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Research Output 1990 2019

2019

Application of HPLC–PDA–MS metabolite profiling to investigate the effect of growth temperature and day length on blackcurrant fruit

Allwood, J. W., Woznicki, T. L., Xu, Y., Foito, A., Aaby, K., Sungurtas, J., Freitag, S., Goodacre, R., Stewart, D., Remberg, S. F., Heide, O. M. & Sønsteby, A., Jan 2019, In : Metabolomics. 15, 1, 12.

Research output: Contribution to journalArticle

Open Access
File
Growth temperature
Metabolites
Fruits
Spectrometry
Fruit

Berry-Enriched Diet in Salt-Sensitive Hypertensive Rats: Metabolic Fate of (Poly)Phenols and the Role of Gut Microbiota

Gomes, A., Oudot, C., Macià, A., Foito, A., Carregosa, D., Stewart, D., Van de Wiele, T., Berry, D., Motilva, M-J., Brenner, C. & Dos Santos, C. N., 3 Nov 2019, In : Nutrients. 11, 11, 2634.

Research output: Contribution to journalArticle

Open Access
File
Phenols
Fruit
Salts
Diet
Microbiota

Engineering Lactococcus lactis for the production of unusual anthocyanins using tea as substrate

Solopova, A., van Tilburg, A. Y., Foito, A., Allwood, J. W., Stewart, D., Kulakauskas, S. & Kuipers, O. P., Jul 2019, In : Metabolic Engineering. 54, p. 160-169 10 p.

Research output: Contribution to journalArticle

Lactococcus lactis
Anthocyanins
Tea
delphinidin
Food Industry

Identification and Microbial Production of the Raspberry Phenol Salidroside that Is Active against Huntington’s Disease

Kallscheuer, N., Menezes, R., Foito, A., Da Silva, M. H., Braga, A., Dekker, W., Sevillano, D. M., Rosado-Ramos, R., Jardim, C., Oliveira, J., Ferreira, P., Rocha, I., Silva, A. R., Sousa, M., Allwood, J. W., Bott, M., Faria, N., Stewart, D., Ottens, M., Naesby, M. & 2 others, Dos Santos, C. N. & Marienhagen, J., Mar 2019, In : Plant Physiology. 179, 3, p. 969-985 17 p.

Research output: Contribution to journalArticle

Huntington Disease
raspberries
Phenol
phenol
small fruits

Rapid UHPLC-MS metabolite profiling and phenotypic assays reveal genotypic impacts of nitrogen supplementation in oats

Allwood, J. W., Xu, Y., Martinez-Martin, P., Palau, R., Cowan, A., Goodacre, R., Marshall, A., Stewart, D. & Howarth, C., Mar 2019, In : Metabolomics. 15, 3, 42.

Research output: Contribution to journalArticle

Open Access
File
High performance liquid chromatography
Metabolites
Mass spectrometry
Assays
Mass Spectrometry
2018

(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis

Macedo, D., Jardim, C., Figueira, I., Almeida, A. F., McDougall, G. J., Stewart, D., Yuste, J. E., Tomás-Barberán, F. A., Tenreiro, S., Outeiro, T. F. & Santos, C. N., 3 May 2018, In : Scientific Reports. 8, 6965.

Research output: Contribution to journalArticle

Open Access
File
alpha-Synuclein
Phenol
Phenols
Parkinson Disease
Digestion

Extracts from the edible seaweed, Ascophyllum nodosum, inhibit lipase activity in vitro: contributions of phenolic and polysaccharide components

Austin, C., Stewart, D., Allwood, J. W. & McDougall, G. J., 1 Jan 2018, In : Food and Function. 9, 1, p. 502-510 9 p.

Research output: Contribution to journalArticle

Ascophyllum
Ascophyllum nodosum
edible seaweed
Seaweed
Lipase

Impact of Conventional and Integrated Management Systems on the Water-Soluble Vitamin Content in Potatoes, Field Beans, and Cereals

Freitag, S., Verrall, S. R., Pont, S. D. A., McRae, D., Sungurtas, J. A., Palau, R., Hawes, C., Alexander, C. J., Allwood, J. W., Foito, A., Stewart, D. & Shepherd, L. V. T., 31 Jan 2018, In : Journal of Agricultural and Food Chemistry. 66, 4, p. 831-841 11 p.

Research output: Contribution to journalArticle

water-soluble vitamins
vitamin content
Solanum tuberosum
Vitamins
Crops

Metabolomics: A high-throughput screen for biochemical and bioactivity diversity in plants and crops

Foito, A. & Stewart, D., 2018, In : Current Pharmaceutical Design. 24, 19, p. 2043-2054 12 p.

Research output: Contribution to journalReview article

Open Access
File
Metabolomics
Drug Discovery
Biological Products
Modern 1601-history
Pharmacopoeias

Metformin selectively targets redox control of complex I energy transduction

Cameron, A. R., Logie, L., Patel, K., Erhardt, S., Bacon, S., Middleton, P., Harthill, J., Forteath, C., Coats, J. T., Kerr, C., Curry, H., Stewart, D., Sakamoto, K., Repiščák, P., Paterson, M. J., Hassinen, I., McDougall, G. J. & Rena, G., 2018, In : Redox Biology. 14, p. 187-197 11 p.

Research output: Contribution to journalArticle

Open Access
File
Metformin
Oxidation-Reduction
NAD
Phenformin
Biguanides

Phytochemical Composition and Cytotoxic Effects on Liver Hepatocellular Carcinoma Cells of Different Berries Following a Simulated In Vitro Gastrointestinal Digestion

Giampieri, F., Afrin, S., Stewart, D., McDougall, G. J., Brennan, R., Blyth, L., Gasparrini, M., Mazzoni, L., Capocasa, F., Alvarez-Suarez, J. M., Bompadre, S., Nogueira Brás de Oliveira, P., N. Santos, C., Masias, M., Agudo, P., Crespo, J., Mezzetti, B., Forbes-Hernández, T. Y. & Battino, M., 1 Aug 2018, In : Molecules. 23, 8, 1918.

Research output: Contribution to journalArticle

Open Access
File
Phytochemicals
Digestion
Hepatocellular Carcinoma
Fruit
Liver

Polyphenols as new leads in drug discovery: Biological activity and mechanisms

Dos Santos, C. N., Menezes, R. & Stewart, D., 2018, In : Current Pharmaceutical Design. 24, 19, p. 2041-2042 2 p.

Research output: Contribution to journalEditorial

Open Access
File
2017

(Poly)phenol metabolites from Arbutus unedo leaves protect yeast from oxidative injury by activation of antioxidant and protein clearance pathways

Jardim, C., Macedo, D., Figueira, I., Dobson, G., McDougall, G. J., Stewart, D., Ferreira, R. B., Menezes, R. & Santos, C. N., May 2017, In : Journal of Functional Foods. 32, p. 333-346 14 p.

Research output: Contribution to journalArticle

Arbutus unedo
Phenol
phenol
Antioxidants
Yeasts

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Dudnik, A., Almeida, A. F., Andrade, R., Avila, B., Bañados, P., Barbay, D., Bassard, J. E., Benkoulouche, M., Bott, M., Braga, A., Breitel, D., Brennan, R., Bulteau, L., Chanforan, C., Costa, I., Costa, R. S., Doostmohammadi, M., Faria, N., Feng, C., Fernandes, A. & 63 others, Ferreira, P., Ferro, R., Foito, A., Freitag, S., Garcia, G., Gaspar, P., Godinho-Pereira, J., Hamberger, B., Hartmann, A., Heider, H., Jardim, C., Julien-Laferriere, A., Kallscheuer, N., Kerbe, W., Kuipers, O. P., Li, S., Love, N., Marchetti-Spaccamela, A., Marienhagen, J., Martin, C., Mary, A., Mazurek, V., Meinhart, C., Sevillano, D. M., Menezes, R., Naesby, M., Nørholm, M. H. H., Okkels, F. T., Oliveira, J., Ottens, M., Parrot, D., Pei, L., Rocha, I., Rosado-Ramos, R., Rousseau, C., Sagot, M. F., Dos Santos, C. N., Schmidt, M., Shelenga, T., Shepherd, L., Silva, A. R., da Silva, M. H., Simon, O., Stahlhut, S. G., Solopova, A., Sorokin, A., Stewart, D., Stougie, L., Su, S., Thole, V., Tikhonova, O., Trick, M., Vain, P., Veríssimo, A., Vila-Santa, A., Vinga, S., Vogt, M., Wang, L., Wang, L., Wei, W., Youssef, S., Neves, A. R. & Forster, J., 8 Sep 2017, In : Phytochemistry Reviews. p. 1-36 36 p.

Research output: Contribution to journalArticle

Open Access
File
small fruits
phenolic compounds
Fruit
fruits
commercialization

Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation

Garcia, G., Nanni, S., Figueira, I., Ivanov, I., Mcdougall, G. J., Stewart, D., Ferreira, R. B., Pinto, P., Silva, R. F. M., Brites, D. & Santos, C. N., 15 Jan 2017, In : Food Chemistry. 215, p. 274–283 10 p.

Research output: Contribution to journalArticle

Microglia
Phenol
Oxidative Stress
Lipopolysaccharides
Polyphenols

Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response?

Goszcz, K., Duthie, G. G., Stewart, D., Leslie, S. J. & Megson, I. L., Jun 2017, In : British Journal of Pharmacology. 174, 11, p. 1209-1225 17 p.

Research output: Contribution to journalReview article

Open Access
File
Polyphenols
Xenobiotics
Cardiovascular Diseases
Antioxidants
Pharmacology
Open Access
File
delphinidin
Gallic Acid
Endothelial cells
Metabolites
Glutathione

Blood–brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study

Figueira, I., Tavares, L., Jardim, C., Costa, I., Terrasso, A. P., Almeida, A. F., Govers, C., Mes, J. J., Gardner, R., Becker, J. D., McDougall, G. J., Stewart, D., Filipe, A., Kim, K. S., Brites, D., Brito, C., Brito, M. A. & Santos, C. N., 18 Nov 2017, In : European Journal of Nutrition. p. 1-18 18 p.

Research output: Contribution to journalArticle

Polyphenols
In Vitro Techniques
Rubus
Neuroprotective Agents
Neurodegenerative Diseases

Polyphenols journey through blood-brain barrier towards neuronal protection

Figueira, I., Garcia, G., Pimpão, R. C., Terrasso, A. P., Costa, I., Almeida, A. F., Tavares, L., Pais, T. F., Pinto, P., Ventura, M. R., Filipe, A., McDougall, G. J., Stewart, D., Kim, K. S., Palmela, I., Brites, D., Brito, M. A., Brito, C. & Santos, C. N., 13 Sep 2017, In : Scientific Reports. 7, 11456.

Research output: Contribution to journalArticle

Open Access
File
Polyphenols
Blood-Brain Barrier
Sulfates
Neurodegenerative Diseases
Phenols

Quantitative trait loci associated with different polar metabolites in perennial ryegrass - providing scope for breeding towards increasing certain polar metabolites

Foito, A., Hackett, C. A., Stewart, D., Velmurugan, J., Milbourne, D., Byrne, S. L. & Barth, S., 10 Oct 2017, In : BMC Genetics. 18, 84.

Research output: Contribution to journalArticle

Open Access
File
Lolium
Quantitative Trait Loci
Breeding
Single Nucleotide Polymorphism
Sugar Acids
2016

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug

Cameron, A. R., Logie, L., Patel, K., Bacon, S., Forteath, C., Harthill, J., Roberts, A., Sutherland, C., Stewart, D., Viollet, B., Sakamoto, K., McDougall, G. J., Foretz, M. & Rena, G., 1 Aug 2016, In : BBA Molecular Basis of Disease. 1862, 8, p. 1412-1422 11 p.

Research output: Contribution to journalArticle

Open Access
File
Salicylates
Liver
Pharmaceutical Preparations
AMP-Activated Protein Kinases
Hydroxybenzoates

Lingonberries (Vaccinium vitis-idaea L) and blueberries (Vaccinium corymbosum) contain discrete epicatechin anthocyanin derivatives linked by ethyl bridges

Brown, E. M., Gill, C. I. R., Stewart, D. & McDougall, G. J., 11 Mar 2016, In : Journal of Berry Research. 6, 1, p. 13-23 11 p.

Research output: Contribution to journalArticle

Vaccinium vitis-idaea
Blueberry Plants
Vaccinium corymbosum
Anthocyanins
Catechin

Nontargeted LC-MSn profiling of compounds in ileal fluids that decrease after raspberry intake identifies consistent alterations in bile acid composition

McDougall, G. J., Allwood, J. W., Pereira-Caro, G., Brown, E. M., Ternan, N., Verrall, S., Stewart, D., Lawther, R., O'Connor, G., Rowland, I., Crozier, A. & Gill, C. I. R., 28 Oct 2016, In : Journal of Natural Products. 79, 10, p. 2606-2615 10 p.

Research output: Contribution to journalArticle

Metabolites
Bile Acids and Salts
Cholates
Deconvolution
Fluids

Nutritional and Phytochemical Content of High-Protein Crops

Multari, S., Neacsu, M., Scobbie, L., Cantlay, L., Duncan, G., Vaughan, N., Stewart, D. & Russell, W. R., 19 Oct 2016, In : Journal of Agricultural and Food Chemistry. 64, 41, p. 7800-7811 12 p.

Research output: Contribution to journalArticle

Open Access
File
Phytochemicals
Fagopyrum
phytopharmaceuticals
Crops
Vicia faba
2015

(Poly)phenols protect from alpha-synuclein toxicity by reducing oxidative stress and promoting autophagy

Macedo, D., Tavares, L., McDougall, G. J., Miranda, H. V., Stewart, D., Ferreira, R. B., Tenreiro, S., Outeiro, T. F. & Santos, C. N., 15 Mar 2015, In : Human Molecular Genetics. 24, 6, p. 1717-1732 16 p.

Research output: Contribution to journalArticle

Modifying glycoalkaloid content in transgenic potato - Metabolome impacts

Shepherd, L. V. T., Hackett, C. A., Alexander, C. J., McNicol, J. W., Sungurtas, J. A., Stewart, D., McCue, K. F., Belknap, W. R. & Davies, H. V., 15 Nov 2015, In : Food Chemistry. 187, p. 437-443 7 p.

Research output: Contribution to journalArticle

metabolome
glycoalkaloids
Metabolome
Solanum tuberosum
Liquid Chromatography

Phenolic compounds in blackcurrant (Ribes nigrum L.) leaves relative to leaf position and harvest date

Vagiri, M., Conner, S., Stewart, D., Andersson, S. C., Verrall, S., Johansson, E. & Rumpunen, K., 1 Apr 2015, In : Food Chemistry. 172, p. 135-142 8 p.

Research output: Contribution to journalArticle

Ribes
Ribes nigrum
black currants
Glucosides
harvest date
2014

Effect of agricultural production systems on the potato metabolome

Shepherd, L. V. T., Hackett, C. A., Alexander, C. J., Sungurtas, J., Pont, S. D. A., Stewart, D., McNicol, J. W., Wilcockson, S. J., Leifert, C. & Davies, H. V., Apr 2014, In : Metabolomics. 10, 2, p. 212-224 13 p.

Research output: Contribution to journalArticle

metabolome
production technology
potatoes
organic fertilizers
metabolites

Relationship between volatile profile and sensory development of an oat-based biscuit

Cognat, C., Shepherd, T., Verrall, S. R. & Stewart, D., 1 Oct 2014, In : Food Chemistry. 160, p. 72-81 10 p.

Research output: Contribution to journalArticle

oat cakes
biscuits
Flavors
oats
Antioxidants

Tracking (poly)phenol components from raspberries in ileal fluid

Mcdougall, G. J., Conner, S., Pereira-Caro, G., Gonzalez-Barrio, R., Brown, E. M., Verrall, S., Stewart, D., Moffet, T., Ibars, M., Lawther, R., O'Connor, G., Rowland, I., Crozier, A. & Gill, C. I. R., 7 Jul 2014, In : Journal of Agricultural and Food Chemistry. 62, 30, p. 7631-7641 11 p.

Research output: Contribution to journalArticle

raspberries
Metabolites
Phenol
phenol
Anthocyanins
2013

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease

Vepsäläinen, S., Koivisto, H., Pekkarinen, E., Mäkinen, P., Dobson, G., McDougall, G. J., Stewart, D., Haapasalo, A., Karjalainen, R. O., Tanila, H. & Hiltunen, M., Jan 2013, In : The Journal of Nutritional Biochemistry. 24, 1, p. 360-370 11 p.

Research output: Contribution to journalArticle

Vaccinium myrtillus
Anthocyanins
Amyloid beta-Protein Precursor
Alzheimer Disease
Diet

Elucidating phytochemical production in Juniperus sp. seasonality and response to stress situations

Tavares, L. R., Pimpão, R. C., McDougall, G. J., Stewart, D., Ferreira, R. B. & Santos, C. N., 1 May 2013, In : Journal of Agricultural and Food Chemistry. 61, 17, p. 4044-4052 9 p.

Research output: Contribution to journalArticle

Lingonberries retain bioactivity following simulated gastrointestinal digestion and colonic fermentation

Gill, C. E., Brown, E. M., McDougall, G. J., Stewart, D., Pereira-Caro, G., Allsopp, P., Crozier, A. & Rowland, I. R., 2013, In : Annals of Nutrition and Metabolism. 63, Supplement 1, p. 1704 1 p.

Research output: Contribution to journalMeeting abstract

Mechanisms underlying chemopreventive effects of flavonoids via multiple signaling nodes within Nrf2-ARE and AhR-XRE gene regulatory networks

Xiao, H., Lü, F., Stewart, D. & Zhang, Y., 29 Nov 2013, In : Current Chemical Biology. 7, 2, p. 151-176 26 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Detoxification
Flavonoids
Genes
Carcinogens

Mechanisms Underlying Chemopreventive Effects of Flavonoids via Multiple Signaling Nodes within Nrf2-ARE and AhR-XRE Gene Regulatory Networks

Xiao, H., Lü, F., Stewart, D. & Zhang, Y., 2013, In : Current Chemical Biology. 7, 2, p. 151-176 26 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Flavonoids
Carcinogens
Genes
Antioxidants

Neuroprotective effects of digested polyphenols from wild blackberry species

Tavares, L. R., Figueira, I., McDougall, G. J., Vieira, H. L. A., Stewart, D., Alves, P. M., Ferreira, R. B. & Santos, C. N., 2013, In : European Journal of Nutrition. 52, 1, p. 225-236

Research output: Contribution to journalArticle

Polyphenols
Neuroprotective Agents
Caspases
Cell Death
Oxidation-Reduction

Safety assessment of GM crops: Metabolomics in Food and Nutrition

Stewart, D. & Shepherd, L. V. T., Oct 2013, Metabolomics in Food and Nutrition. Weimer, B. C. (ed.). Cambridge: Woodhead Publishing Ltd.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sequential extraction of black currant residues produce anthocyanin-rich extracts containing anthocyanin dimers

Juedtz, K., Aberdein, N., Stewart, D. & McDougall, G. J., 2013, In : Journal of Berry Research. 3, 1, p. 53-64

Research output: Contribution to journalArticle

black currants
anthocyanins
pomace
polyphenols
extracts
2012

Antioxidant capacity, total phenolic and ascorbate content as a function of the genetic diversity of leek (Allium ampeloprasum var. porrum)

Bernaert, N., De Paepe, D., Bouten, C., Declercq, H., Stewart, D., Van Bockstaele, E., De Loose, M. & Van Droogenbroeck, B., 2012, In : Food Chemistry. 134, 2, p. 669-677 9 p.

Research output: Contribution to journalArticle

Berry components inhibit α-glucosidase in vitro: synergies between acarbose and polyphenols from black currant and rowanberry

Boath, A. S., Stewart, D. & McDougall, G. J., Dec 2012, In : Food Chemistry. 135, 3, p. 929-936 8 p.

Research output: Contribution to journalArticle

Berry polyphenols inhibit digestive enzymes: a source of potential health benefits?

Boath, A. S., Grussu, D., Stewart, D. & McDougall, G. J., 2012, In : Food Digestion. 3, 1-3, p. 1-7 7 p.

Research output: Contribution to journalArticle

Comparison of effects of biguanide and diguanidine antidiabetic drugs on cell signalling responses

Bacon, S., Stewart, D., McDougall, G. J. & Rena, G., 2012.

Research output: Contribution to conferencePoster

Comparison of two headspace sampling techniques for the analysis of off-flavour volatiles from oat based products

Cognat, C., Shepherd, T., Verrall, S. R. & Stewart, D., Oct 2012, In : Food Chemistry. 134, 3, p. 1592-1600 9 p.

Research output: Contribution to journalArticle

Compositional and toxicological analysis of a GM potato line with reduced α-solanine content - a 90-day feeding study in the Syrian Golden hamster

Langkilde, S., Schroder, M., Frank, T., Shepherd, L. V. T., Conner, S., Davies, H. V., Meyer, O., Danier, J., Rychlik, M., Belknap, W. R., McCue, K. F., Engel, K-H., Stewart, D., Knudsen, I. & Poulsen, M., Oct 2012, In : Regulatory Toxicology and Pharmacology . 64, 1, p. 177-185 9 p.

Research output: Contribution to journalArticle

Solanine
Mesocricetus
Solanum tuberosum
Toxicology
Solanaceae

Fortification of blackcurrant juice with crowberry: impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects

Torronen, R., McDougall, G. J., Dobson, G., Stewart, D., Hellstrom, J., Mattila, P., Pihlava, J. M., Koskela, A. & Karjalainen, R. O., 2012, In : Journal of Functional Foods. 4, 4, p. 746-756 11 p.

Research output: Contribution to journalArticle

Genetic linkage mapping in an F2 perennial ryegrass population using DArT markers

Tomaszewski, C., Byrne, S. L., Foito, A., Kildea, S., Kopeckì, D., Dolezel, J., Heslop-Harrison, J. S., Stewart, D. & Barth, S., Apr 2012, In : Plant Breeding. 131, 2, p. 345-349

Research output: Contribution to journalArticle

Lolium perenne
chromosome mapping
Puccinia coronata
crown rust
forage grasses

Impact of anthocyanin-rich bilberry and blackcurrant extract on cognitive impairment in a transgenic model of Alzheimer's disease

Koivisto, H., Vepsäläinen, S., McDougall, G. J., Stewart, D., Koskela, A., Tanila, H., Hiltunen, M. & Karjalainen, R. O., 2012.

Research output: Contribution to conferencePoster

Lipophilic components in black currant seed and pomace extracts

Dobson, G., Shrestha, M., Hilz, H., Karjalainen, R., McDougall, G. & Stewart, D., May 2012, In : European Journal of Lipid Science and Technology. 114, 5, p. 575-582 8 p.

Research output: Contribution to journalArticle

Mechanisms underlying the anti-proliferative effects of berry components in in vitro models of colon cancer

Brown, E. M., Gill, C. I. R., McDougall, G. J. & Stewart, D., Jan 2012, In : Current Pharmaceutical Biotechnology. 13, 1, p. 200-209 10 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Fruit
Colorectal Neoplasms
Phytochemicals
Sorbus

Neuroprotective effect of blackberry (Rubus sp.) polyphenols is potentiated after simulated gastronintestinal digestion

Tavares, L. R., Figueira, I., Macedo, D., McDougall, G. J., Leitao, M. C., Vieira, H. L. A., Stewart, D., Alves, P. M., Ferreira, R. B. & Santos, C. N., 15 Apr 2012, In : Food Chemistry. 131, 4, p. 1443-1452 10 p.

Research output: Contribution to journalArticle

neuroprotective effect
blackberries
Rubus
polyphenols
digestion