Research Output per year
Personal profile
Research interests
Research Expertise: Very wide experience of synthetic organic, biological and medicinal chemistry, much of it focused in collaborations with academic life science groups and pharmaceutical industry to unravel aspects of key cellular signalling pathways and develop compounds to modulate these with a therapeutic outcome. Major projects since 2000 have included: design and synthesis of phosphodiesterase type 4 (PDE4) inhibitors, protein tyrosine phosphatase 1B (PTP1B) inhibitors and chemokine receptor (CXCR2) antagonists for treatment of asthma, diabetes and chronic obstructive pulmonary disease respectively (UK£2m industrial funding, as part of programmes of total value >UK£15m); design and synthesis of compounds to modulate stem cell development (£1m from ITI Life Sciences as part of programme of total value UK£9.5m). co-I on recently commenced multicentre programme funded by the Scottish Funding Council (2011, UK£2.5m) to develop protocols for red blood cell production from pluripotent stem cells. co-I on additional awards from UK Research Councils and NHS totaling UK£0.94m since 2000 for research on nitric oxide synthase and on programmes directed towards the discovery of natural products with antimicrobial activity against organisms responsible for nosocomial infections. Additional interests in the function of RACK1 as a scaffolding protein, GPCR signalling (free fatty acid receptor 2), RTK signalling (IGF1R), the design and synthesis of functional nitric oxide synthase mimetics and in antiviral medicinal chemistry. Experienced collaborator with academic life science groups working on cellular signalling pathways [Houslay group, Glasgow Univ, exploration of PDE4 structure and function; contributing to MRC/G0400053 (1/10/2006, 48 months, UK£1.9m) & EU FP6/037189 (1/10/2006, 36 months, €3m)] [Milligan group, Glasgow Univ, ligands for FFA2; contributing to Wellcome Trust 089600/Z/09/Z (2010, 36 months, UK£231k)]. A major current focus is on the role of RACK1 in IGF-I/adhesion-mediated signalling relevant to regulation of cytoskeleton and cell motility (analysis of interactions with partner proteins – actin, myosin, PKC, FAK etc) collaborations with (O’Connor gp, Cork; Kiely group, Limerick; Long gp, Trinity College Dublin; Ron gp, UCSF).
Research interests
biological chemistry
medicinal chemistry
GPCR signalling
RTK signalling
cyclic nucleotide signalling
phosphodiesterases
RACK1 scaffolding protein
kinases
phosphatases
nitric oxide synthase
antiviral medicinal chemistry
antibiotics
natural products
Keywords
- QD Chemistry
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Research Output 1989 2017
FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system
Yalla, K. C., Elliott, C., Day, J. P., Findlay, J., Barratt, S., Hughes, Z. A., Wilson, L., Whiteley, E., Popiolek, M., Li, Y., Dunlop, J., Killick, R., Adams, D. R., Brandon, N. J., Houslay, M. D., Hao, B. & Baillie, G. S. 20 Jul 2017 In : Molecular Psychiatry. p. 1-9 9 p.Research output: Contribution to journal › Article
Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners
Houslay, K. F., Christian, F., MacLeod, R., Adams, D. R., Houslay, M. D. & Baillie, G. S. 3 Feb 2017 In : Biochemical Journal. 474, 4, p. 597-609 13 p.Research output: Contribution to journal › Article
Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1
Parnell, E., McElroy, S. P., Wiejak, J., Baillie, G. L., Porter, A., Adams, D. R., Rehmann, H., Smith, B. O. & Yarwood, S. J. 22 Mar 2017 In : Scientific Reports. 7, 294Research output: Contribution to journal › Article
Sphingosine 1-phosphate and cancer
Pyne, N. J., El Buri, A., Adams, D. R. & Pyne, S. 15 Sep 2017 In : Advances in Biological Regulation.Research output: Contribution to journal › Article
Sphingosine Kinase 2 in Autoimmune/Inflammatory Disease and the Development of Sphingosine Kinase 2 Inhibitors
Pyne, N. J., Adams, D. R. & Pyne, S. Jul 2017 In : Trends in Pharmacological Sciences. 38, 7, p. 581-591Research output: Contribution to journal › Article