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2019

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

Omar, F., Findlay, J. E., Carfray, G., Allcock, R. W., Jiang, Z., Moore, C., Muir, A. L., Lannoy, M., Fertig, B. A., Mai, D., Day, J. P., Bolger, G., Baillie, G. S., Schwiebert, E., Klussmann, E., Pyne, N. J., Ong, A. C. M., Bowers, K., Adam, J. M., Adams, D. R. & 2 others, Houslay, M. D. & Henderson, D. J. P., 2 Jul 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13320-13329 10 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
16 Downloads (Pure)

Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2

Adams, D. R., Tawati, S., Berretta, G., Lopez Rivas, P., Baiget, J., Jiang, Z., Alsfouk, A., Mackay, S. P., Pyne, N. & Pyne, S., 11 Apr 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3658-3676 19 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
1 Downloads (Pure)
2018

Sphingosine 1-phosphate and cancer

Pyne, N. J., El Buri, A., Adams, D. R. & Pyne, S., May 2018, In : Advances in Biological Regulation. 68, p. 97-106 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
Open Access
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12 Citations (Scopus)
38 Downloads (Pure)
2017

FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system

Yalla, K. C., Elliott, C., Day, J. P., Findlay, J., Barratt, S., Hughes, Z. A., Wilson, L., Whiteley, E., Popiolek, M., Li, Y., Dunlop, J., Killick, R., Adams, D. R., Brandon, N. J., Houslay, M. D., Hao, B. & Baillie, G. S., 20 Jul 2017, In : Molecular Psychiatry. 23, 5, p. 1278–1286 9 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
46 Downloads (Pure)

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners

Houslay, K. F., Christian, F., MacLeod, R., Adams, D. R., Houslay, M. D. & Baillie, G. S., 3 Feb 2017, In : Biochemical Journal. 474, 4, p. 597-609 13 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
58 Downloads (Pure)

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

Parnell, E., McElroy, S. P., Wiejak, J., Baillie, G. L., Porter, A., Adams, D. R., Rehmann, H., Smith, B. O. & Yarwood, S. J., 22 Mar 2017, In : Scientific Reports. 7, 294.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
50 Downloads (Pure)

Sphingosine Kinase 2 in Autoimmune/Inflammatory Disease and the Development of Sphingosine Kinase 2 Inhibitors

Pyne, N. J., Adams, D. R. & Pyne, S., Jul 2017, In : Trends in Pharmacological Sciences. 38, 7, p. 581-591

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
18 Downloads (Pure)
2016

RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells

Kiely, M., Adams, D. R., Hayes, S. L., O'Connor, R., Baillie, G. S. & Kiely, P. A., 4 Sep 2016, In : Cellular Signalling.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances

Pyne, S., Adams, D. R. & Pyne, N. J., Apr 2016, In : Progress in Lipid Research. 62, p. 93-106 14 p.

Research output: Contribution to journalArticle

Open Access
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75 Citations (Scopus)
72 Downloads (Pure)

Sphingosine Kinases: Emerging Structure-Function Insights

Adams, D. R., Pyne, S. & Pyne, N. J., May 2016, In : Trends in Biochemical Sciences. 41, 5, p. 395-409 15 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2015

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

Bolger, G. B., Dunlop, A. J., Meng, D., Day, J. P., Klussmann, E., Baillie, G. S., Adams, D. R. & Houslay, M. D., Apr 2015, In : Cellular Signalling. 27, 4, p. 756-769 14 p.

Research output: Contribution to journalArticle

Open Access
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16 Citations (Scopus)
59 Downloads (Pure)
2013

Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)

Cameron, R. T., Coleman, R. G., Day, J. P., Yalla, K. C., Houslay, M. D., Adams, D. R., Shoichet, B. K. & Baillie, G. S., 1 May 2013, In : Biochemical Pharmacology. 85, 9, p. 1297-1305 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Phosphodiesterase inhibitors. Part 5: Hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration

Ochiai, K., Takita, S., Kojima, A., Eiraku, T., Iwase, K., Kishi, T., Ohinata, A., Yageta, Y., Yasue, T., Adams, D. R. & Kohno, Y., 1 Jan 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 375-381 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
1 Downloads (Pure)
2012

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

Hudson, B. D., Christiansen, E., Tikhonova, I. G., Grundmann, M., Kostenis, E., Adams, D. R., Ulven, T. & Milligan, G., 13 Aug 2012, In : The FASEB Journal. 26, 12, p. 4951-65 15 p.

Research output: Contribution to journalArticle

Open Access
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47 Citations (Scopus)
169 Downloads (Pure)

Direct interaction between scaffolding proteins RACK1 and 14-3-3 zeta regulates brain-derived Neurotrophic Factor ( BDNF) Transcription

Neasta, J., Kiely, P. A., He, D-Y., Adams, D. R., O'Connor, R. & Ron, D., 2 Jan 2012, In : Journal of Biological Chemistry. 287, 1, p. 322-336 15 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity

Ochiai, K., Takita, S., Eiraku, T., Kojima, A., Iwase, K., Kishi, T., Fukuchi, K., Yasue, T., Adams, D. R., Allcock, R. W., Jiang, Z. & Kohno, Y., 2012, In : Bioorganic and Medicinal Chemistry. 20, 5, p. 1644-58 15 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Phosphodiesterase inhibitors. Part 4: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones

Ochiai, K., Takita, S., Kojima, A., Eiraku, T., Ando, N., Iwase, K., Kishi, T., Ohinata, A., Yageta, Y., Yasue, T., Adams, D. R. & Kohno, Y., 15 Sep 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 18, p. 5833-5838 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Serine Phosphorylation of the Insulin-like Growth Factor I (IGF-1) Receptor C-terminal Tail Restrains Kinase Activity and Cell Growth

Kelly, G. M., Buckley, D. A., Kiely, P. A., Adams, D. R. & O'Connor, R., 10 Aug 2012, In : Journal of Biological Chemistry. 287, 33, p. 28180-28194 15 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2011

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

Sin, Y. Y., Edwards, H. V., Li, X., Day, J. P., Christian, F., Dunlop, A. J., Adams, D., Zaccolo, M., Houslay, M. D. & Baillie, G. S., May 2011, In : Journal of Molecular and Cellular Cardiology. 50, 5, p. 872-883 12 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4)

Day, J. P., Lindsay, B., Riddell, T., Jiang, Z., Allcock, R. W., Abraham, A., Sookup, S., Christian, F., Bogum, J., Martin, E. K., Rae, R. L., Anthony, D., Rosair, G. M., Houslay, D. M., Huston, E., Baillie, G. S., Klussmann, E., Houslay, M. D. & Adams, D. R., 12 May 2011, In : Journal of Medicinal Chemistry. 54, 9, p. 3331-3347 17 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Extracellular Loop 2 of the Free Fatty Acid Receptor 2 Mediates Allosterism of a Phenylacetamide Ago-Allosteric Modulator

Smith, N. J., Ward, R. J., Stoddart, L. A., Hudson, B. D., Kostenis, E., Ulven, T., Morris, J. C., Traenkle, C., Tikhonova, I. G., Adams, D. R. & Milligan, G., Jul 2011, In : Molecular Pharmacology. 80, 1, p. 163-173 11 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast

Allcock, R. W., Blakli, H., Jiang, Z., Johnston, K. A., Morgan, K. M., Rosair, G. M., Iwase, K., Kohno, Y. & Adams, D. R., 1 Jun 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 11, p. 3307-3312 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Phosphodiesterase inhibitors. Part 2: Design, synthesis, and structure-activity relationships of dual PDE3/4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory and bronchodilatory activity

Ochiai, K., Ando, N., Iwase, K., Kishi, T., Fukuchi, K., Ohinata, A., Zushi, H., Yasue, T., Adams, D. R. & Kohno, Y., 15 Sep 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 18, p. 5451-5456 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2010

Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells

Burton, P., Adams, D. R., Abraham, A., Allcock, R. W., Jiang, Z., McCahill, A., Gilmour, J., McAbney, J., Kaupisch, A., Kane, N. M., Baillie, G. S., Baker, A. H., Milligan, G., Houslay, M. D. & Mountford, J. C., 15 Dec 2010, In : Biochemical Journal. 432, 3, p. 575-584 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

Andrews, P. D., Becroft, M., Aspegren, A., Gilmour, J., James, M. J., McRae, S., Kime, R., Allcock, R. W., Abraham, A., Jiang, Z., Strehl, R., Mountford, J. C., Milligan, G., Houslay, M. D., Adams, D. R. & Frearson, J. A., 2010, In : Biochemical Journal. 432, 1, p. 21-33 13 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells

Burton, P., Adams, D. R., Abraham, A., Allcock, R. W., Jiang, Z., McCahill, A., Gilmour, J., McAbney, J., Kane, N. M., Baillie, G. S., McKenzie, F. R., Baker, A. H., Houslay, M. D., Mountford, J. C. & Milligan, G., Aug 2010, In : Biochemical Society Transactions. 38, 4, p. 1058-1061 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

P62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways

Christian, F., Anthony, D. F., Vadrevu, S., Riddell, T., Day, J. P., McLeod, R., Adams, D. R., Baillie, G. S. & Houslay, M. D., Oct 2010, In : Cellular Signalling. 22, 10, p. 1576-1596 21 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Putting the lid on phosphodiesterase 4

Houslay, M. D. & Adams, D. R., Jan 2010, In : Nature Biotechnology. 28, 1, p. 38-40 3 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK

Li, X., Vadrevu, S., Dunlop, A., Day, J., Advant, N., Troeger, J., Klussmann, E., Jaffrey, E., Hay, R. T., Adams, D. R., Houslay, M. D. & Baillie, G. S., 15 May 2010, In : Biochemical Journal. 428, 1, p. 55-65 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2009

A scanning peptide array approach uncovers association sites within the JNK/βarrestin signalling complex

Li, X., MacLeod, R., Dunlop, A. J., Edwards, H. V., Advant, N., Gibson, L. C. D., Devine, N. M., Brown, K. M., Adams, D. R., Houslay, M. D. & Baillie, G. S., 20 Oct 2009, In : FEBS Letters. 583, 20, p. 3310-3316 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

MEK1 binds directly to βarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization

Meng, D., Lynch, M. J., Huston, E., Beyermann, M., Eichhorst, J., Adams, D. R., Klusmann, E., Houslay, M. D. & Baillie, G. S., 24 Apr 2009, In : Journal of Biological Chemistry. 284, 17, p. 11425-11435 11 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase

Kiely, P. A., Baillie, G. S., Barrett, R., Buckley, D. A., Adams, D. R., Houslay, M. D. & O'Connor, R., 24 Jul 2009, In : Journal of Biological Chemistry. 284, 30, p. 20263-20274 12 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)
2008

Concise routes to pyrazolo[1,5-a]pyridin-3-yl pyridazin-3-ones

Johnston, K. A., Allcock, R. W., Jiang, Z., Collier, I. D., Blakli, H., Rosair, G. M., Bailey, P. D., Morgan, K. M., Kohno, Y. & Adams, D. R., 2008, In : Organic and Biomolecular Chemistry. 6, 1, p. 175-186 12 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β2-adrenoceptor and the ERK1/2 MAPKs: Implications for β2-adrenoceptor signalling via the ERK1/2 MAPKs

Xu, T. R., Baillie, G. S., Bhari, N., Houslay, T. M., Pitt, A. M., Adams, D. R., Kolch, W., Houslay, M. D. & Milligan, G., 1 Jul 2008, In : Biochemical Journal. 413, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2007

1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, βarrestin and RACK1

Smith, K. J., Baillie, G. S., Hyde, E. I., Li, X., Houslay, T. M., McCahill, A., Dunlop, A. J., Bolger, G. B., Klussmann, E., Adams, D. R. & Houslay, M. D., Dec 2007, In : Cellular Signalling. 19, 12, p. 2612-2624 13 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: A new class of protein tyrosine phosphatase 1B inhibitors

Adams, D. R., Abraham, A., Asano, J., Breslin, C., Dick, C. A. J., Ixkes, U., Johnston, B. F., Johnston, D., Kewnay, J., Mackay, S. P., MacKenzie, S. J., McFarlane, M., Mitchell, L., Spinks, D. & Takano, Y., 1 Dec 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 23, p. 6579-6583 5 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of β-arrestin using spot-immobilized peptide arrays

Baillie, G. S., Adams, D. R., Bhari, N., Houslay, T. M., Vadrevu, S., Meng, D., Li, X., Dunlop, A., Milligan, G., Bolger, G. B., Klussmann, E. & Houslay, M. D., 15 May 2007, In : Biochemical Journal. 404, 1, p. 71-80 10 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
2006

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, β-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5

Bolger, G. B., Baillie, G. S., Li, X., Lynch, M. J., Herzyk, P., Mohamed, A., High Mitchell, L., McCahill, A., Hundsrucker, C., Klussmann, E., Adams, D. R. & Houslay, M. D., 15 Aug 2006, In : Biochemical Journal. 398, 1, p. 23-36 14 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)
2004

Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene

Johnston, L. A., Erdogan, S., Cheung, Y. F., Sullivan, M., Barber, R., Lynch, M. J., Baillie, G. S., Van Heeke, G., Adams, D. R., Huston, E. & Houslay, M. D., 1 Jun 2004, In : Biochemical Journal. 380, 2, p. 371-384 14 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2003

Biofilm-specific cross-species induction of antimicrobial compounds in bacilli

Yan, L., Boyd, K. G., Adams, D. R. & Burgess, J. G., 1 Jul 2003, In : Applied and Environmental Microbiology. 69, 7, p. 3719-3727 9 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1)

Frame, M. J., Tate, R., Adams, D. R., Morgan, K. M., Houslay, M. D., Vandenabeele, P. & Pyne, N. J., Mar 2003, In : European Journal of Biochemistry. 270, 5, p. 962-970 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Interaction of caspase-3 with the cyclic GMP binding GMP specific phosphodiesterase (PDE5a1)

Frame, M. J., Tate, R., Adams, D. R., Morgan, K. M., Houslay, M. D., Vandenabeele, P. & Pyne, N. J., 2003, In : European Journal of Biochemistry. 270, p. 962-970 9 p.

Research output: Contribution to journalArticle

Occupancy of the catalytic site of PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process

Terry, R., Cheung, Y. F., Praestegaard, M., Baillie, G. S., Huston, E., Gall, I., Adams, D. R. & Houslay, M. D., 2003, In : Cellular Signalling. 15, p. 955-971 17 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process

Terry, R., Cheung, Y. F., Praestegaard, M., Baillie, G. S., Huston, E., Gall, I., Adams, D. R. & Houslay, M. D., 1 Oct 2003, In : Cellular Signalling. 15, 10, p. 955-971 17 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

The development of a marine natural product-based antifouling paint

Burgess, J. G., Boyd, K. G., Armstrong, E., Jiang, Z., Yan, L., Berggren, M., May, U., Pisacane, T., Granmo, Å. . & Adams, D. R., Apr 2003, In : Biofouling. 19, SUPPL., p. 197-205 9 p.

Research output: Contribution to journalArticle

140 Citations (Scopus)
2002

JM47, a cyclic tetrapeptide HC-toxin analogue from a marine Fusarium species

Jiang, Z., Barret, M. O., Boyd, K. G., Adams, D. R., Boyd, A. S. F. & Grant Burgess, J., 10 May 2002, In : Phytochemistry. 60, 1, p. 33-38 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2000

Two diketopiperazines and one halogenated phenol from cultures of the marine bacterium, Pseudoaltermonas Luteoviolacea

Jiang, Z., Boyd, K. G., Mearns-Spragg, A., Adams, D. R., Wright, P. C. & Burgess, J. G., 2000, In : Natural Product Letters. 14, 6, p. 435-440 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
1999

Antibacterial and repellent activities of marine bacteria associated with algal surfaces

Boyd, K. G., Adams, D. R. & Burgess, J. G., 1 Dec 1999, In : Biofouling. 14, 3, p. 227-236

Research output: Contribution to journalArticle

77 Citations (Scopus)
1998

Heterocyclic nucleoside analogues by cycloaddition reactions of 1- vinylthymine with 1,3-dipoles

Adams, D. R., Boyd, A. S. F., Ferguson, R., Grierson, D. S. & Monneret, C., 1998, In : Nucleosides and Nucleotides. 17, 6, p. 1053-1075 23 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)