If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Research Expertise:  Very wide experience of synthetic organic, biological and medicinal chemistry, much of it focused in collaborations with academic life science groups and pharmaceutical industry to unravel aspects of key cellular signalling pathways and develop compounds to modulate these with a therapeutic outcome. Major projects since 2000 have included: design and synthesis of phosphodiesterase type 4 (PDE4) inhibitors, protein tyrosine phosphatase 1B (PTP1B) inhibitors and chemokine receptor (CXCR2) antagonists for treatment of asthma, diabetes and chronic obstructive pulmonary disease respectively (UK£2m industrial funding, as part of programmes of total value >UK£15m); design and synthesis of compounds to modulate stem cell development (£1m from ITI Life Sciences as part of programme of total value UK£9.5m). co-I on recently commenced multicentre programme funded by the Scottish Funding Council (2011, UK£2.5m) to develop protocols for red blood cell production from pluripotent stem cells. co-I on additional awards from UK Research Councils and NHS totaling UK£0.94m since 2000 for research on nitric oxide synthase and on programmes directed towards the discovery of natural products with antimicrobial activity against organisms responsible for nosocomial infections. Additional interests in the function of RACK1 as a scaffolding protein, GPCR signalling (free fatty acid receptor 2), RTK signalling (IGF1R), the design and synthesis of functional nitric oxide synthase mimetics and in antiviral medicinal chemistry. Experienced collaborator with academic life science groups working on cellular signalling pathways [Houslay group, Glasgow Univ, exploration of PDE4 structure and function; contributing to MRC/G0400053 (1/10/2006, 48 months, UK£1.9m) & EU FP6/037189 (1/10/2006, 36 months, €3m)] [Milligan group, Glasgow Univ, ligands for FFA2; contributing to Wellcome Trust 089600/Z/09/Z (2010, 36 months, UK£231k)]. A major current focus is on the role of RACK1 in IGF-I/adhesion-mediated signalling relevant to regulation of cytoskeleton and cell motility (analysis of interactions with partner proteins – actin, myosin, PKC, FAK etc) collaborations with (O’Connor gp, Cork;  Kiely group, Limerick;  Long gp, Trinity College Dublin;  Ron gp, UCSF).

Research interests

biological chemistry

medicinal chemistry

GPCR signalling

RTK signalling

cyclic nucleotide signalling

phosphodiesterases

RACK1 scaffolding protein

kinases

phosphatases

nitric oxide synthase

antiviral medicinal chemistry

antibiotics

natural products

Keywords

  • QD Chemistry

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 1 Similar Profiles
Phosphoric Diester Hydrolases Medicine & Life Sciences
Type 4 Cyclic Nucleotide Phosphodiesterase Medicine & Life Sciences
Protein Isoforms Medicine & Life Sciences
Cyclic AMP Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Phosphodiesterase Inhibitors Chemical Compounds
Cycloaddition Chemical Compounds
Peptides Medicine & Life Sciences

Co Author Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1989 2018

Compounds and their use as PDE4 activators

Adam, J. M. & Adams, D. R., 5 Apr 2018, IPC No. A61K31/4196A61P1/00A61P11/00A61P13/00A61P35/00A61P5/00A61P9/00C07D249/08C07D403/12, World Intellectual Property Organization (WIPO), Patent No. WO2018060704(A1), Priority date 28 Sep 2016, Priority No. GB20160016439 20160928

Research output: Patent

Open Access
File
Type 4 Cyclic Nucleotide Phosphodiesterase
Cyclic Nucleotides
Second Messenger Systems
Cyclic AMP
Protein Isoforms

Sphingosine 1-phosphate and cancer

Pyne, N. J., El Buri, A., Adams, D. R. & Pyne, S., May 2018, In : Advances in Biological Regulation. 68, p. 97-106 10 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Neoplasms
Fibroblasts
TNF Receptor-Associated Factor 2
Phosphorylation

Sphingosine Kinases as Druggable Targets

Pyne, S., Adams, D. R. & Pyne, N. J., 20 Feb 2018, Handbook of Experimental Pharmacology. Berlin: Springer, 28 p. (Handbook of Experimental Pharmacology)

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Sphingosine
Enzymes
Pulmonary Hypertension
Protein Isoforms
Binding Sites
Open Access
File
Lysosphingolipid Receptors
Exosomes
Extracellular Signal-Regulated MAP Kinases
Fibroblasts
Breast Neoplasms

FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system

Yalla, K. C., Elliott, C., Day, J. P., Findlay, J., Barratt, S., Hughes, Z. A., Wilson, L., Whiteley, E., Popiolek, M., Li, Y., Dunlop, J., Killick, R., Adams, D. R., Brandon, N. J., Houslay, M. D., Hao, B. & Baillie, G. S., 20 Jul 2017, In : Molecular Psychiatry. 23, 5, p. 1278–1286 9 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin
Schizophrenia
Proteasome Endopeptidase Complex
Induced Pluripotent Stem Cells
Frameshift Mutation