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Research Output

2019

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

Omar, F., Findlay, J. E., Carfray, G., Allcock, R. W., Jiang, Z., Moore, C., Muir, A. L., Lannoy, M., Fertig, B. A., Mai, D., Day, J. P., Bolger, G., Baillie, G. S., Schwiebert, E., Klussmann, E., Pyne, N. J., Ong, A. C. M., Bowers, K., Adam, J. M., Adams, D. R. & 2 others, Houslay, M. D. & Henderson, D. J. P., 2 Jul 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13320-13329 10 p.

Research output: Contribution to journalArticle

Open Access
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16 Downloads (Pure)

Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2

Adams, D. R., Tawati, S., Berretta, G., Lopez Rivas, P., Baiget, J., Jiang, Z., Alsfouk, A., Mackay, S. P., Pyne, N. & Pyne, S., 11 Apr 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3658-3676 19 p.

Research output: Contribution to journalArticle

Open Access
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2018

Compounds and their use as PDE4 activators

Adam, J. M. & Adams, D. R., 5 Apr 2018, IPC No. A61K31/4196, A61P1/00, A61P11/00, A61P13/00, A61P35/00, A61P5/00, A61P9/00, C07D249/08, C07D403/12, World Intellectual Property Organization (WIPO), Patent No. WO2018060704(A1), Priority date 28 Sep 2016, Priority No. GB20160016439 20160928

Research output: Patent

Open Access
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17 Downloads (Pure)

Sphingosine 1-phosphate and cancer

Pyne, N. J., El Buri, A., Adams, D. R. & Pyne, S., May 2018, In : Advances in Biological Regulation. 68, p. 97-106 10 p.

Research output: Contribution to journalArticle

Sphingosine Kinases as Druggable Targets

Pyne, S., Adams, D. R. & Pyne, N. J., 2018, Lipid Signaling in Human Diseases. Springer, p. 49-76 28 p. (Handbook of Experimental Pharmacology; vol. 259).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Open Access
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37 Downloads (Pure)
2017

FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system

Yalla, K. C., Elliott, C., Day, J. P., Findlay, J., Barratt, S., Hughes, Z. A., Wilson, L., Whiteley, E., Popiolek, M., Li, Y., Dunlop, J., Killick, R., Adams, D. R., Brandon, N. J., Houslay, M. D., Hao, B. & Baillie, G. S., 20 Jul 2017, In : Molecular Psychiatry. 23, 5, p. 1278–1286 9 p.

Research output: Contribution to journalArticle

Open Access
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46 Downloads (Pure)

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners

Houslay, K. F., Christian, F., MacLeod, R., Adams, D. R., Houslay, M. D. & Baillie, G. S., 3 Feb 2017, In : Biochemical Journal. 474, 4, p. 597-609 13 p.

Research output: Contribution to journalArticle

Open Access
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58 Downloads (Pure)

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

Parnell, E., McElroy, S. P., Wiejak, J., Baillie, G. L., Porter, A., Adams, D. R., Rehmann, H., Smith, B. O. & Yarwood, S. J., 22 Mar 2017, In : Scientific Reports. 7, 294.

Research output: Contribution to journalArticle

Open Access
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50 Downloads (Pure)

Sphingosine Kinase 2 in Autoimmune/Inflammatory Disease and the Development of Sphingosine Kinase 2 Inhibitors

Pyne, N. J., Adams, D. R. & Pyne, S., Jul 2017, In : Trends in Pharmacological Sciences. 38, 7, p. 581-591

Research output: Contribution to journalArticle

Open Access
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18 Downloads (Pure)

The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation

Barker, G., Parnell, E., Van Basten, B., Buist, H., Adams, D. R. & Yarwood, S. J., 5 Dec 2017, In : Journal of Cardiovascular Disease and Development. 4, 4, p. 22-37 16 p.

Research output: Contribution to journalLiterature review

Open Access
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31 Downloads (Pure)
2016

Pro-survival Compounds

Mountford, J., Milligan, G. & Adams, D. R., 16 Jun 2016, IPC No. A61K31/4184, C07D233/54, C07D233/66, Patent No. WO2016092327A1, Priority date 11 Dec 2014

Research output: Patent

File
20 Downloads (Pure)

RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells

Kiely, M., Adams, D. R., Hayes, S. L., O'Connor, R., Baillie, G. S. & Kiely, P. A., 4 Sep 2016, In : Cellular Signalling.

Research output: Contribution to journalArticle

Open Access

Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances

Pyne, S., Adams, D. R. & Pyne, N. J., Apr 2016, In : Progress in Lipid Research. 62, p. 93-106 14 p.

Research output: Contribution to journalArticle

Open Access
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72 Downloads (Pure)

Sphingosine Kinases: Emerging Structure-Function Insights

Adams, D. R., Pyne, S. & Pyne, N. J., May 2016, In : Trends in Biochemical Sciences. 41, 5, p. 395-409 15 p.

Research output: Contribution to journalArticle

2015

Characterisation of SC332 a novel, non-ROCK inhibitory, stem cell survival agent suitable for large scale culture

Cowan, S., Adams, D., Milligan, G. & Mountford, J., Jun 2015, In : Cytotherapy. 17, 6, p. S70-S71 2 p.

Research output: Contribution to journalMeeting abstract

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

Bolger, G. B., Dunlop, A. J., Meng, D., Day, J. P., Klussmann, E., Baillie, G. S., Adams, D. R. & Houslay, M. D., Apr 2015, In : Cellular Signalling. 27, 4, p. 756-769 14 p.

Research output: Contribution to journalArticle

Open Access
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56 Downloads (Pure)
2013

Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)

Cameron, R. T., Coleman, R. G., Day, J. P., Yalla, K. C., Houslay, M. D., Adams, D. R., Shoichet, B. K. & Baillie, G. S., 1 May 2013, In : Biochemical Pharmacology. 85, 9, p. 1297-1305 9 p.

Research output: Contribution to journalArticle

Design, synthesis, and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones

Ochiai, K., Takita, S., Kojima, A., Eiraku, T., Ando, N., Iwase, K., Adams, D. R. & Kohno, Y., 10 Apr 2013, In : Abstracts of Papers: American Chemical Society Meetings. 1 p.

Research output: Contribution to journalMeeting abstract

Phosphodiesterase inhibitors. Part 5: Hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration

Ochiai, K., Takita, S., Kojima, A., Eiraku, T., Iwase, K., Kishi, T., Ohinata, A., Yageta, Y., Yasue, T., Adams, D. R. & Kohno, Y., 1 Jan 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 375-381 7 p.

Research output: Contribution to journalArticle

1 Downloads (Pure)

RACK(1) to the future – a historical perspective

Ron, D., Adams, D., Baillie, G. S., Long, A., O'Connor, R. & Kiely, P. A., 1 Aug 2013, In : Cell Communication and Signaling. 11, 4 p., 53.

Research output: Contribution to journalComment/debate

Open Access
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87 Downloads (Pure)
2012

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

Hudson, B. D., Christiansen, E., Tikhonova, I. G., Grundmann, M., Kostenis, E., Adams, D. R., Ulven, T. & Milligan, G., 13 Aug 2012, In : The FASEB Journal. 26, 12, p. 4951-65 15 p.

Research output: Contribution to journalArticle

Open Access
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168 Downloads (Pure)

Direct interaction between scaffolding proteins RACK1 and 14-3-3 zeta regulates brain-derived Neurotrophic Factor ( BDNF) Transcription

Neasta, J., Kiely, P. A., He, D-Y., Adams, D. R., O'Connor, R. & Ron, D., 2 Jan 2012, In : Journal of Biological Chemistry. 287, 1, p. 322-336 15 p.

Research output: Contribution to journalArticle

Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity

Ochiai, K., Takita, S., Eiraku, T., Kojima, A., Iwase, K., Kishi, T., Fukuchi, K., Yasue, T., Adams, D. R., Allcock, R. W., Jiang, Z. & Kohno, Y., 2012, In : Bioorganic and Medicinal Chemistry. 20, 5, p. 1644-58 15 p.

Research output: Contribution to journalArticle

Phosphodiesterase inhibitors. Part 4: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones

Ochiai, K., Takita, S., Kojima, A., Eiraku, T., Ando, N., Iwase, K., Kishi, T., Ohinata, A., Yageta, Y., Yasue, T., Adams, D. R. & Kohno, Y., 15 Sep 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 18, p. 5833-5838 6 p.

Research output: Contribution to journalArticle

Serine Phosphorylation of the Insulin-like Growth Factor I (IGF-1) Receptor C-terminal Tail Restrains Kinase Activity and Cell Growth

Kelly, G. M., Buckley, D. A., Kiely, P. A., Adams, D. R. & O'Connor, R., 10 Aug 2012, In : Journal of Biological Chemistry. 287, 33, p. 28180-28194 15 p.

Research output: Contribution to journalArticle

2011

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

Sin, Y. Y., Edwards, H. V., Li, X., Day, J. P., Christian, F., Dunlop, A. J., Adams, D., Zaccolo, M., Houslay, M. D. & Baillie, G. S., May 2011, In : Journal of Molecular and Cellular Cardiology. 50, 5, p. 872-883 12 p.

Research output: Contribution to journalArticle

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4)

Day, J. P., Lindsay, B., Riddell, T., Jiang, Z., Allcock, R. W., Abraham, A., Sookup, S., Christian, F., Bogum, J., Martin, E. K., Rae, R. L., Anthony, D., Rosair, G. M., Houslay, D. M., Huston, E., Baillie, G. S., Klussmann, E., Houslay, M. D. & Adams, D. R., 12 May 2011, In : Journal of Medicinal Chemistry. 54, 9, p. 3331-3347 17 p.

Research output: Contribution to journalArticle

Extracellular Loop 2 of the Free Fatty Acid Receptor 2 Mediates Allosterism of a Phenylacetamide Ago-Allosteric Modulator

Smith, N. J., Ward, R. J., Stoddart, L. A., Hudson, B. D., Kostenis, E., Ulven, T., Morris, J. C., Traenkle, C., Tikhonova, I. G., Adams, D. R. & Milligan, G., Jul 2011, In : Molecular Pharmacology. 80, 1, p. 163-173 11 p.

Research output: Contribution to journalArticle

Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast

Allcock, R. W., Blakli, H., Jiang, Z., Johnston, K. A., Morgan, K. M., Rosair, G. M., Iwase, K., Kohno, Y. & Adams, D. R., 1 Jun 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 11, p. 3307-3312 6 p.

Research output: Contribution to journalArticle

Phosphodiesterase inhibitors. Part 2: Design, synthesis, and structure-activity relationships of dual PDE3/4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory and bronchodilatory activity

Ochiai, K., Ando, N., Iwase, K., Kishi, T., Fukuchi, K., Ohinata, A., Zushi, H., Yasue, T., Adams, D. R. & Kohno, Y., 15 Sep 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 18, p. 5451-5456 6 p.

Research output: Contribution to journalArticle

RACK1, A multifaceted scaffolding protein: Structure and function

Adams, D. R., Ron, D. & Kiely, P. A., 6 Oct 2011, In : Cell Communication and Signaling. 9, 24 p., 22.

Research output: Contribution to journalLiterature review

Stem cell culture methods

Adams, D., Burton, P., Houslay, M. D., Milligan, G. & Mountford, J. C., 30 Nov 2011, IPC No. C12N5/0735, Patent No. EP2389436 A2

Research output: Patent

2010

Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells

Burton, P., Adams, D. R., Abraham, A., Allcock, R. W., Jiang, Z., McCahill, A., Gilmour, J., McAbney, J., Kaupisch, A., Kane, N. M., Baillie, G. S., Baker, A. H., Milligan, G., Houslay, M. D. & Mountford, J. C., 15 Dec 2010, In : Biochemical Journal. 432, 3, p. 575-584 10 p.

Research output: Contribution to journalArticle

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

Andrews, P. D., Becroft, M., Aspegren, A., Gilmour, J., James, M. J., McRae, S., Kime, R., Allcock, R. W., Abraham, A., Jiang, Z., Strehl, R., Mountford, J. C., Milligan, G., Houslay, M. D., Adams, D. R. & Frearson, J. A., 2010, In : Biochemical Journal. 432, 1, p. 21-33 13 p.

Research output: Contribution to journalArticle

Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells

Burton, P., Adams, D. R., Abraham, A., Allcock, R. W., Jiang, Z., McCahill, A., Gilmour, J., McAbney, J., Kane, N. M., Baillie, G. S., McKenzie, F. R., Baker, A. H., Houslay, M. D., Mountford, J. C. & Milligan, G., Aug 2010, In : Biochemical Society Transactions. 38, 4, p. 1058-1061 4 p.

Research output: Contribution to journalArticle

Novel anti-infective compounds from marine bacteria

Rahman, H., Austin, B., Mitchell, W. J., Morris, P. C., Jamieson, D. J., Adams, D. R., Spragg, A. M. & Schweizer, M., Mar 2010, In : Marine Drugs. 8, 3, p. 498-518 21 p.

Research output: Contribution to journalLiterature review

P62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways

Christian, F., Anthony, D. F., Vadrevu, S., Riddell, T., Day, J. P., McLeod, R., Adams, D. R., Baillie, G. S. & Houslay, M. D., Oct 2010, In : Cellular Signalling. 22, 10, p. 1576-1596 21 p.

Research output: Contribution to journalArticle

Putting the lid on phosphodiesterase 4

Houslay, M. D. & Adams, D. R., Jan 2010, In : Nature Biotechnology. 28, 1, p. 38-40 3 p.

Research output: Contribution to journalArticle

Pyrazolopyridine-4-Yl Pyridazinone Derivatives and Addition Salts Thereof, and PDE Inhibitors Comprising the Same Derivatives or Salts as Active Ingredient

Kohno, Y., Adams, D. & Ando, N., 27 Jul 2010, IPC No. A61K31/501; A61P11/06; A61P25/24; A61P29/00; A61P33/08; C07D401/14; C07D403/14, Patent No. US7763617(B2)

Research output: Patent

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK

Li, X., Vadrevu, S., Dunlop, A., Day, J., Advant, N., Troeger, J., Klussmann, E., Jaffrey, E., Hay, R. T., Adams, D. R., Houslay, M. D. & Baillie, G. S., 15 May 2010, In : Biochemical Journal. 428, 1, p. 55-65 11 p.

Research output: Contribution to journalArticle

Stem cell culture methods

Adams, D., Burton, P., Houslay, M. D., Milligan, G. & Mountford, J. C., 16 Sep 2010, IPC No. C12N5/0735, Patent No. WO2010084300(A3)

Research output: Patent

Stem cell culture methods

Adams, D., Burton, P., Houslay, M. D., Milligan, G. & Mountford, J. C., 29 Jul 2010, IPC No. C12N5/0735, Patent No. WO2010084300 A2

Research output: Patent

2009

A scanning peptide array approach uncovers association sites within the JNK/βarrestin signalling complex

Li, X., MacLeod, R., Dunlop, A. J., Edwards, H. V., Advant, N., Gibson, L. C. D., Devine, N. M., Brown, K. M., Adams, D. R., Houslay, M. D. & Baillie, G. S., 20 Oct 2009, In : FEBS Letters. 583, 20, p. 3310-3316 7 p.

Research output: Contribution to journalArticle

MEK1 binds directly to βarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization

Meng, D., Lynch, M. J., Huston, E., Beyermann, M., Eichhorst, J., Adams, D. R., Klusmann, E., Houslay, M. D. & Baillie, G. S., 24 Apr 2009, In : Journal of Biological Chemistry. 284, 17, p. 11425-11435 11 p.

Research output: Contribution to journalArticle

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase

Kiely, P. A., Baillie, G. S., Barrett, R., Buckley, D. A., Adams, D. R., Houslay, M. D. & O'Connor, R., 24 Jul 2009, In : Journal of Biological Chemistry. 284, 30, p. 20263-20274 12 p.

Research output: Contribution to journalArticle

2008

2-SUBSTITUTED-6-(PYRAZOLOPYRIDIN-3-YL)PYRIDAZINONE DERIVATIVE, ADDUCT SALT OF THE SAME AND PDE INHIBITOR BY USING THEM AS ACTIVE INGREDIENT

Translated title of the contribution: 2-SUBSTITUTED-6-(PYRAZOLOPYRIDIN-3-YL)PYRIDAZINONE DERIVATIVE, ADDUCT SALT OF THE SAME AND PDE INHIBITOR BY USING THEM AS ACTIVE INGREDIENT Kono, Y. & Adams, D., 9 Oct 2008, IPC No. A61K31/501; A61P1/04; A61P11/06; A61P15/10; A61P17/00; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P29/00; A61P37/08; A61P43/00; A61P9/04; A61P9/10; A61P9/12; C07D471/04, Patent No. JP2008239558(A)

Research output: Patent

Concise routes to pyrazolo[1,5-a]pyridin-3-yl pyridazin-3-ones

Johnston, K. A., Allcock, R. W., Jiang, Z., Collier, I. D., Blakli, H., Rosair, G. M., Bailey, P. D., Morgan, K. M., Kohno, Y. & Adams, D. R., 2008, In : Organic and Biomolecular Chemistry. 6, 1, p. 175-186 12 p.

Research output: Contribution to journalArticle

Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β2-adrenoceptor and the ERK1/2 MAPKs: Implications for β2-adrenoceptor signalling via the ERK1/2 MAPKs

Xu, T. R., Baillie, G. S., Bhari, N., Houslay, T. M., Pitt, A. M., Adams, D. R., Kolch, W., Houslay, M. D. & Milligan, G., 1 Jul 2008, In : Biochemical Journal. 413, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

Pyrazolopyridine-4-Yl Pyridazinone Derivatives and Addition Salts Thereof, and Pde Inhibitors Comprising the Same Derivatives or Salts as Active Ingredient

Kohno, Y., Adams, D. & Ando, N., 28 Aug 2008, IPC No. A61P11/06; A61P15/00; A61P25/00; A61P29/00; A61P37/08; A61P43/00; A61P7/02; A61P9/00; C07D401/14, Patent No. US2008207902(A1)

Research output: Patent