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Personal profile

Research interests

We are a catalysis and synthesis group with particular interest in the following areas:

1. Gold Catalysis
In the past decade, gold has emerged as a powerful catalyst for the electrophilic activation of carbon-carbon p bonds. Gold catalysis represents a new frontier in catalysis with scope for further discoveries and development, particularly in the field of asymmetric gold catalysis. We are interested in the development of novel gold catalysed reactions with the aim of expanding the current toolkit of synthetic techniques. Recent highlights from our group include developing novel gold-catalysed reactions with cyclopropenes and allenes.

For representative publications, see: Org. Lett., 2012, 14, 898. Abstract; Chem. Commun.,2011, 47, 1333 - 1335. Abstract; Org. Biomol. Chem., 2010, 8, 4090 - 4095. Abstract; Org. Lett.2010, 12, 484-487. Abstract; Chem. Commun., 2008, 6405-6407. Abstract

2. Palladium Catalysis
We have recently developed a mild and ligand free cationic Pd(II) system for conjugate additions to hindered ?-substituted cyclohexenones. Current work in the group centres around the development and futher applications of the cationic Pd(II) system.

For representative publications: Org. Lett., 2012, ASAP, DOI:10.1021/ol300794a. Abstract

3. N-Heterocyclic Carbene (NHC) - Type Ligands for Catalysis
The chemistry of N-heterocyclic carbenes (NHCs) and in particular their application as ligands, has developed rapidly since the synthesis of the first isolable species in 1991. NHC ligands are active in various transition metal catalysed reactions as well as in organocatalytic reactions. This area holds great promise in terms of the design of novel and modular ligands with different stereochemical topography.

For representative publication, see: Chem. Commun., 2011, 47, 328 - 330. Abstract and review: Aust. J. Chem. 2011, 64, 1118–1132. Abstract

4. Chiral rotaxanes
One of the most interesting and yet least exploited features of rotaxanes is chirality - a rotaxane consisting of an asymmetric rotor and asymmetric axis can have cyclochirality, even if both the rotor and axis are themselves achiral. To date, there are no efficient methods for the catalytic enantioselective synthesis of cyclochiral rotaxanes. We are interested in tackling this challenging problem using tools from the field of asymmetric catalysis.

Research Group Contact Details

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  • 3 Similar Profiles
Gold Chemical Compounds
Catalysis Chemical Compounds
Alkenes Chemical Compounds
Catalysts Chemical Compounds
Ethers Chemical Compounds

Research Output 2008 2019

Silver Effect in Regiodivergent Gold-Catalyzed Hydroaminations

Veguillas, M., Rosair, G. M., Bebbington, M. W. P. & Lee, A-L., 14 Feb 2019, In : ACS Catalysis. 9, 3, p. 2552-2557 6 p.

Research output: Contribution to journalArticle

Open Access
File
Silver
Gold
Regioselectivity
Alkynes
Substrates

Dual copper- and photoredox-catalysed reactions

McLean, E. B. & Lee, A-L., 20 Sep 2018, In : Tetrahedron. 74, 38, p. 4881-4902 22 p.

Research output: Contribution to journalReview article

Catalysis
Copper
Transition metals

Gold(I)-Catalysed Hydroarylation of 1,3-Disubstituted Allenes with Efficient Axial-to-Point Chirality Transfer

Sutherland, D. R., Kinsman, L., Angiolini, S. M., Rosair, G. M. & Lee, A-L., 11 May 2018, In : Chemistry - A European Journal. 24, 27, p. 7002-7009 8 p.

Research output: Contribution to journalArticle

Chirality
Gold
Stereoselectivity
propadiene

Metal-, Photocatalyst-, and Light-Free, Late-Stage C–H Alkylation of Heteroarenes and 1,4-Quinones Using Carboxylic Acids

Sutherland, D. R., Veguillas, M., Oates, C. L. & Lee, A., 2 Nov 2018, In : Organic Letters. 20, 21, p. 6863-6867 5 p.

Research output: Contribution to journalArticle

Light Metals
Quinones
Alkylation
Photocatalysts
Carboxylic Acids

Rapid Iododeboronation with and without Gold Catalysis: Application to Radiolabelling of Arenes

Webster, S., O'Rourke, K. M., Fletcher, C., Pimlott, S. L., Sutherland, A. & Lee, A-L., 19 Jan 2018, In : Chemistry - A European Journal. 24, 4, p. 937-943 7 p.

Research output: Contribution to journalArticle

Open Access
File
Radiopharmaceuticals
Gold
Catalysis
Norepinephrine Plasma Membrane Transport Proteins
Single photon emission computed tomography

Activities 2007 2018

University of York - Seminar

Lee, A. (Speaker)
17 May 2017

Activity: Talk or presentationInvited talk

23rd RSC Lakeland Symposium on Heterocyclic Chemistry, Grasmere

Lee, A. (Speaker)
4 May 20178 May 2017

Activity: Talk or presentationOral presentation

EPSRC UK National Mass Spectrometry Facility 30th Anniversary Symposium

Lee, A. (Speaker)
10 Jul 2017

Activity: Talk or presentationInvited talk

University of Lancaster - Seminar

Lee, A. (Speaker)
27 Sep 2017

Activity: Talk or presentationInvited talk