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Research Output 2000 2019

  • 44 Article
  • 1 Chapter (peer-reviewed)
Cosmetics
packaging
toxicity
clays
Toxicity
Open Access
File
toxicity
toxicology
monoculture
translocation
trend
nanocomposites
Nanocomposites
Macrophages
keratinocytes
Product Packaging

The mechanism-based toxicity screening of particles with use in the food and nutrition sector via the ToxTracker reporter system

Brown, D. M., Danielsen, P. H., Derr, R., Moelijker, N., Fowler, P., Stone, V., Hendriks, G., Møller, P. & Kermanizadeh, A., 4 Jul 2019, In : Toxicology in Vitro. 61, 104594.

Research output: Contribution to journalArticle

Nutrition
Toxicity
Assays
Screening
Food
Open Access
File
Kupffer cells
nanomaterials
Kupffer Cells
Nanostructures
Macrophages
2018

A cross-species and model comparison of the acute toxicity of nanoparticles used in the pigment and ink industries

Brown, D. M., Johnston, H. J., Gaiser, B. K., Pinna, N., Caputo, G., Culha, M., Kelestemur, S., Altunbek, M., Stone, V., Roy, J. C., Kinross, J. H. & Fernandes, T. F., Jul 2018, In : NanoImpact. 11, p. 20–32 13 p.

Research output: Contribution to journalArticle

Open Access
File
Ink
Nanoparticles
Industry
Zinc Oxide
Daphnia
Open Access
File
Nanostructures
Zebrafish
Rodentia
Oxidative Stress
Embryonic Structures
Open Access
Oxidative stress
Flow cytometry
Nanostructures
Nanostructured materials
Reactive Oxygen Species

Assessing the bioactivity of crystalline silica in heated high-temperature insulation wools

Boyles, M., Brown, D. M., Knox, J., Horobin, M., Miller, M. R., Johnston, H. J. & Stone, V., 17 Oct 2018, In : Inhalation Toxicology.

Research output: Contribution to journalArticle

Open Access
File

Corrigendum to "the role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review"

Kermanizadeh, A., Chauché, C., Brown, D. M., Loft, S. & Møller, P., Apr 2018, In : Environmental and Molecular Mutagenesis. 59, 3, p. 263-263 1 p.

Research output: Contribution to journalArticle

Toxicological hazard analysis of nanomaterials with potential for utilization in consumer goods

Kermanizadeh, A., Brown, D. M. & Møller, P., 2018, Nanomaterials for food applications . Elsevier, p. 355-380 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Transcriptional profiling reveals gene expression changes associated with inflammation and cell proliferation following short-term inhalation exposure to copper oxide nanoparticles

Costa, P. M., Gosens, I., Williams, A., Farcal, L., Pantano, D., Brown, D. M., Stone, V., Cassee, F. R., Halappanavar, S. & Fadeel, B., Mar 2018, In : Journal of Applied Toxicology. 38, 3, p. 385-397 13 p.

Research output: Contribution to journalArticle

Open Access
File
Inhalation Exposure
Copper oxides
Cell proliferation
Gene Expression Profiling
Gene expression
2017
Open Access
File
Caco-2 Cells
Nanostructures
Oxides
Copper
Epithelial Cells

Releases from transparent blue automobile coatings containing nanoscale copper phthalocyanine and their effects on J774 A1 macrophages

Pang, C., Neubauer, N., Boyles, M., Brown, D. M., Kanase, N., Hristozov, D., Fernandes, T., Stone, V., Wohlleben, W. & Marcomini, A., Jul 2017, In : NanoImpact. 7, p. 75-83 9 p.

Research output: Contribution to journalArticle

Open Access
File
automobiles
coatings
macrophages
copper
toxicity

Surfactants from Itaconic Acid: Toxicity to HaCaT keratinocytes in vitro, Micellar Solubilization, and Skin Permeation Enhancement of Hydrocortisone

Abruzzo, A., Armenise, N., Bigucci, F., Cerchiara, T., Gösser, M. B., Samori, C., Galletti, P., Tagliavini, E., Brown, D. M., Johnston, H. J., Fernandes, T. F. & Luppi, B., 30 May 2017, In : International Journal of Pharmaceutics. 524, 1-2, p. 9–15 7 p.

Research output: Contribution to journalArticle

Open Access
File
Surface-Active Agents
Permeation
Toxicity
Hydrocortisone
Skin

The effect of aluminium and sodium impurities on the in vitro toxicity and pro-inflammatory potential of cristobalite

Nattrass, C., Horwell, C. J., Damby, D. E., Brown, D. M. & Stone, V., Nov 2017, In : Environmental Research. 159, p. 164-175 12 p.

Research output: Contribution to journalArticle

Open Access
File
Aluminum
Silicon Dioxide
Sodium
In Vitro Techniques
Macrophages
2016

Inflammatory responses of a human keratinocyte cell line to 10 nm citrate- and PEG-coated silver nanoparticles

Bastos, V., Brown, D. M., Johnston, H. J., Daniel-da-Silva, A. L., Duarte, I. F., Santos, C. & Oliveira, H., 20 Jul 2016, In : Journal of Nanoparticle Research. 18, 205.

Research output: Contribution to journalArticle

Open Access
File
Keratinocytes
Silver
Citric Acid
Nanoparticles
Cytokines

Organ burden and pulmonary toxicity of nano-sized copper (II) oxide particles after short-term inhalation exposure

Gosens, I., Cassee, F. R., Zanella, M., Manodori, L., Brunelli, A., Costa, A. L., Bokkers, B. G. H., De Jong, W. H., Brown, D. M., Hristozov, D. & Stone, V., 2016, In : Nanotoxicology. 10, 8, p. 1084-1095 12 p.

Research output: Contribution to journalArticle

Inhalation Exposure
Copper oxides
Nose
Oxides
Inhalation

The influence of Citrate or PEG coating on silver nanoparticle toxicity to a human keratinocyte cell line

Bastos, V., Ferreira de Oliveira, J. M. P., Brown, D. M., Johnston, H. J., Malheiro, E., Daniel-da-Silva, A. L., Duarte, I. F., Santos, C. & Oliveira, H., 13 May 2016, In : Toxicology Letters. 249, p. 29-41 13 p.

Research output: Contribution to journalArticle

Open Access
File
Keratinocytes
Silver
Citric Acid
Nanoparticles
Cell Cycle
2015
Nanostructured materials
Optical microscopy
Tissue
Imaging techniques
Microscopic examination

Mechanism of neutrophil activation and toxicity elicited by engineered nanomaterials

Johnston, H. J., Brown, D. M., Kanase, N., Euston, M., Gaiser, B. K., Robb, C. T., Dyrynda, E., Rossi, A. G., Brown, E. R. & Stone, V., Aug 2015, In : Toxicology in Vitro. 29, 5, p. 1172-1184 13 p.

Research output: Contribution to journalArticle

nanomaterials
Neutrophil Activation
Nanostructures
Nanostructured materials
Toxicity

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos

Boyles, M. S. P., Young, L., Brown, D. M., MacCalman, L., Cowie, H., Moisala, A., Smail, F., Smith, P. J. W., Proudfoot, L., Windle, A. H. & Stone, V., Oct 2015, In : Toxicology in Vitro. 29, 7, p. 1513-1528 16 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Macrophages
Asbestos
Cytotoxicity
Phagocytosis

Silica nanoparticles and biological dispersants: genotoxic effects on A549 lung epithelial cells

Brown, D. M., Varet, J., Johnston, H., Chrystie, A. & Stone, V., Oct 2015, In : Journal of Nanoparticle Research. 17, 10, 16 p., 410.

Research output: Contribution to journalArticle

Lung
Silica
Silicon Dioxide
lungs
Nanoparticles

The global variability of diatomaceous earth toxicity: A physicochemical and in vitro investigation

Nattrass, C., Horwell, C. J., Damby, D. E., Kermanizadeh, A., Brown, D. M. & Stone, V., 10 Jul 2015, In : Journal of Occupational Medicine and Toxicology. 10, 23.

Research output: Contribution to journalArticle

Open Access
File
Diatomaceous Earth
Toxicity
Silicon Dioxide
Earth (planet)
Crystalline materials

The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: a review

Kermanizadeh, A., Chauché, C., Brown, D. M., Loft, S. & Møller, P., Mar 2015, In : Environmental and Molecular Mutagenesis. 56, 2, p. 111-124 14 p.

Research output: Contribution to journalArticle

Nanostructures
Oxidation-Reduction
Reactive Oxygen Species
Oxidative Stress
DNA Damage
Macrophages
Cytotoxicity
Gold
Nanoparticles
Rats
Nanostructures
Silicon Dioxide
Albumins
Macrophages
Cytokines

The role of Kupffer cells in the hepatic response to silver nanoparticles

Kermanizadeh, A., Chauché, C., Balharry, D., Brown, D. M., Kanase, N., Boczkowski, J., Lanone, S. & Stone, V., 1 Jan 2014, In : Nanotoxicology. 8, SUPPL. 1, p. 149-154 6 p.

Research output: Contribution to journalArticle

Kupffer Cells
Silver
Liver
Nanoparticles
Interleukin-10
Nanostructures
Toxicology
Liver
Waste Products
Carbohydrate Metabolism
2013

Effects of alpha-lipoic acid on mtDNA damage after isolated muscle contractions

Fogarty, M. C., Devito, G., Hughes, C. M., Burke, G., Brown, J. C., Mceneny, J., Brown, D. M., McClean, C. & Davison, G. W., Aug 2013, In : Medicine and Science in Sports and Exercise. 45, 8, p. 1469-1477 9 p.

Research output: Contribution to journalArticle

Nanostructures
Nanostructured materials
Gene expression
Liver
Neutrophils
2011

Quantum dot cytotoxicity in vitro: an investigation into the cytotoxic effects of a series of different surface chemistries and their core/shell materials

Clift, M. J. D., Varet, J., Hankin, S. M., Brownlee, B., Davidson, A. M., Brandenberger, C., Rothen-Rutishauser, B., Brown, D. M. & Stone, V., Dec 2011, In : Nanotoxicology. 5, 4, p. 664-674 11 p.

Research output: Contribution to journalArticle

The uptake and intracellular fate of a series of different surface coated quantum dots in vitro

Clift, M. J. D., Brandenberger, C., Rothen-Rutishauser, B., Brown, D. M. & Stone, V., 8 Jun 2011, In : Toxicology. 286, 1-3, p. 58-68

Research output: Contribution to journalArticle

Quantum Dots
Polystyrenes
Macrophages
In Vitro Techniques
Lysosomes
2010

An investigation into the potential for different surface-coated quantum dots to cause oxidative stress and affect macrophage cell signalling in vitro

Clift, M. J. D., Boyles, M. S. P., Brown, D. M. & Stone, V., Jun 2010, In : Nanotoxicology. 4, 2, p. 139-149 11 p.

Research output: Contribution to journalArticle

Evaluating the uptake and intracellular fate of polystyrene nanoparticles by primary and hepatocyte cell lines in vitro

Johnston, H. J., Semmler-Behnke, M., Brown, D. M., Kreyling, W., Tran, L. & Stone, V., Jan 2010, In : Toxicology and Applied Pharmacology. 242, 1, p. 66-78 13 p.

Research output: Contribution to journalArticle

Polystyrenes
Nanoparticles
Hepatocytes
Cell Line
Bile

Interaction between nanoparticles and cytokine proteins: impact on protein and particle functionality

Brown, D. M., Dickson, C., Duncan, P., Al-Attili, F. & Stone, V., 28 May 2010, In : Nanotechnology. 21, 21, 9 p., 215104.

Research output: Contribution to journalArticle

Relating the physicochemical characteristics and dispersion of multiwalled carbon nanotubes in different suspension media to their oxidative reactivity in vitro and inflammation in vivo

Rothen-Rutishauser, B., Brown, D. M., Piallier-Boyles, M., Kinloch, I. A., Windle, A. H., Gehr, P. & Stone, V., 2010, In : Nanotoxicology. 4, 3, p. 331-42 12 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Reactive Oxygen Species
Suspensions
Inflammation
Cell-Free System

The effects of serum on the toxicity of manufactured nanoparticles

Clift, M. J. D., Bhattacharjee, S., Brown, D. M. & Stone, V., 20 Oct 2010, In : Toxicology Letters. 198, 3, p. 358-365 8 p.

Research output: Contribution to journalArticle

2008

The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line

Clift, M. J. D., Rothen-Rutishauser, B., Brown, D. M., Duffin, R., Donaldson, K., Proudfoot, L., Guy, K. & Stone, V., 1 Nov 2008, In : Toxicology and Applied Pharmacology. 232, 3, p. 418-427 10 p.

Research output: Contribution to journalArticle

2000

Toxic and inflammatory effects of filters frequently used for the collection of airborne particulate matter

Dick, C. A. J., Stone, V., Brown, D. M., Watt, M., Cherrie, J. W., Howarth, S., Seaton, A. & Donaldson, K., 2000, In : Atmospheric Environment. 34, 16, p. 2587-2592 6 p.

Research output: Contribution to journalArticle

Polycarbonates
particulate matter
filter
Rats
Toxic materials