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Personal profile

Research interests

David's research interests include: The role of oxidative stress in nanoparticle/cell interactions. The role of calcium as a signalling molecule. The effects of particulate air pollution in the lung.

Biography

David's career began in the early 1970s at the Institute of Occupational Medicine (IOM), at that time run by the National coal Board. The Institute conducted research into the health and diseases of miners exposed to coal dust during their working career. This research led to further studies involving workers exposed to asbestos fibres and into cell based studies where attempts were made to understand the effects of man-made mineral fibres in the lung. David moved to the IOM unit at the City Hospital where this work was continued until the mid 1990s.  He then moved to Napier University in 1995 to study the effects of various nanoparticles in the respiratory system under the directorship of Professor Ken Donaldson. During his time at Napier University, he developed various in vitro models to investigate the cellular effects of nanoparticles exposure in different organ systems in the body. David has recently relocated to Heriot-Watt University where this work is continuing.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Co Author Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2000 2018

A cross-species and model comparison of the acute toxicity of nanoparticles used in the pigment and ink industries

Brown, D. M., Johnston, H. J., Gaiser, B. K., Pinna, N., Caputo, G., Culha, M., Kelestemur, S., Altunbek, M., Stone, V., Roy, J. C., Kinross, J. H. & Fernandes, T. F., Jul 2018, In : NanoImpact. 11, p. 20–32 13 p.

Research output: Contribution to journalArticle

Ink
Nanoparticles
Industry
Zinc Oxide
Daphnia
Open Access
File
Nanostructures
Zebrafish
Rodentia
Oxidative Stress
Embryonic Structures
Open Access
Oxidative stress
Flow cytometry
Nanostructures
Nanostructured materials
Reactive Oxygen Species

Assessing the bioactivity of crystalline silica in heated high-temperature insulation wools

Boyles, M., Brown, D. M., Knox, J., Horobin, M., Miller, M. R., Johnston, H. J. & Stone, V., 17 Oct 2018, In : Inhalation Toxicology.

Research output: Contribution to journalArticle

Open Access
File

Transcriptional profiling reveals gene expression changes associated with inflammation and cell proliferation following short-term inhalation exposure to copper oxide nanoparticles

Costa, P. M., Gosens, I., Williams, A., Farcal, L., Pantano, D., Brown, D. M., Stone, V., Cassee, F. R., Halappanavar, S. & Fadeel, B., Mar 2018, In : Journal of Applied Toxicology. 38, 3, p. 385-397 13 p.

Research output: Contribution to journalArticle

Open Access
File
Inhalation Exposure
Copper oxides
Cell proliferation
Gene Expression Profiling
Gene expression