
Primary Cell Culture

Modulation of an AMPA-like glutamate receptor (SqGluR) gating by L- and D-aspartic acids

Brown, E. R., Piscopo, S., Chun, J. T., Francone, M., Mirabile, I. & D'Aniello, A., 1 Jan 2007, In : Amino Acids. 32, 1, p. 53-57 5 p.

Research output: Contribution to journalArticle

Ammonium channel expression is essential for brain development and function in the larva of Ciona intestinalis

Marino, R., Melillo, D., Di Filippo, M., Yamada, A., Pinto, M. R., De Santis, R., Brown, E. R. & Matassi, G., 1 Jul 2007, In : Journal of Comparative Neurology. 503, 1, p. 135-147 13 p.

Research output: Contribution to journalArticle

Ciona intestinalis
Ammonium Compounds
Larva
Brain
Otolithic Membrane

Brain and behavioural evidence for rest-activity cycles in Octopus vulgaris

Brown, E. R., Piscopo, S., De Stefano, R. & Giuditta, A., 25 Sep 2006, In : Behavioural Brain Research. 172, 2, p. 355-359 5 p.

Research output: Contribution to journalArticle

The genome of the sea urchin Strongylocentrotus purpuratus

Sodergren, E. , Weinstock, G. M. , Davidson, E. H. , Cameron, R. A. , Gibbs, R. A. , Angerer, R. C. , Angerer, L. M. , Arnone, M. I. , Burgess, D. R. , Burke, R. D. , Coffman, J. A. , Dean, M. , Elphick, M. R. , Ettensohn, C. A. , Foltz, K. R. , Hamdoun, A. , Hynes, R. O. , Klein, W. H. , Marzluff, W. , McClay, D. R. & 31 others Morris, R. L., Mushegian, A., Rast, J. P., Smith, L. C., Thorndyke, M. C., Vacquier, V. D., Wessel, G. M., Wray, G., Zhang, L., Elsik, C. G., Ermolaeva, O., Hlavina, W., Hofmann, G., Kitts, P., Landrum, M. J., Mackey, A. J., Maglott, D., Panopoulou, G., Poustka, A. J., Pruitt, K., Sapojnikov, V., Song, X., Souvorov, A., Solovyev, V., Wei, Z., Whittaker, C. A., Worley, K., Durbin, K. J., Shen, Y., Brown, E. R. & Sea Urchin Genome Sequencing Consortium, 10 Nov 2006, In : Science. 314, 5801, p. 941-952 12 p.

Research output: Contribution to journalArticle

The ascidian homolog of the vertebrate homeobox gene Rx is essential for ocellus development and function

D'Aniello, S., D'Aniello, E., Locascio, A., Memoli, A., Corrado, M., Russo, M. T., Aniello, F., Fucci, L., Brown, E. R. & Branno, M., Jun 2006, In : Differentiation. 74, 5, p. 222-234 13 p.

Research output: Contribution to journalArticle

Development of swimming behaviour in the larva of the ascidian Ciona intestinalis

Zega, G., Thorndyke, M. C. & Brown, E. R., Sep 2006, In : Journal of Experimental Biology. 209, 17, p. 3405-3412 8 p.

Research output: Contribution to journalArticle

D-aspartic acid in the nervous system of Aplysia limacina: possible role in neurotransmission

Spinelli, P., Brown, E. R., Ferrandino, G., Branno, M., Montarolo, P. G., D'Aniello, E., Rastogi, R. K., D'Aniello, B., Baccari, G. C., Fisher, G. & D'Aniello, A., Mar 2006, In : Journal of Cellular Physiology. 206, 3, p. 672-681 10 p.

Research output: Contribution to journalArticle

Alteration and recovery of appetitive behaviour following nerve section in the starfish Asterias rubens

Piscopo, S., De Stefano, R., Thorndyke, M. C. & Brown, E. R., 14 Oct 2005, In : Behavioural Brain Research. 164, 1, p. 36-41 6 p.

Research output: Contribution to journalArticle

Functional recovery of locomotion in denervated starfish (Asterias rubens)

Piscopo, S., De Stefano, R., Thorndyke, M. C. & Brown, E. R., Jul 2005, In : Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology. 141, 3, p. S123 1 p.

Research output: Contribution to journalMeeting abstract

GABAergic synaptic transmission modulates swimming in the ascidian larva

Brown, E. R., Nishino, A., Bone, Q., Meinertzhagen, I. A. & Okamura, Y., Nov 2005, In : European Journal of Neuroscience. 22, 10, p. 2541-2548 8 p.

Research output: Contribution to journalArticle

Ca2+ signalling and membrane current activated by cADPr in starfish oocytes

Moccia, F., Nusco, G. A., Lim, D., Ercolano, E., Gragnaniello, G., Brown, E. R. & Santella, L., 1 Aug 2003, In : Pflügers Archiv European Journal of Physiology. 446, 5, p. 541-552 12 p.

Research output: Contribution to journalArticle

A learning and memory area in the octopus brain manifests a vertebrate-like long-term potentiation

Hochner, B., Brown, E. R., Langella, M., Shomrat, T. & Fiorito, G., 1 Nov 2003, In : Journal of Neurophysiology. 90, 5, p. 3547-3554 8 p.

Research output: Contribution to journalArticle

Effect of glycine on synaptic transmission at the third order giant synapse of the squids Alloteuthis subulata and Loligo vulgaris

Vinogradova, I. M., Zajicek, J., Gentile, S. & Brown, E. R., 31 May 2002, In : Neuroscience letters. 325, 1, p. 42-46 5 p.

Research output: Contribution to journalArticle

Ionic currents in isolated and in situ squid Schwann cells

Inoue, I., Tsutsui, I., Abbott, N. J. & Brown, E. R., 15 Jun 2002, In : Journal of Physiology. 541, 3, p. 769-778 10 p.

Research output: Contribution to journalArticle

Ca2+ dynamics in synaptosomes isolated from the squid optic lobe

Benech, J. C., Lima, P. A., Sotelo, J. R. & Brown, E. R., 15 Dec 2000, In : Journal of Neuroscience Research. 62, 6, p. 840-846 7 p.

Research output: Contribution to journalArticle

Activities 2008 2016

European Commission (External organisation)

Brown, E. R. (Member)
1 Jun 201619 Jul 2016

Activity: MembershipMembership of peer review panel

UN Division for Ocean Affairs and the Law of the Sea (External organisation)

Brown, E. R. (Member)
23 Dec 2015

Activity: MembershipMembership of committee

Explorathon'15

Brown, E. R. (Speaker)
3 Sep 2015

Activity: Participating in or organising an eventParticipation in Festival or Exhibition

European Commission (External organisation)

Brown, E. R. (Member)
11 Nov 201511 Dec 2015

Activity: MembershipMembership of peer review panel

Frontiers in Cellular Neuroscience (Journal)

Brown, E. R. (Editorial board member)
1 Jun 2013 → …

Activity: Publication peer-review and editorial workEditorial activity