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Personal profile

Research interests

We are a catalysis and synthesis group with particular interest in the following areas:

1. Gold Catalysis
In the past decade, gold has emerged as a powerful catalyst for the electrophilic activation of carbon-carbon p bonds. Gold catalysis represents a new frontier in catalysis with scope for further discoveries and development, particularly in the field of asymmetric gold catalysis. We are interested in the development of novel gold catalysed reactions with the aim of expanding the current toolkit of synthetic techniques. Recent highlights from our group include developing novel gold-catalysed reactions with cyclopropenes and allenes.

For representative publications, see: Org. Lett., 2012, 14, 898. Abstract; Chem. Commun.,2011, 47, 1333 - 1335. Abstract; Org. Biomol. Chem., 2010, 8, 4090 - 4095. Abstract; Org. Lett.2010, 12, 484-487. Abstract; Chem. Commun., 2008, 6405-6407. Abstract

2. Palladium Catalysis
We have recently developed a mild and ligand free cationic Pd(II) system for conjugate additions to hindered ?-substituted cyclohexenones. Current work in the group centres around the development and futher applications of the cationic Pd(II) system.

For representative publications: Org. Lett., 2012, ASAP, DOI:10.1021/ol300794a. Abstract

3. N-Heterocyclic Carbene (NHC) - Type Ligands for Catalysis
The chemistry of N-heterocyclic carbenes (NHCs) and in particular their application as ligands, has developed rapidly since the synthesis of the first isolable species in 1991. NHC ligands are active in various transition metal catalysed reactions as well as in organocatalytic reactions. This area holds great promise in terms of the design of novel and modular ligands with different stereochemical topography.

For representative publication, see: Chem. Commun., 2011, 47, 328 - 330. Abstract and review: Aust. J. Chem. 2011, 64, 1118–1132. Abstract

4. Chiral rotaxanes
One of the most interesting and yet least exploited features of rotaxanes is chirality - a rotaxane consisting of an asymmetric rotor and asymmetric axis can have cyclochirality, even if both the rotor and axis are themselves achiral. To date, there are no efficient methods for the catalytic enantioselective synthesis of cyclochiral rotaxanes. We are interested in tackling this challenging problem using tools from the field of asymmetric catalysis.

Research Group Contact Details

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  • 5 Similar Profiles
Gold Chemical Compounds
Catalysis Chemical Compounds
Alkenes Chemical Compounds
Catalysts Chemical Compounds
Ethers Chemical Compounds

Research Output 2008 2018

Dual copper- and photoredox-catalysed reactions

McLean, E. B. & Lee, A-L., 20 Sep 2018, In : Tetrahedron. 74, 38, p. 4881-4902 22 p.

Research output: Contribution to journalReview article

Transition metals

Gold(I)-Catalysed Hydroarylation of 1,3-Disubstituted Allenes with Efficient Axial-to-Point Chirality Transfer

Sutherland, D. R., Kinsman, L., Angiolini, S. M., Rosair, G. M. & Lee, A-L., 11 May 2018, In : Chemistry - A European Journal. 24, 27, p. 7002-7009 8 p.

Research output: Contribution to journalArticle


Metal-, Photocatalyst-, and Light-Free, Late-Stage C–H Alkylation of Heteroarenes and 1,4-Quinones Using Carboxylic Acids

Sutherland, D. R., Veguillas, M., Oates, C. L. & Lee, A., 2 Nov 2018, In : Organic Letters. 20, 21, p. 6863-6867 5 p.

Research output: Contribution to journalArticle

Light Metals
Carboxylic Acids

Rapid Iododeboronation with and without Gold Catalysis: Application to Radiolabelling of Arenes

Webster, S., O'Rourke, K. M., Fletcher, C., Pimlott, S. L., Sutherland, A. & Lee, A-L., 19 Jan 2018, In : Chemistry - A European Journal. 24, 4, p. 937-943 7 p.

Research output: Contribution to journalArticle

Open Access
Norepinephrine Plasma Membrane Transport Proteins
Single photon emission computed tomography

Auto-Tandem Catalysis: PdII-Catalysed Dehydrogenation/Oxidative Heck Reaction of Cyclopentane-1,3-diones

Lamb, C. J. C., Nderitu, B. G., McMurdo, G., Tobin, J. M., Vilela, F. & Lee, A-L., 22 Dec 2017, In : Chemistry - A European Journal. 23, 72, p. 18282–18288 7 p.

Research output: Contribution to journalArticle

Open Access

Activities 2013 2013

  • 1 Membership of peer review panel
  • 1 Other

Engineering and Physical Sciences Research Council (External organisation)

Lee, A. (Member)
17 Oct 2013

Activity: MembershipMembership of peer review panel