Research Output per year
Personal profile
Research interests
Research Expertise: Very wide experience of synthetic organic, biological and medicinal chemistry, much of it focused in collaborations with academic life science groups and pharmaceutical industry to unravel aspects of key cellular signalling pathways and develop compounds to modulate these with a therapeutic outcome. Major projects since 2000 have included: design and synthesis of phosphodiesterase type 4 (PDE4) inhibitors, protein tyrosine phosphatase 1B (PTP1B) inhibitors and chemokine receptor (CXCR2) antagonists for treatment of asthma, diabetes and chronic obstructive pulmonary disease respectively (UK£2m industrial funding, as part of programmes of total value >UK£15m); design and synthesis of compounds to modulate stem cell development (£1m from ITI Life Sciences as part of programme of total value UK£9.5m). co-I on recently commenced multicentre programme funded by the Scottish Funding Council (2011, UK£2.5m) to develop protocols for red blood cell production from pluripotent stem cells. co-I on additional awards from UK Research Councils and NHS totaling UK£0.94m since 2000 for research on nitric oxide synthase and on programmes directed towards the discovery of natural products with antimicrobial activity against organisms responsible for nosocomial infections. Additional interests in the function of RACK1 as a scaffolding protein, GPCR signalling (free fatty acid receptor 2), RTK signalling (IGF1R), the design and synthesis of functional nitric oxide synthase mimetics and in antiviral medicinal chemistry. Experienced collaborator with academic life science groups working on cellular signalling pathways [Houslay group, Glasgow Univ, exploration of PDE4 structure and function; contributing to MRC/G0400053 (1/10/2006, 48 months, UK£1.9m) & EU FP6/037189 (1/10/2006, 36 months, €3m)] [Milligan group, Glasgow Univ, ligands for FFA2; contributing to Wellcome Trust 089600/Z/09/Z (2010, 36 months, UK£231k)]. A major current focus is on the role of RACK1 in IGF-I/adhesion-mediated signalling relevant to regulation of cytoskeleton and cell motility (analysis of interactions with partner proteins – actin, myosin, PKC, FAK etc) collaborations with (O’Connor gp, Cork; Kiely group, Limerick; Long gp, Trinity College Dublin; Ron gp, UCSF).
Research interests
biological chemistry
medicinal chemistry
GPCR signalling
RTK signalling
cyclic nucleotide signalling
phosphodiesterases
RACK1 scaffolding protein
kinases
phosphatases
nitric oxide synthase
antiviral medicinal chemistry
antibiotics
natural products
Keywords
- QD Chemistry
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Research Output
Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases
Omar, F., Findlay, J. E., Carfray, G., Allcock, R. W., Jiang, Z., Moore, C., Muir, A. L., Lannoy, M., Fertig, B. A., Mai, D., Day, J. P., Bolger, G., Baillie, G. S., Schwiebert, E., Klussmann, E., Pyne, N. J., Ong, A. C. M., Bowers, K., Adam, J. M., Adams, D. R. & 2 others, , 2 Jul 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13320-13329 10 p.Research output: Contribution to journal › Article
Open Access
File
Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2
Adams, D. R., Tawati, S., Berretta, G., Lopez Rivas, P., Baiget, J., Jiang, Z., Alsfouk, A., Mackay, S. P., Pyne, N. & Pyne, S., 11 Apr 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3658-3676 19 p.Research output: Contribution to journal › Article
Open Access
File
Compounds and their use as PDE4 activators
Adam, J. M. & Adams, D. R., 5 Apr 2018, IPC No. A61K31/4196, A61P1/00, A61P11/00, A61P13/00, A61P35/00, A61P5/00, A61P9/00, C07D249/08, C07D403/12, World Intellectual Property Organization (WIPO), Patent No. WO2018060704(A1), Priority date 28 Sep 2016, Priority No. GB20160016439 20160928Research output: Patent
Open Access
File
17
Downloads
(Pure)
Sphingosine 1-phosphate and cancer
Pyne, N. J., El Buri, A., Adams, D. R. & Pyne, S., May 2018, In : Advances in Biological Regulation. 68, p. 97-106 10 p.Research output: Contribution to journal › Article
Sphingosine Kinases as Druggable Targets
Pyne, S., Adams, D. R. & Pyne, N. J., 2018, Lipid Signaling in Human Diseases. Springer, p. 49-76 28 p. (Handbook of Experimental Pharmacology; vol. 259).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)
Activities
- 2 Other
Mironid Limited: Head of Research Chemistry
David Roger Adams (Recipient)29 Apr 2014 → …
Activity: Other